1,721,088 research outputs found
Clinical review: Noninvasive ventilation in the clinical setting--experience from the past 10 years
No full textThis brief review analyses the progress of noninvasive ventilation (NIV) over the last decade. NIV has gained the dignity of first line intervention for acute exacerbation of chronic obstructive pulmonary disease, assuring reduction of the intubation rate, rate of infection and mortality. Despite positive results, NIV still remains controversial as a treatment for acute hypoxemic respiratory failure, largely due to the different pathophysiology of hypoxemia. The infection rate reduction effect achieved by NIV application is crucial for immunocompromised patients for whom the endotracheal intubation represents a high risk. Improvements in skills acquired with experience over time progressively allowed successful treatment of more severe patients.
PMID: 15693991 PMCID: PMC1065090 DOI: 10.1186/cc293
Clinical review: noninvasive ventilation in the clinical setting-experience from the past 10 years
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A Word of Caution on the Danger of Noninvasive Respiratory Support During Sepsis
No full textWe read with great interest the recently published study by Xu et al (1)
in Critical Care Medicine. Among immunocompromised patients
with sepsis requiring respiratory support, the authors demonstrated
that prolonged noninvasive ventilation (NIV) before transition to invasive mechanical
ventilation was associated to higher risk of in-hospital mortality. The
risk increased in NIV patients who experienced longer time to intubation, suggesting
a dose-response relationship
Diagnostic accuracy of bedside ultrasonography in the ICU: feasibility of detecting pulmonary effusion and lung contusion in patients on respiratory support after severe blunt thoracic trauma
No full textBACKGROUND:
Blunt thoracic trauma is a major concern in critically ill patients. Repeated lung diagnostic evaluations are needed in order to follow up the clinical situation and the results of the therapeutic strategies. The aim of this prospective clinical study was to evaluate the possible role of lung ultrasound (LU) compared with bedside radiography (CXR) and computed tomography (CT) used as the gold standard in the evaluation of trauma patients admitted to the intensive care unit with acute respiratory failure.
METHOD:
A total of 15 thoracic trauma patients were studied at intensive care unit (ICU) arrival (T1) and 48 h later (T2) with CT, CXR and LU. We evaluated the presence of pleural effusion (PE) and lung contusion (LC). For this purpose the lung parenchyma was divided into 12 regions so that we could compare 180 lung regions at T1 and T2, respectively.
RESULTS:
Sensitivity of ultrasound was 0.94 for PE and 0.86 for LC while specificity 0.99 and 0.97, respectively. The likelihood ratio was 94 (rho(+)) and 0.06 (rho(-)) for PE and 28.6 (rho(+)) and 0.14 (rho(-)) for LC.
CONCLUSIONS:
Ultrasound provides a reliable noninvasive, bedside method for the assessment of chest trauma patients with acute respiratory failure in the ICU
Biomarkers in sepsis: towards precision medicine for the prevention of adverse outcomes
No full textBiomarkers in sepsis: towards precision medicine for the prevention of adverse outcomes
High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure: Need for Patient Phenotyping?
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Renin-angiotensin system dysregulation in critically ill patients with acute respiratory distress syndrome due to COVID-19: a preliminary report
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Utilization of small changes in serum creatinine with clinical risk factors to assess the risk of AKI in critically lll adults
No full textDisease biomarkers require appropriate clinical context to be used effectively. Combining clinical risk factors, in addition to small changes in serum creatinine, has been proposed to improve the assessment of AKI. This notion was developed in order to identify the risk of AKI early in a patient's clinical course. We set out to assess the performance of this combination approach
When targeted therapy for cancer leads to ICU admission. RETRO-TARGETICU multicentric study
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