186,213 research outputs found
Learning to quantify uncertainty in off-target activity for CRISPR guide RNAs
No full text<p>CRISPR-based genome editing technologies have revolutionised the field of molecular biology,<br>offering unprecedented opportunities for precise genetic manipulation. However, off-target effects remain<br>a significant challenge, potentially leading to unintended consequences and limiting the applicability of<br>CRISPR-based genome editing technologies in clinical settings. Current literature predominantly focuses<br>on point predictions for off-target activity, which may not fully capture the range of possible outcomes and<br>associated risks. Here, we present crispAI, a neural network architecture-based approach for predicting<br>uncertainty estimates for off-target cleavage activity, providing a more comprehensive risk assessment<br>and facilitating improved decision-making in single guide RNA (sgRNA) design. Our approach makes<br>use of the count noise model Zero Inflated Negative Binomial (ZINB) to model the uncertainty in the<br>off-target cleavage activity data. In addition, we present the first-of-its-kind genome-wide sgRNA efficiency<br>score, crispAI-aggregate, enabling prioritization among sgRNAs with similar point aggregate predictions by<br>providing richer information compared to existing aggregate scores. We show that uncertainty estimates of<br>our approach are calibrated and its predictive performance is superior to state-of-the-art in silico off-target<br>cleavage activity prediction methods.</p>
Supplemental Material - Low energy repair of co-continuous metal-ceramic composites using electrodeposition
No full textSupplemental Material for Low energy repair of co-continuous metal-ceramic composites using electrodeposition by Mohammadreza Mahmoudi, Se Oh and Majid Minary-Jolandan in Journal of Composite Materials</p
Débuts et fins de siècles. Temps de mutation historico-culturelles dans l'Europe moderne et contemporaine. Textes réunis et publiés par Daniel Minary, 2000
No full textMichaud Claude. Débuts et fins de siècles. Temps de mutation historico-culturelles dans l'Europe moderne et contemporaine. Textes réunis et publiés par Daniel Minary, 2000. In: Dix-huitième Siècle, n°33, 2001. L'Atlantique, sous la direction de Marcel Dorigny . p. 613
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Adoption d'un décret qui accorde un secours au citoyen Claude-Antoine Minary, acquitté au Tribunal révolutionnaire, lors de la séance du 4 frimaire an III (24 novembre 1794)
No full textDu Bois du Bais Louis-Thibault. Adoption d'un décret qui accorde un secours au citoyen Claude-Antoine Minary, acquitté au Tribunal révolutionnaire, lors de la séance du 4 frimaire an III (24 novembre 1794). In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome CII - Du 1er au 12 frimaire An III (21 novembre au 2 décembre 1794) Paris : CNRS éditions, 2012. p. 137
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Edward P. Wimberly, ITC, July 2011
No full textThis video is a conversation with Dr. Edward P. Wimberly. Dr. Wimberly talks about his book, "No Shame in Wesley's Gospel: A Twenty-First Century Pastoral Gospel". Brad Ost, AUC Woodruff Library, is the interviewer
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