4,000 research outputs found
miR-9-5p IN NEURONAL DENDRITIC REMODELING: THE ROLE OF STRESS
No full textmiR-9-5p IN NEURONAL DENDRITIC REMODELING: THE ROLE OF STRESSmiR-9-5p IN NEURONAL DENDRITIC REMODELING: THE ROLE OF STRES
An in vitro stress model of primary oligodendrocytes from anxious and non-anxious mouse strains
No full textmiRNA Editing: New Insights into the Fast Control of Gene Expression in Health and Disease
No full textPost-transcriptional modifications are essential mechanisms for mRNA biogenesis and function in eukaryotic cells. Beyond well-characterized events such as splicing, capping, and polyadenylation, there are several others, as RNA editing mechanisms and regulation of transcription mediated by miRNAs that are taking increasing attention in the last years. RNA editing through A-to-I deamination increases transcriptomic complexity, generating different proteins with amino acid substitution from the same transcript. On the other hand, miRNAs can regulate gene expression modulating target mRNA decay and translation. Interestingly, recent studies highlight the possibility that miRNAs might undergo editing themselves. This mainly translates in the degradation or uncorrected maturation of miRNAs but also in the recognition of different targets. The presence of edited and unedited forms of the same miRNA may have important biological implications in both health and disease. Here we review ongoing investigations on miRNA RNA editing with the aim to shed light on the growing importance of this mechanism in adding complexity to post-transcriptional regulation of gene expression
Stress, microRNAs, and stress-related psychiatric disorders: an overview
No full textStress is a major risk factor for psychiatric disorders. During and after exposure to stressors, the stress response may have pro- or maladaptive consequences, depending on several factors related to the individual response and nature of the stressor. However, the mechanisms mediating the long-term effects of exposure to stress, which may ultimately lead to the development of stress-related disorders, are still largely unknown. Epigenetic mechanisms have been shown to mediate the effects of the environment on brain gene expression and behavior. MicroRNAs, small non-coding RNAs estimated to control the expression of about 60% of all genes by post-transcriptional regulation, are a fundamental epigenetic mechanism. Many microRNAs are expressed in the brain, where they work as fine-tuners of gene expression, with a key role in the regulation of homeostatic balance, and a likely influence on pro- or maladaptive brain changes. Here we have selected a number of microRNAs, which have been strongly implicated as mediators of the effects of stress in the brain and in the development of stress-related psychiatric disorders. For all of them recent evidence is reported, obtained from rodent stress models, manipulation of microRNAs levels with related behavioral changes, and clinical studies of stress-related psychiatric disorders. Moreover, we have performed a bioinformatic analysis of the predicted brain-expressed target genes of the microRNAs discussed, and found a central role for mechanisms involved in the regulation of synaptic function. The complex regulatory role of microRNAs has suggested their use as biomarkers for diagnosis and treatment response, as well as possible therapeutic drugs. While, microRNA-based diagnostics have registered advancements, particularly in oncology and other fields, and many biotech companies have launched miRNA therapeutics in their development pipeline, the development of microRNA-based tests and drugs for brain disorders is comparatively slower
A Conversation with Jessica B. Harris
No full textA conversation with culinary historian and award-winning author Jessica B. Harris, moderated by Gabrielle Fulton Ponder
Jessica Stremer: Cook Prize 2024, Silver Medal Acceptance Speech
No full textAuthor Jessica Stremer gives an acceptance speech for Great Carrier Reef (Holiday House)https://educate.bankstreet.edu/cook/1013/thumbnail.jp
Jessica Pierce: The Last Walk: Caring for Our Animal Companions
No full textBioethicist and author Jessica Pierce will discuss end-of-life care, dying, and euthanasia in the lives of our companion animals.https://thekeep.eiu.edu/humanitiescenter_authenticity1314/1003/thumbnail.jp
Providence College Faculty Author Series 2014-2015: Dr. Jessica Mulligan
No full textIn this installment of the Faculty Authors Series, Dr. Jessica Mulligan of the Health Policy & Management department discusses her book Unmanageable Care: An Ethnography of Health Care Privatization in Puerto Rico - elucidating the history and contemporary state of the Puerto Rican healthcare system
Providence College Faculty Author Series 2014-2015: Dr. Jessica Mulligan
No full textIn this installment of the Faculty Authors Series, Dr. Jessica Mulligan of the Health Policy & Management department discusses her book Unmanageable Care: An Ethnography of Health Care Privatization in Puerto Rico - elucidating the history and contemporary state of the Puerto Rican healthcare system
Jessica Hagedorn, 19th Annual ODU Literary Festival
No full textJessica Hagedorn Born and raised in the Philippines, Jessica Hagedorn is well-known as a performance artist, poet, and playwright. She is the author of the novel Dogeaters (Penguin), which was nominated for the National Book Award. Hagedorn wrote the screenplay for Fresh Kill, an independent first feature film directed and produced by Shu Lea Cheang and has collaborated on film projects, Color Schemes and Those Fluttering Objects of Desire. Her multimedia theater pieces include Teenytown, The Art of War: Nine situations, and Holy Food. Hagedorn is the recipient of a 1994 Lila Wallace Reader’s Digest Writers Award, and a 1995 NEA Creative Writing Fellowship. Her new novel, The Gangster of Love has been recently released by Houghton Mifflin
- …
