1,721,099 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity .
No full textBackground. In the last two decades, obesity has assumed the form of a pandemic, often related to the development of cardiovascular diseases (CVD) and strokes. There is a worldwide emergency that requires the development of novel and safer anti-obesity treatments. Rimonabant, a well-known inverse agonist of the type-1 cannabinoid receptor (CB1), associated with lifestyle modifications was successfully engaged in the control of obesity by reducing appetite and weight gain. Though this drug has shown to be effective to control body weight and to manage obesity, it has been withdrawn from the market due to its important side effects. Thus, a novel drug able to provide the same therapeutic efficacy without the dangerous side efficacy without the dangerous side effects is an urgent need. We report a series of lonidamine joined Leu, tert-Leu and Val amino acids with different C-terminal functional groups (LONI1-4,11, Figure 1) designed as hybrids of Fubinaca family compounds and Rimonabant, as novel compounds endowed with orexant/anorexant activity.
Methods. We evaluated the orexant/anorexant activity of LONI1-4,11 in the feeding test using CD-1 male mice after intraperitoneal (i.p.) administration (10 mg/kg). For a LONI11 formalin test and a tail flick test after an administration by the subcutaneous (s.c.,30–100 μg/20 μL) and intracerebroventricular (i.c.v.,10 μg/10 μL) routes, respectively, were also carried out in mice to investigate the antinociceptive property at the central and peripheral levels. Furthermore, Zymosan-induced edema (s.c., 100 μg/20 μL) and hyperalgesia (s.c., 100 μg/20 μL) assays were also performed to estimate the anti-inflammatory activity of LONI11 in mice model.
Results. We observed a significant orexant effect for LONI11 and an intense anorexant effect for LONI2 and LONI4 (Figure 2). LONI11 at the doses of 10 μg/10 μL and 100 μg/20 μL produced a slight antinociceptive effect after i.c.v. and s.c. injections, respectively, in tail flick test (Figure 3, left panel) and in formalin test (Figure 3, right panel). In zymosan-induced edema (Figure 4, left panel) and hyperalgesia (Figure 4, right panel), LONI11 reduced the percent of paw volume increase and paw latency after s.c. administration, also suggesting a possible peripheral anti-inflammatory activity.
Conclusions. These results could be useful as a starting point to optimize the pharmacological properties of rimonabant/Fubinaca hybrids and to better understand the molecular mechanism below their biological profile. An understanding of all the neuroendocrine networks and their roles in the hypothalamus to regulate the feeding behaviour could lead to the development of novel and safer approaches to manage the main nutritional disorders
N-Lauroyl sarcosine sodium salt as corrosion inhibitor for type 1518 steel in neutral saline environment
No full textThe influence of the sodium salt of N-Lauroyl sarcosine (NLS) on corrosion of a manganese steel was studied in aerated, nearly neutral saline solutions at room temperature and under various hydrodynamic conditions.
The inhibitive efficiency of NLS was examined using gravimetric tests, polarization curves and electrochemical impedance spectroscopy (EIS).
NLS slowed the corrosion phenomena, either generalized or localized, that occured on steel, but only at high rotation speed of the rotating cylinder electrode (RCE).
The mechanism of action eas anodic and probably resulted from the precipitation of an insoluble product on the anodic areas
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