2,709 research outputs found

    The Classics of the First Lorenzo de' Medici. For a New Critical Reading of Corinth

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    openIl presente lavoro si propone di rileggere una delle prime opere di Lorenzo de’ Medici, "Corinto", attraverso temi letterari che lo caratterizzano, tenendo presente i modelli latini, greci e italiani ai quali l’autore attinge e confrontandone altri, pertinenti ai temi analizzati. Dopo una rapida introduzione sul contesto storico in cui il poemetto si inserisce, esso viene presentato per quanto concerne il contenuto e la storia redazionale, approfondita nell’Appendice, dove si presentano inoltre i testi di riferimento. Segue dunque la nuova lettura critica. La riflessione sul concetto di classico e su Lorenzo quale autore e personaggio del poemetto conclude l’analisi.The present work aims to re-read one of Lorenzo de’ Medici’s first works, "Corinto", through the literary themes which characterize it, keeping in mind the Latin, Greek and Italian models on which the author draws and comparing others, pertinent to the themes analyzed. After a quick introduction to the historical context in which the poem fits, it is presented in terms of content and editorial history, detailed in the Appendix, where the reference texts are also presented. Thus follows the new critical reading. The reflection on the concept of classic and on Lorenzo as author and character of the poem concludes the analysis

    Articolo 6 - Autorità per la vigilanza sui contratti pubblici di lavori, servizi e forniture

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    commento all'art. 6 del codice dei contratti (in materia di AVCP

    Articolo 8 - Disposizioni in materia di organizzazione e di personale dell’Autorità e norme finanziarie

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    Commento all'art. 8 del Codice dei contratti pubblici (in tema di organizzazione e personale AVCP

    Articolo 8 - Disposizioni in materia di organizzazione e di personale dell’Autorità e norme finanziarie

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    Commento all'art. 8 del Codice dei contratti pubblici (in tema di organizzazione e personale AVCP

    Influence of Circulating Endothelin-1 and Asymmetric Dimethylarginine on Whole Brain Circulation Time in Multiple Sclerosis

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    Blood-brain barrier (BBB) breakdown, inflammatory and immune cell activation, and chronic cerebral hypoperfusion are features of multiple sclerosis (MS). The aim is to determine the influence of endothelin-1 (ET1) and asymmetric dimethylarginine (ADMA) on cerebral circulation time (CCT) in patients with MS. In all, 64 patients with MS (39 relapsing-remitting [RR]-MS; 25 secondary progressive [SP]-MS subtype) and 37 controls (C) were studied. Cerebral circulation time was obtained by angiography. Plasmatic ET1 and ADMA were measured by enzyme-linked immunosorbent assay. Lesion load (LL) and brain volume (BV) were obtained by magnetic resonance imaging. Cerebral circulation time was correlated to ET1, ADMA, LL, BV, disease duration (DD), and Expanded Disability Status Scale (EDSS). In MS, both ET1 and ADMA were significantly higher than C (P < .0001); CCT was approximately 2 times lower than C (P < .0001) and significantly slower in SP than in RR-MS (P = .0215). Cerebral circulation time significantly correlated with ET1 in SP-MS (r = 0.38), whereas in RR-MS CCT significantly correlated with DD (r = 0.75). The LL, BV, and EDSS did not correlate with CCT. Endothelin-1 significantly influences CCT delay in SP-MS. Diversely, CCT in RR-MS is independent of ET1 and correlates significantly with DD. We conclude that in RR-MS, DD responds to neurovascular damage accumulation. It is supposed that high ET1 and ADMA levels stem from a protective response to early insults, aimed at opposing nitric oxide overproduction, whereas persistent pathological ET1 and ADMA levels translate into detrimental long-term effects, due to increased brain micro-vessel resistance

    First person – Alba Delrio-Lorenzo

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    First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Alba Delrio-Lorenzo is first author on ‘Sarcoplasmic reticulum Ca2+ decreases with age and correlates with the decline in muscle function in Drosophila’, published in JCS. Alba is a PhD student in the lab of Javier García-Sancho and María Teresa Alonso at the Instituto de Biología y Genética Molecular (IBGM), University of Valladolid, Spain, investigating the molecular mechanisms implicated in aging, particularly muscle aging.Peer reviewe

    [Letter from Lorenzo de Zavala to Antonio Lopez de Santa Anna, March 11, 1828]

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    Lorenzo de Zavala to Antonio Lopez de Santa Anna: On political tensions surrounding the recent revolt by Guerrero and the position taken by the author. (Tlalpan), March 11, 1828
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