3,716 research outputs found
Effect of A1 adenosine receptor overexpression on cardiac sarcoplasmic reticulum calcium pump
No full textCardioprotective effect of A1 adenosine receptor overexpression is associated with reduced sarcoplasmic reticulum calcium uptake
No full textOn the influence of river Basin morphology and climate on hydrogeomorphic floodplain delineations
No full textElevation-based hydrogeomorphic models are widely used to parsimoniously delineate floodplains with limited input data using topographic gradients to distinguish floodplain areas from hillslopes. Hydrogeomorphic models generally use scaling laws to assess flood flow depths as a function of contributing drainage areas. Floodplains are consequently mapped as those areas underlying maximum flood levels. Recent scientific literature has demonstrated that hydrogeomorphic models consistently perform from regional to global scale, validating geomorphic floodplain delineations in diverse morphological and hydroclimatic river settings. Nevertheless, the relationship between model fidelity, basin morphology, and basin hydroclimatic conditions is still unclear. Specifically, further investigations on the applicability of scaling laws in semi-arid and low-gradient basins is needed. In this work we investigated how climatic variability and basin slope can influence the parameterization of the abovementioned scaling laws in support of hydrogeomorphic floodplain modeling. Eleven basins in the west-central United States were selected as case studies. This research demonstrated that sub-basins slope and annual rainfall are the most influential morphometric and climatic parameters on scaling law regressions. Specifically, we found that scaling relationships are inconsistent in defining semi-arid basin floodplains (average annual rainfall lower than 570 mm) with low-gradient valley slopes (lower than 5%)
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by MC-RR
No full textAs cynobacterial blooms frequently occur in fresh waters throughout the world, microcystins (MCs) have caused serious damage to both wildlife and human health. MCs are known to have developmental toxicity, however, the possible molecular mechanism is largely unknown. This is the first toxicological study to integrate post-transcriptomic, proteomic and bioinformatics analysis to explore molecular mechanisms for developmental toxicity of MCs in zebrafish. After being microinjected directly into embryos, MC-RR dose-dependently decreased survival rates and increased malformation rates of embryos, causing various embryo abnormalities including loss of vascular integrity and hemorrhage. Expressions of 31 microRNAs (miRNAs) and 78 proteins were significantly affected at 72 hours post-fertilisation (hpf). Expressions of miR-430 and miR-125 families were also significantly changed. The altered expressions of miR-31 and miR-126 were likely responsible for the loss of vascular integrity. MC-RR significantly reduced the expressions of a number of proteins involved in energy metabolism, cell division, protein synthesis, cytoskeleton maintenance, response to stress and DNA replication. Bioinformatics analysis shows that several aberrantly expressed miRNAs and proteins (involved in various molecular pathways) were predicted to be potential MC-responsive miRNA-target pairs, and that their aberrant expressions should be the possible molecular mechanisms for the various developmental defects caused by MC-RR
The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR
No full textMicrocystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress.Microcystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress
So Tom has turned a poet, what a dear [first line]
No full textstrophicnasame as Box 192 Item 50Cover is duplicated in 192.050.
Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnasame as Box 192 Item 50Cover is duplicated in 192.050.
Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
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