5,916 research outputs found
Audiomobiles, Sculptures and Conundrums
No full textRoberto Gerhard was a pioneer of electronic music in England creating a number of substantial concert, theatre and radio works from as early as 1954. Gerhard’s electronic music is one of the richest repositories for understanding the development of the composer’s late compositional technique. Apart from the Symphony no.3, ‘Collages’, none of Gerhard’s electronic music is published. This paper will discuss aspects of Gerhard’s electronic music, focusing on Audiomobiles (1958-59) and Sculptures (1963)
Roberto Gerhard’s Sound Compositions: A Historical-Philological Perspective. Archive, Process, Intent and reenactment
No full textThis research advances the current state of knowledge in the field of early tape music both empirically and methodologically. The purpose of this study is to evaluate the impact that the electronic medium exerted in the musical thinking of Roberto Gerhard, one of the most outspoken, prolific and influential composers in the Spanish diaspora whose musical legacy, for the most part unknown, is a major landmark in the early history of electroacoustic music. Gerhard’s personal tape collection, one of the largest historical archives of its kind reported in the literature, is exceptional for both its antiquity (50+-year-old tapes) and its abundance of production materials. Through the digitisation and analysis of the composer’s tape collection this research argues that the empirical study of audio documents sets out a basis for a broader understanding of textual processes. More specifically, the research demonstrates that the reconstruction of works based on magnetic tape sketches is a powerful method to advance the understanding of early tape music. This research also examines Gerhard’s sound compositions in relation to the post-war context in which they were composed. Finally, this research presents performance documentation that proposes an approach to the electroacoustic music repertoire in which creativity is not at odds with rigor and critical discernment demonstrating that archival study can be closely aligned to the concept of re-enactment
Filologia editoriale, Roberto Calasso in dialogo con Paola Italia e Francisco Rico
No full textPaola Italia e Francisco Rico intervengono sul libro di Roberto Calasso, presidente e fondatore di Adelphi Edizioni, L'impronta dell'editore, e discutono di problemi di filologia delle forme editoriali, dal punto di vista dell'autore, del lettore e dell'editore.Paola Italia and Francisco Ricos interview Roberto Calasso, Publisher, Writer, and Founder of Adelphi Edizioni, about his book: L'impronta dell'editore, talking about philology, publishing and editing, from the author, the reader and the publisher's point of view
Roberto Tibau and the process of making architecture
No full textEste estudo documenta a vida e a obra de Roberto José Goulart Tibau (1924-2003), arquiteto brasileiro. O objetivo fundamental - e mais importante - é reunir informações sobre os projetos e obras mais significativos desenvolvidos durante sua atividade profissional, tornando-os acessíveis através dessa pesquisa. O trabalho baseou-se em pesquisa bibliográfica, levantamento e registro das obras e projetos realizados, currículo profissional, e depoimento de Tibau, concedido ao autor, em 1998. Em Roberto Tibau e o fazer arquitetura são descritos os caminhos percorridos pelo arquiteto; o contexto histórico de sua formação e atuação profissional; a relação de sua produção arquitetônica com outras obras da época; e eventuais referências projetuais utilizadas na criação dos seus projetos. Este trabalho vem preencher uma lacuna bibliográfica considerável, trazendo à luz, a obra deste significativo arquiteto, que dedicou sua vida ao trabalho na prancheta, na qual deixou sua marca de humanista.This study documents the life and work of Roberto José Goulart Tibau (1924-2003), a Brazilian architect. It aims to collect information about the most significant projects developed during the years of his professional career, which will become available through this research. The present study based on bibliographical research, examination and registration of the projects executed by the architect, his resumé, and his testimonial to the author of this research, in 1998. In Roberto Tibau and the process of making architecture there is a description of the ways in which his projects were conceived; the historical context through his professional activity since graduation, the relation between his own production and the production of other architects of the same period, and the projecting references used for his creations. This research is also an attempt to fill a signicant bibliographical gap of architecture history in Brazil by bringing to light the work of this relevant architect, who dedicated his life to working on his drawing table, leaving to us his humanistic style
Roberto Bolaño, la memoria antiheroica del exilio chileno
No full textThis article discusses the personality and the work of the Chilean writer Roberto Bolaño in an attempt to expand on the relationship between the author and his homeland Chile. Even though Bolaño left Chile at an early age and lived in many countries throughout his life, he tried to regain his roots as reflected in the novels about the Chilean dictatorship, Estrella distante and Nocturno de Chile. The author also attempts to vindicate his own origin in his literary alterego Arturo Belano. Thus, this article will highlight and analyse the relation between Roberto Bolaño and Chile through the antiheroic vision given not only to the characters but also to the settings of the narratives.Este artículo se centra en la personalidad del escritor chileno Roberto Bolaño y su obra para profundizar en la relación existente entre el autor y Chile, su país de origen. Pese a haber abandonado el país siendo muy joven y a haber residido en otros países a lo largo de su vida, Bolaño nunca perdió el interés por recuperar sus raíces chilenas tanto como lo reflejan las novelas que dedica a la dictadura chilena, Estrella distante y Nocturno de Chile sobre todo, así como por reivindicar su propio origen a través de su álter ego literario Arturo Belano. En este artículo se señalarán y analizarán estas relaciones entre Roberto Bolaño y Chile a través de la visión antiheroica que el autor confiere tanto a los ambientes como a los personajes que articulan su narrativa
Carcinoide timico in paziente affetta da sindrome da neoplasie endocrine multiple di tipo 1 (MEN1): ruolo dello screening radiologico e medico-nucleare
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Neuroendocrine Tumors and Survival Rates in Multiple Endocrine Neoplasia Type 1 Patients: Impact of Gender Difference
No full textIntroduction: Multiple endocrine neoplasia type 1 (MEN-1) is the most common inherited syndrome associated with NET development and gender-specific differences are emerging in neuroendocrine tumors (NETs). This study aimed to analyze gender difference in a single cohort of MEN-1 patients focusing on duodeno-pancreatic (DP)-NET and survival rates. Methods: MEN-1 patients referred to the Endocrinology Unit of the "Federico II"University of Naples, ENETS CoE, were retrospectively evaluated. Results: Among 100 MEN-1 patients enrolled, 59 (59%) were female and 41 (41%) male, and mean age at diagnosis was 39.4 years (range 5-86). No statistically significant association was identified between MEN-1 clinical manifestations and gender (primary hyperparathyroidism [PHPT] p: 1.0, DP-NET p: 0.83, pituitary adenoma [PA] p: 0.84, lung NET p: 0.64, and thymic NET p: 0.10), and similarly, age at diagnosis of MEN-1 and its individual manifestations was similar between genders. Survival analysis revealed no statistically significant difference between genders in DP-NET patients regarding progression disease p: 1.0 and death p: 1.0. Mean progression-free survival (PFS) of patients with DP-NET was 98.6 months (range 3-288), and mean overall survival (OS) was 130.1 months (range 3-444 months), without differences between genders (PFS p: 0.67 and OS p: 0.60). The Kaplan-Meier survival curves for PFS and OS showed no differences between genders (PFS p: 0.92; OS p: 0.87). Conclusion: In this MEN-1 cohort, no gender differences in the occurrence of PHPT, PA, DP-NET, lung NET, and thymic NET, nor in survival outcomes including PFS and OS within the DP-NET subcohort, emerged. Therefore, this study supports similar screening and follow-up for both male and female MEN-1 patients
Role of FGF System in Neuroendocrine Neoplasms. Potential Therapeutic Applications
No full textNeuroendocrine neoplasms (NENs) are a heterogeneous group of tumors originating from neuroendocrine cells dispersed in different organs. Receptor tyrosine kinases are a subclass of tyrosine kinases with a relevant role in several cellular processes including proliferation, differentiation, motility and metabolism. Dysregulation of these receptors is involved in neoplastic development and progression for several tumors, including NENs. In this review, we provide an overview concerning the role of the fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) system in the development and progression of NENs, the occurrence of fibrotic complications and the onset of drug-resistance. Although no specific FGFR kinase inhibitors have been evaluated in NENs, several clinical trials on multitarget tyrosine kinase inhibitors, acting also on FGF system, showed promising anti-tumor activity with an acceptable and manageable safety profile in patients with advanced NENs. Future studies will need to confirm these issues, particularly with the development of new tyrosine kinase inhibitors highly selective for FGFR
Recent advances and future challenges in the diagnosis of neuroendocrine neoplasms
No full text: Neuroendocrine neoplasms (NEN) are a heterogeneous group of malignancies with increasing incidence, whose diagnosis is usually delayed, negatively impacting on patients' prognosis. The latest advances in pathological classifications, biomarker identification and imaging techniques may provide early detection, leading to personalized treatment strategies. In this narrative review the recent developments in diagnosis of NEN are discussed including progresses in pathological classifications, biomarker and imaging. Furthermore, the challenges that lie ahead are investigated. By discussing the limitations of current approaches and addressing potential roadblocks, we hope to guide future research directions in this field. This article is proposed as a valuable resource for clinicians and researchers involved in the management of NEN. Update of pathological classifications and the availability of standardized templates in pathology and radiology represent a substantially improvement in diagnosis and communication among clinicians. Additional immunohistochemistry markers may now enrich pathological classifications, as well as miRNA profiling. New and multi-analytical circulating biomarkers, as liquid biopsy and NETest, are being proposed for diagnosis but their validation and availability should be improved. Radiological imaging strives for precise, non-invasive and less harmful technique to improve safety and quality of life in NEN patient. Nuclear medicine may benefit of somatostatin receptors' antagonists and membrane receptor analogues. Diagnosis in NEN still represents a challenge due to their complex biology and variable presentation. Further advancements are necessary to obtain early and minimally invasive diagnosis to improve patients' outcomes
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