1,720,982 research outputs found
Budd-Chiari syndrome in chronic myeloid leukemia.
A29-year-old Ph-positive patient in accelerated
phase chronic myeloid leukemia (CML) with
marked thrombocytosis developed fever,
abdominal pain and signs of severe acute hepatitis,
although was negative for viral markers. Real-time
and Doppler ultrasound (US) scan showed marked
hepatomegaly, caudate lobe hypertrophy (Figure 1),
failure to visualize hepatic veins and their flow, portal
vein ectasy with slow hepatopetal flow, splenomegaly
and massive ascites. MRI and angiography
confirmed occlusion of all hepatic veins and partial
obstruction of the inferior vena cava hepatic segment,
likely due to disproportionate caudate lobe
enlargement. These findings suggested Budd-Chiari
syndrome (BCS); treatment was diuretics, anticoagulants,
chemotherapy and peritoneum-jugular
shunt. Liver histology, obtained by uncomplicated
percutaneous biopsy, confirmed the diagnosis (Figure
2
Endogastric capsule (EC) for molecular analysis of helicobacter pylori (HP) infection and gastric pH
Clinical relevance of intrahepatic hepatitis B virus DNA in HBsAg-negative HBcAb-positive patients undergoing hematopoietic stem cell transplantation for hematological malignancies.
Endogastric capsule (EC) for determining E-cadherin gene (CDH-1) promoter hypermethylation in DNA isolated from gastric juice
Ultrasound-guided fine needle cutting biopsy for the characterization of diffuse liver diseases in bone marrow transplant patients.
Liver disease is a frequent complication in bone marrow transplant recipients and may occur early or late in the post-transplant period. Using ultrasound-guided fine needle (1.2 mm, 18 G) cutting biopsy, we studied six patients with undefined late post-BMT liver disease. No procedure-related complications occurred and all liver biopsies were informative, leading to changes in therapeutic approach. In our small series, the most frequent cause of hepatic damage was drug toxicity. US-guided fine needle cutting biopsy is a useful and easy tool for the work-up of unexplained post-BMT liver disease
CHRONIC LIVER DISEASE AND ACTIVE HEPATITIS C VIRUS INFECTION IN PATIENTS WITH ANTIBODIES TO THIS VIRUS
Liver nodular regenerative hyperplasia after bone marrow transplant.
We report an unusual liver disease which may occur after bone marrow transplantation, i.e. the collapse of hepatic lobuli followed by regenerative islets: the resulting clinical picture may mimic GvHD or a viral disease, but histology is diagnostic, showing nodular regeneration in the absence of inflammation or fibrosis
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