1,721,406 research outputs found
Investigational drugs for ischemic stroke: what’s in the clinical development pipeline for acute phase and prevention?
No full textIntroduction: Stroke is a leading cause of disability and mortality and its burden expected to increase. The only approved drug for acute ischemic stroke (IS) is the intravenous thrombolytic alteplase. The risk of bleeding complications is one of the reasons for the undertreatment of eligible patients. Numerous drugs are currently being developed to improve safety-efficacy. Areas covered: We reviewed literature from 1 January 2000, to 15 January 2022 for the development and testing of novel drugs with the aim of targeting treatment at prevention of ischemic stroke: PubMed, MEDLINE, Google Scholar, and ClinicalTrial.gov. Expert opinion: The pathophysiology of IS involves multiple pathways causing cerebral artery obstruction and brain tissue ischemia. Data suggest that tenecteplase is a promising fibrinolytic agent with a superior efficacy-safety profile, compared to alteplase. Current guidelines consider a short-term cycle of mannitol or hypertonic saline to be advisable in patients with space-occupying hemispheric infarction. Regarding primary and secondary prevention, research is primarily focused on identifying mechanisms to improve the safety-efficacy profile using a ‘hemostasis-sparing’ approach. Further evaluation on those agents that have shown promise for their risk/benefit profiles, would benefit greatly a neurologist’s capacity to successfully prevent and treat IS patients
Epithelioid sarcoma of the thumb presenting as a periungual warty lesion: Case report and revision of the literature
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Neutron physics of the Re/Os clock. I. Measurement of the (n, gamma) cross sections of 186,187,188Os at the CERN n_TOF facility
No full textThe precise determination of the neutron capture cross sections of 186Os and 187Os is important to define the s-process abundance of 187Os at the formation of the solar system. This quantity can be used to evaluate the radiogenic component of the abundance of 187Os due to the decay of the unstable 187Re (t1/2=41.2 Gyr) and from this to infer the time duration of the nucleosynthesis in our galaxy (Re/Os cosmochronometer). The neutron capture cross sections of 186Os, 187Os, and 188Os have been measured at the CERN n_TOF facility from 1 eV to 1 MeV, covering the entire energy range of astrophysical interest.© 2010 The American Physical Societ
PRGF in the cartilage defects in the knee joint
No full textIn the last few years the improvements of biotechnology allowed the development of new techniques for the stimulation and the acceleration of tissue healing and bone regeneration, particularly of platelet-rich therapies. The progressive knowledge of the tissuetal phases after a traumatic injury showed the role of a range of growth factors and cytokines, secreted by serum and degranulating platelets, in the repair process. Every growth factor such as PDGF, TGF-beta, IGF-1 and VEGF has a specific function, but for the healing of the tissue the release of the pool of these growth factors is important. The platelets may be considered like a reservoir of growth factors; among the platelet-rich preparations, the importance of platelet release growth factor (PRGF) was given by their versatility. The effect of these preparations is not only mytogenic, but also an angiogenic effect, antibacterial and anti-inflammatory. In clinical fields, PRGF, often associated to some biomaterials, can be used for the treatment of chronic ulcers and for bone and soft tissue regeneration. Particularly in orthopaedic field, PRGF accelerate healing process and avoid further degeneration of the bone, the cartilage, the tendons and the ligaments. For example, platelet-rich preparations can be used during a tendon suture or a ligament reconstruction (ACL) or, finally, for the treatment of tissue avascular like the cartilage with the purpose of an acceleration in functional recovery. The arthroscopic repair of chondral lacerations or meniscus tears represents the future step of these versatile preparations. Symptomatic cartilage defects in the knee joint have aroused attention and clinical interest in recent years because these lesions can be difficult to treat. Despite the fact that, biological surgery of the past had poor consistent results, now there is a new interest for these techniques, particularly for platelet-related-growth-factors (PRGF). The recent improvement of tissue engineering and the biological innovation of biomechanical properties of the materials used (matrix scaffolds, cartilage grafts, growth factors and genetic engineering) have increased the research in the cartilage resurfacing and hyaline tissue regeneration
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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