1,721,457 research outputs found
Rethinking to riluzole mechanism of action: the molecular link among protein kinase CK1δ activity, TDP-43 phosphorylation, and amyotrophic lateral sclerosis pharmacological treatment
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
L’inefficienza dell’utilizzo delle risorse pubbliche come limite all’insindacabilità delle scelte discrezionali della pubblica amministrazione: coordinate introduttive
No full textIl contributo appare articolato in due nuclei. Il primo ricostruisce criticamente l’incidenza dei mutamenti della concezione di pubblica amministrazione e della natura della responsabilità amministrativa sul sindacato della Corte dei conti in ordine all’osservanza delle norme di condotta ed, in specie, di quelle da cui derivano gli obblighi di efficacia, efficienza ed economicità. Il secondo, invece, contiene alcune riflessioni in ordine alla specificazione del contenuto dei predetti obblighi: non tipizzato dalle norme di legge, ma riservato alla discrezionalità della pubblica amministrazione sindacabile dalla Corte dei conti nei limiti della ragionevolezza e logicità concretizzate sulla base degli standard ricavati dalle scienze dell’amministrazione il cui apporto appare essenziale per la costruzione di una pubblica amministrazione al servizio del cittadino
Protein–Ligand Docking: Virtual Screening and Applications to Drug Discovery
No full text---The term virtual screening (VS) was rst reported in literature in 1997 (Horvath 1997), and refers to computational techniques aimed at streamlining the drug discovery process through in silico identication of novel hits from large chemical libraries. In the early 1990s, the drug discovery paradigm was overturned by the introduction of high-throughput screening (HTS) (Bleicher et al. 2003) and combinatorial chemistry (Geysen et al. 2003). These techniques promised to accelerate the drug discovery process by enabling the synthesis of large libraries of chemical compounds and the assay of their biological activity against several targets in a short period of time. However, the revolutionary approach soon proved to be expensive and not productive as expected, as many of the identied hits failed the lead optimization stage due to unsuitable pharmacokinetic properties. The development of alternative strategies to select appropriate compounds, while removing unsuitable structures, aimed at si..
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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