1,720,959 research outputs found
Allestimento e museografia. Dieci anni di corso
No full textNel volume l'autore raccoglie l'attività' didattica da lui svolta nel corso di Museografia del Prof. Franco Minissi prolungatasi in dieci anni. Gli argomenti sono relativi a tematiche di interventi di Restauro nell'ottica della musealizzazione. All'interno il volume ospita scritti a firma di Sandro Ranellucci e Franco Minissi
Museografia
No full textNel volume l'autore riferisce di una prolungata attività' d'insegnamento condotta insieme a Franco Minissi nel corso di Museografia di Roma La Sapienza. Oltre alla abbondante documentazione di esperienze dettagliate e significative, che rientrano nell'area del recupero del patrimonio architettonico a fini museografici, la trattazione si articola su temi di varia natura dal monumento al territorio presentando un ricco panorama di possibili situazioni reali in cui la disciplina del restauro dei monumenti può' trovare campo di applicazione
Sintesi dei lattoni del whisky e del cognac e loro analoghi attraverso metatesi dei sistemi diolefinici e riduzioni diastereoselettive
No full textSynthesis of Whisky and Cognac Lactone and Their analogues through metathesis of Diolefinic Systems abd Diastereoselective Reductions
No full textSynthesis of α,β-unsaturated 4,5-disubstituted γ-lactones via ring-closing metathesis catalyzed by the first-generation Grubbs' catalyst
No full text4-Methyl-5-alkyl-2(5H)-furanones have been prepared by ruthenium-catalyzed ring-closing metathesis of the suitable methallyl acrylates. Despite the electron deficiency of the conjugated double bond and of the gem-disubstitution of the allylic alkene moiety in the starting acrylates, the first-generation Grubbs' catalyst I proved to be an effective promoter for the ring closure, affording the expected butenolides in good to high yields
In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors
Full text linkAmong matrix metalloproteinases (MMPs), gelatinases MMP-2 (gelatinase A) and MMP-9 (gelatinase B)
play a key role in a number of physiological processes such as tissue repair and fibrosis. Many evidences
point out their involvement in a series of pathological events, such as arthritis, multiple sclerosis, cardiovascular
diseases, inflammatory processes and tumor progression by degradation of the extracellular
matrix. To date, the identification of non-specific MMP inhibitors has made difficult the selective targeting
of gelatinases. In this work we report the identification, design and synthesis of new gelatinase inhibitors
with appropriate drug-like properties and good profile in terms of affinity and selectivity. By a
detailed in silico protocol and innovative and versatile solid phase approaches, a series of 4-thiazolydinyl-
N-hydroxycarboxyamide derivatives were identified. In particular, compounds 9a and 10a showed
a potent inhibitory activity against gelatinase B and good selectivity over the other MMP considered in
this study. The identified compounds could represent novel potential candidates as therapeutic agents
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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