16,935 research outputs found
Tissue and Salivary NMR Metabolomics in Reticular-Type Oral Lichen Planus
No full textOral lichen planus (OLP) is a chronic T-cell-mediated autoimmune disease, with low potential for malignant transformation. Its etiology remains unclear, necessitating immunohistochemical and molecular-level studies to enhance diagnosis and management. Thirteen patients diagnosed with OLP and 13 healthy controls (HCs) were enrolled from three centers. Mucosal tissue samples collected during diagnostic biopsies and unstimulated whole saliva samples were analysed. A comprehensive approach was taken, with high-resolution magic angle spinning (HR-MAS) 1H-NMR spectroscopy performed on biopsies and liquid 1H-NMR spectroscopy on saliva samples to identify potential biomarkers correlated with OLP. Multivariate analyses effectively distinguish OLP patients from HC based on metabolic profiles, with key metabolites contributing to the separation. In tissue, triglycerides were significantly elevated in OLP biopsies, whereas amino acids such as glutamate, glutamine, taurine, glycine and alanine were significantly decreased in OLP tissues compared with controls (p < 0.05). Salivary analysis revealed significant alterations in compounds of bacterial origin-such as isobutyrate, isocaproate, isovalerate and agmatine-suggesting dysbiosis in OLP patients. The metabolic alterations identified highlight the roles of oxidative stress and lipid metabolism in OLP pathogenesis and suggest potential biomarkers for OLP diagnosis. These findings provide new insights into the molecular mechanisms of OLP, which may have important clinical implications for future diagnostic and therapeutic strategies
STUDY OF THE EFFECTS OF SHORT-CHAIN PFASs ON HUMAN CELLS WITH NMR-METABOLOMICS
No full textApplication of NMR-based Metabolomics to study the effects of shortchain PFASs on an in vitro mode
An Article About Albertus C. Van Raalte, Author Unknown, Except for Parts Taken from an Article by Anna C. Post
No full textAn article about Albertus C. Van Raalte, author unknown, except for parts taken from an article by Anna C. Post. The author knew first generation persons in the Holland settlement and therefore, the article has some value.https://digitalcommons.hope.edu/vrp_1890s/1012/thumbnail.jp
Dissociative Dimensions and Their Implications for Emotional Dysregulation Underlying Borderline Personality Disorder Features
No full textEmotion dysregulation is considered a core feature of borderline personality disorder (BPD). The role of dissociation in BPD has been discussed from different perspectives. Nevertheless, implications of dissociation for BPD features are not clear. The current study estimated mediation effects of dissociative dimensions on the relationships between several emotion regulation strategies (ERSs) and BPD features among 281 adults recruited from the general population. The online survey administered a comprehensive self-report battery for the assessment of maladaptive and adaptive ERSs together with dissociative dimensions. Borderline personality disorder features were also self-report screened. Results showed significant indirect effects of dissociation on the relationships between ERSs and BPD features. Dissociation was a full mediator of the relationship between deficits with problem-solving skills and BPD criteria. The study confirmed that emotion dysregulation is a core feature of BPD and that the dissociative dimensions should be included as relevant maladaptive mechanisms sustaining BPD emotional difficulties
Cross-amplification in falcons and their hybrids: A new im- plemented multi-locus panel for conservation and forensic purposes
No full textFalcons and their hybrids are among the most traded raptor species, with a significant proportion of international market involving countries with a strong falconry tradition. The trend in legal trade of falcons is strongly increased likewise the illegal international market is expected to swell due to the growing interest in wild-caught rather than captive-bred individuals. Biomolecular investigations represent a practical tool to foster actions finalized in tracking any wildlife trade, so contributing to the prevention of species overexploitation too. Contextually, they can inform about wild populations allowing the monitoring of genetic variability and structure. Microsatellites loci (STR) are amongst the most popular markers in molecular ecology. Despite the availability of species-specific microsatellite loci in some Falco species, a newly defined panel permitting the genetic analysis across the mostly traded Falco spp. and their hybrids has not been validated yet. Here we report the characterization of a panel of 21 highly polymorphic microsatellite loci selected from literature and evaluate its reliability for conservation and forensic purposes. We included in the study 163 captive-bred individuals belonging to in six species of falcons (Falco biarmicus, Falco cherrug, Falco pelegrinoides, Falco peregrinus, Falco rusticolus and Falco tinnunculus) and three hybrids (Falco cherrug x Falco peregrinus, Falco peregrinus x Falco rusticolus and Falco cherrug x Falco rusticolus). We identified two sample sets, including individuals from pure species belonging to 46 parental groups tested for genetic variability and differentiation and parentage analysis, and another enclosing individuals from pure species F. cherrug, F. peregrinus, F. rusticolus and their F1 hybrid individuals tested in the analysis of hybrid detection.
The proposed STR panel could be of value in monitoring genetic diversity and differentiation in wild populations and describing mating systems and gene flow; moreover, it has the potential to perform individual identification and parentage analysis, so contributing to investigate parental claims, illegal transfer or suspected smuggling in Falco species and their hybrids
Richardson, Barbauld, and the construction of an early modern fan club
No full textMPhilMuch has been written about the life and long works of the eighteenth century epistolary novelist, Samuel Richardson, but the prospect of his position as the first celebrity novelist – responsible for courting his own fame as well as initiating his own fan club – has largely been ignored. The body of manuscripts housed at the National Art Library in the Victoria and Albert Museum in London provides the modern scholar with evidence of the skeletal beginnings of an early fan club. This thesis aims to show how these manuscripts were turned into a saleable commodity by the publisher and entrepreneur Richard Phillips, while under the guiding hand of another, slightly later, literary celebrity, Anna Laetitia Barbauld. In order to restore Richardson’s reputation amongst a new nineteenth century audience, Barbauld was required to construct her own idea of him as an eighteenth century celebrity author, and in doing so the insecurities of a self-professed, apparently diffident man, are revealed. Barbauld’s capacious, but heavily edited selection of letters is analyzed in this thesis, providing ample evidence that Richardson’s correspondents were more than just eager letter writers. By using Barbauld’s biography of Richardson this thesis aims to show how she manipulates the genre of life writing in her construction of him.
This thesis offers an alternative reading of how the Richardson manuscripts are viewed, redefining them as not simply a collection of letters, but as a collective entity, deliberately selected and archived as evidence of an early modern fan club, and its celebrity managing director
Selection of work by Anna Gerber
No full textVarious journals and magazines Anna Gerber has contributed to. Anna Gerber is a graphic designer and writer based in London.
She is the author and designer of All Messed Up: Unpredictable Graphics (Laurence King, 2004) and co-editor and co-designer
of Influences: A Lexicon of Contemporary Graphic Design (Die Gestalten Verlag, 2006) with Anja Lutz. She writes regularily for magazines such as Print, Eye, Creative Review, Varoom and Idea Magazine and her work has also been published in shift!, dot dot dot and +rosebud.
She teaches at the London College of Communication on the BA Graphic Design and MA Design Writing Criticism programmes. She has also held workshops and lectures across the U.K. (including Tate Modern and the V&A Museum), as well as in India, the U.S., Australia and Malaysia.
Anna Gerber is currently engaged in research and developing projects relating to sustainability and how it applies to graphic
design as well as exploring contemporary graphic design in India
Dissociative Dimensions and Their Implications for Emotional Dysregulation Underlying Borderline Personality Disorder Features
No full textEmotion dysregulation is considered a core feature of borderline personality disorder (BPD). The role of dissociation in BPD has been discussed from different perspectives. Nevertheless, implications of dissociation for BPD features are not clear. The current study estimated mediation effects of dissociative dimensions on the relationships between several emotion regulation strategies (ERSs) and BPD features among 281 adults recruited from the general population. The online survey administered a comprehensive self-report battery for the assessment of maladaptive and adaptive ERSs together with dissociative dimensions. Borderline personality disorder features were also self-report screened. Results showed significant indirect effects of dissociation on the relationships between ERSs and BPD features. Dissociation was a full mediator of the relationship between deficits with problem-solving skills and BPD criteria. The study confirmed that emotion dysregulation is a core feature of BPD and that the dissociative dimensions should be included as relevant maladaptive mechanisms sustaining BPD emotional difficulties
Author and Lecturer Anna Bird Stewart will Speak at the University of Dayton
No full textNews release announcing the visitation and speech of author and lecturer Anna Bird Stewart to the University of Dayton
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