1,720,974 research outputs found
Modificazioni del metabolismo degli esteri del colesterolo nell’ageing: effetti benefici della restrizione calorica.
No full textAlterations of lipid and cholesterol metabolism in cachetic tumor-bearing rats are prevented by insulin
No full textFACTORS ASSOCIATED WITH A RAPID NORMALIZATION OF HBA1C IN NEWLY DIAGNOSED TYPE 2 DIABETES PATIENTS SEEN IN A SPECIALIST SETTING.
No full textThe time to achieve good metabolic control after diagnosis is essential for type 2 diabetes patients because it can influence long-term prognosis. This study aimed to elucidate the predictive role of several clinical and organization factors in normalizing metabolism within 6 months. A multi-centered, retrospective, observational study on 960 patients, with diabetes duration of 12 months or less, consecutively seen in 123 Italian clinics, was undertaken. Information about clinic's organization, along with data abstracted from medical records at enrollment (first visit) and after 6 months (follow-up visit), was collected. At 6 months, HbA1c dropped by -3.1 ± 2.2 points in those who achieved HbA1c <7 % (responders), whereas in non-responders (HbA1c ≥7 %), the mean reduction was -1.8 ± 1.9. The intervention markedly reduced lipids, blood pressure, BMI, and waist circumference, especially in responders. The presence of a diabetes team correlated with a likelihood of HbA1c normalization (OR 1.94, 1.17-3.22). By contrast, indicators of advanced disease such as previous retinopathy (0.53, 0.29-0.98), use of secretagogues (0.40, 0.25-0.64), high levels of HbA1c at first visit and related insulin use emerged as adverse factors. Early detection of diabetes, along with human resources and organization, was found to play a crucial role in rapidly attaining good metabolic control
Possibile coinvolgimento della Pgp MDR1 nel controllo della proliferazione in una linea di cellule linfoblastiche umane
No full textIl trattamento insulinico modifica l'espressione dei geni correlati col metabolismo lipidico in linfomonociti provenienti da pazienti con grave carenza insulinica
No full textCholesterol esters as growth regulators of lymphocytic leukaemia cells
No full textOBJECTIVE: Alterations in plasma lipid profile and in intracellular cholesterol homoeostasis have been described in various malignancies; however, significance of these alterations, if any, in cancer biology is not clear. The aim of the present study was to investigate a possible correlation between alterations in cholesterol metabolism and expansion of leukaemia cell numbers.
MATERIALS AND METHODS: Lipid profiles in plasma and in primary leukaemia cells isolated from patients with acute or chronic lymphocytic leukaemia (ALL and CLL) were studied.
RESULTS AND CONCLUSIONS: Decreased levels of HDL-C were observed in plasma of leukaemic patients, levels of total cholesterol, LDL-C, triglycerides and phospholipids were unchanged or only slightly increased. As compared to normal lymphocytes, freshly isolated leukaemic cells showed increased levels of cholesterol esters and reduction in free cholesterol. Growth stimulation of ALL and CLL cells with phytohemagglutinin led to further increase in levels of cholesterol esters. Conversely, treatment with an inhibitor of cell proliferation such as the mTOR inhibitor, RAD, caused decline in population growth rate of leukaemia cells, which was preceded by sharp reduction in rate of cholesterol esterification. On the other hand, exposure of leukaemic cells to two inhibitors of cholesterol esterification, progesterone and SaH 58-035, caused 60% reduction in their proliferation rate. In addition to demonstrating tight correlation between cell number expansion and cholesterol esterification in leukaemic cells, these results suggest that pathways that control cholesterol esterification might represent a promising targets for novel anticancer strategies
“THE SARDINIAN NEWBORN-IDDM (SNI) STUDY”. PREVALENZA DI AUTOANTICORPI ANTI-ISOLA PANCREATICA (ICA), ANTI GAD (GADA) E ANTI IA2 (IA-2A) IN UNA POPOLAZIONE DI BAMBINI ALLA NASCITA, AL PRIMO E AL SECONDO ANNO DI FOLLOW UP
No full textPossibile ruolo della P-gp nella riduzione del colesterolo di membrana e nella trasduzione del segnale durante durante la proliferazione
No full textDietary restriction counteracts age-related changes in cholesterol metabolism in the rat
No full textThe effects of ageing on the metabolism of cholesterol were examined in three
different organs (liver, aorta and brain) of 6-, 12- and 24-month-old male
Sprague-Dawley rats. Ageing was associated with a significant increase in
intracellular cholesterol esters in all three organs. Steady state mRNA levels of
multidrug resistance protein (MDR) and acylCoA:cholesterol acyl transferase
(ACAT), enzymes involved in cholesterol import and esterification, were also
increased. By contrast, expression of mRNA for neutral cholesterol ester
hydrolase (nCEH) and caveolin-1, proteins involved in cholesterol ester
hydrolysis and export, were significantly reduced. Dietary restriction is the
only intervention shown to extend lifespan and retard age-related declines in
function in mammals. To further explore the possible correlation between changes
in cholesterol esterification and ageing, we analysed cholesterol metabolism in
liver, aorta, and brain of aged rats exposed to two dietary restriction regimens:
intermittent (alternate-day) fasting (IF) and food intake restriction (60% of ad
libitum feeding). Both dietary regimens attenuated the age-related changes in
cholesterol esters and in the expression of genes involved in cholesterol
metabolism. These results provide evidence that distinctive age-associated
changes in intracellular cholesterol metabolism occur in rats. Furthermore, these
modifications can be partially reversed by dietary restriction, a condition known
to affect the ageing process. Age-related changes in cholesterol metabolism may
play a role in triggering and/or aggravating senescence-related disorders
characterized by altered cholesterol homeostasis
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