2,381 research outputs found
La complessità dell’esperienza depressiva nell’anziano: diagnosi e terapia, una chimera?
No full textNel contesto generale delle peculiarità del paziente geriatrico si sono delineati i possibili elementi distintivi del disturbo depressivo dell’anziano.
Si sono identificate varie componenti da considerare sia nell’approccio diagnostico che in quello terapeutico: la complessità, la comorbilità psichiatrica e la comorbosita somatica, la fragilità nell’equilibrio comportamento/ambiente, infine la necessita del coinvolgimento del caregiver che può essere non solo fonte di cura per il malato, ma anche oggetto di sostegno, in associazione al malato. Si sono riassunti sia gli elementi conoscitivi legati alla EBM che alcuni elementi “narrativi” in tema sia di diagnosi che di trattament
Martina Drijverová and her literary works for children (author´s portrait)
No full textThis thesis Martina Drijverova and her literatur for children (the author´s portrait) is engaged in work of writer and screenwriter Martina Drijeverová. She is an excellent writer of literature for children. In the first part of this work her story writing is mentioned and the second part deals with her fairy-tale writing. The other author´s work written for children is in the third part. The conclusion of this thesis appreciates the author´s credit in literature for chidlren. Analysis of some books are available. The supplementary part is composed of autor´s biography and her photograph, some book covers, list of the autor´s work {--} televiews, radio plays and serials, audio tapes and CDs, stage plays, books written in Braille
HERStory Makers 2022: Martina Čagalj
No full textMartina Čagalj is a PhD candidate at the University of Split studying seaweeds as a potential source of bioactive compounds. She took part in HERStory Makers 2022.What is HERStory Makers?HERStory Makers is a social media competition for female-identifying early career researchers to share their research, their career journeys, and to inspire the next generation. Winners are selected by public vote. HERStory Makers is also part of EXPLORATHON, Scotland's contribution to European Researchers' Night.In 2022-23, EXPLORATHON was supported by the Engineering & Physical Sciences Research Council [grant number EP/X020894/1].Author contributions to contentMartina Čagalj conceived, planned, and recorded the video content. Kirsty Ross edited the video content to insert HERStory Maker credits, add subtitles, and maintain video length below Twitter/X limit of 2 mins and 20 secs, prior to scheduling the social media posts.</p
The metal-nonoate Ni(SalPipNONO) inhibits in vitro tumor growth, invasiveness and angiogenesis
No full textNitric oxide (NO) exerts conflicting effect on tumor growth and progression,
depending on its concentration. We aimed to characterize the anti-cancer activity
of a new NO donor, Ni(SalPipNONO) belonging to the class of metal-nonoates, in
epithelial derived tumor cells, finally exploring its antiangiogenic properties. Tumor
epithelial cells were screened to evaluate the cytotoxic effect of Ni(SalPipNONO),
which was able to inhibit cell proliferation in a dose dependent manner, being more
effective than the commercial DETA/NO. The human lung carcinoma cells A549 were
chosen as model to study the anti-cancer mechanisms exerted by the compound. In
these cells, Ni(SalPipNONO) inhibited clonogenicity and cell invasion, while promoting
apoptosis. The antitumor activity was partly due to NO-cGMP dependent pathway,
contributing to reduced cell number and apoptosis, and partly to the salicylaldehyde
moiety and reactive oxygen species (ROS) activated ERK1/2 signaling converging
on p53 dependent caspase-3 cleavage. An additional contribution by downstream
cycloxygenase-2 (COX-2) derived cyclopentenones may explain the tumor inhibitory
activities. As NO has been described to affect tumor angiogenesis, we checked this
activity both on tumor and endothelial cell co-cultures and in Matrigel in vivo assay.
Our data document that Ni(SalPipNONO) was able to both reduce angiogenic factor
expression by tumor cells acting on hypoxia inducible factor-1α (HIF-1 α) level, and
endothelial cell functions related to angiogenesis. Collectively, these data confirm the
potential use of NO donors and in particular Ni(SalPipNONO) acting through multiple
mechanisms, as an agent to be further developed to be used alone or in combination
with conventional therapy
The role of data science in software development
No full textauthor: Martina WeberMasterarbeit Universität Innsbruck 201
The role of data science in software development
No full textauthor: Martina WeberMasterarbeit Universität Innsbruck 201
The role of data science in software development
No full textauthor: Martina WeberMasterarbeit Universität Innsbruck 201
Man kann nicht nicht vergleichen. Sprachvergleich und Sprachreflexion in einer integrierten Mehrsprachigkeitsdidaktik mit Englisch als Brückensprache
No full textPlurilinguism and plurilingual didactics have gained an important position in scientific discussion, even though interlingual and integrated approaches to teaching practice are still lacking. After a short description of various approaches, all based on language comparison and metalingual reflection, the author suggests adopting English as a bridge-language in plurilingual didactics, independent of the language family and languages studied. On the basis of various learner profiles, the author illustrates the benefit of using English as an element of language comparison and reflection in the learning process of other languages
Cross-talk between endogenous H2S and NO accounts for vascular protective activity of the metal-nonoate Zn(PipNONO)Cl
No full textNitric oxide (NO) and hydrogen sulfide (H2S) are now recognized as gaseous transmitters with many cardiovascular protective properties. The present study concerns the possibility that NO donors can also function through endogenous activation of NO and H2S pathways. Based on the previous characterization of a novel metal-nonoate, Ni(PipNONO)Cl, our aim was: 1) to study the effects of a zinc based compound, Zn(PipNONO)Cl, on vascular endothelial and smooth muscle cells, and 2) to assess the role and interplay between endogenous NO and H2S promoted by the nonoate.
Zn(PipNONO)Cl completely reproduced the vasodilation elicited by Ni(PipNONO)Cl. In the presence of endothelium, preincubation with Zn(PipNONO)Cl sensitized the intima to acetylcholine-induced vasodilation. When tested on cultured endothelial cells, Zn(PipNONO)Cl promptedPI-3K/Akt- and MAPK/ERK1/2-mediated survival. Nitrite levels indicated fast NO release (due to the molecule) and delayed (1-6 h) NO production linked to PI-3K/Akt-dependent eNOS activation. In the same time frame (1-6 h), significant CSE-dependent H2S levels were detected in response to Zn(PipNONO)Cl. The mechanisms responsible for H2S increase seemed to depend on the NONO moiety/sGC/cGMP pathway and zinc-associated ROS production. Our results indicate that endogenous H2S and NO were produced after fast NO release from Zn(PipNONO)Cl, contributing to the vascular endothelium protective effect. The effect was partially reproduced on smooth muscle cells, where Zn(PipNONO)Cl inhibited cell proliferation and migration.
In conclusion, vasorelaxant effects, with complementary activities on endothelium and smooth muscle cells, are elicited by the novel metal-nonoate Zn(PipNONO)Cl
Author Correction: Gluten consumption and inflammation affect the development of celiac disease in at-risk children
No full textThe original version of this Article contained an error in the spelling of the authors Renata Auricchio, Ilaria Calabrese, Martina Galatola, Donatella Cielo, Fortunata Carbone, Marianna Mancuso, Giuseppe Matarese, Riccardo Troncone, Salvatore Auricchio & Luigi Greco which were incorrectly given as Auricchio Renata, Calabrese Ilaria, Galatola Martina, Cielo Donatella, Carbone Fortunata, Mancuso Marianna, Matarese Giuseppe, Troncone Riccardo, Auricchio Salvatore & Greco Luigi. The original article has been corrected
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