1,721,083 research outputs found
A Teacher Friendly Environment to Foster Learner-centered Customization in the Development of Interactive Educational Packages
No full textA good teacher is able to customize the lesson to fit the requirements and needs of the learners he or she has in the classroom. This process becomes difficult and expensive in open and distance education, where customization means availability of similar contents, presented in diversified styles.Amethodology and the tools to tackle the problem by using automated course compilation have been developed in the 3DE project (Design, Development, and Delivery Electronic Environment for Educational Multimedia). The work on course customization showed the key role of the authoring process and the related problems. This paper summarizes the methodology and describes the development environment designed to assist authors in the creation of customized educational material. The environment seeks to help teachers/authors understand the relations among pedagogical and technical aspects and provides instructions, guidelines, and assistance for the development of learning-styles-aware material. The paper focuses on the author interface of the environment with details on the pedagogical framework, the authors' guide, the classification guide, and the metadata tool
The human haptoglobin gene: transcriptional regulation during development and acute phase induction
No full textHaptoglobin is a plasma protein scarcely present in fetal but abundant in adult serum, where it is present at a concentration of approximately 150 mg/100 ml. In this paper we show by run-on experiments that the haptoglobin (Hp) gene is actively transcribed in adult but not in fetal liver nuclei. Studies with established cell lines indicate that the Hp gene is expressed in the hepatoma cells HepG2 but not in the hepatoma cell line Hep3B nor in HeLa cells. Plasmids carrying various segments of the 5' flanking region of the Hp gene fused to the chloramphenicol acetyl transferase (CAT) gene direct CAT transcription when introduced into HepG2 but are inactive in Hep3B and in HeLa cells, thus behaving like the resident chromosomal Hp gene. Deletion analysis defines a region, upstream to the transcription initiation site, essential for cell-specific expression. The Hp gene is induced in Hep3B cells by treatment with supernatant from LPS-stimulated monocytes (SMS), in a manner mimicking the acute phase reaction. We characterize the DNA segment necessary and sufficient for cell-specific expression of the Hp-CAT constructions in HepG2 and show that the same segment is also sufficient for acute phase induction in Hep3B
The human haptoglobin gene: transcriptional regulation during development and acute phase induction.
No full textThe human haptoglobin gene: transcriptional regulation during development and acute phase induction.
No full textPost-transcriptional control of negative acute phase genes by transforming growth factor beta.
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Post-transcriptional control of negative acute phase genes by transforming growth factor beta
No full textDuring the acute phase (AP) reaction the expression of a series of liver-specific genes coding for secretory proteins is either stimulated or suppressed by different cytokines released by activated monocytes. Transforming growth factor beta (TGF-beta) is a cytokine that, first identified for its ability to regulate cellular growth, has been gradually recognized to modulate several other functions. We have investigated the effect of TGF-beta on the expression of acute phase genes in liver cells. We found that TGF-beta selectively induces a specific decreases in the amount of mRNAs of genes negatively regulated during AP reaction, like albumin and apolipoprotein A-I (ApoA-I). The inhibitory effect of TGF-beta on the expression of negative AP genes is primarily post-transcriptional and it is very likely to be mediated via an enhancement of the turnover of both albumin and ApoA-I mRNAs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Croce e il clima della storia. Una risposta a Dipesh Chakrabarty
No full textThe paper deals with a thesis by Dipesh Chakrabarty on the climate of history. In this thesis, Chakrabarty discusses Vico, Croce, and historicism, arguing that the historicist view is incompatible with the interpretation of history that emerges in the current debate on the Anthropocene. The paper, which is a response to Chakrabarty’s arguments, attempts to provide a more comprehensive and complex view of historicism and Croce’s philosophy. In particular, it shows that Croce’s concepts of history and nature can correspond to some cases of contemporary philosophical and historical debate
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