1,721,037 research outputs found
Cell and molecular response to IORT treatment
No full textIonizing radiations (IRs) generated by intraoperative radiotherapy (IORT) treatment activates
both pro- and antiproliferative signal pathways producing an imbalance in cell fate decision regulated by
several genes and factors involved in cell cycle progression, survival and/or cell death, DNA repair and
inflammation. This paper describes the latest advances on cellular and molecular response to IR, highlighting
the most relevant research data from cell biology, gene expression profiling and epigenetic studies on
different tumor cell types. Understanding the cell molecular strategies to choose between death and survival,
after an irradiation-induced damage, opens new avenues for the selection of a proper therapy schedule, to
counteract cancer growth and preserve healthy surrounding tissue by radiation effects
Correlation between clinical and radiographic classification of osteoarthritis and SNPs linked to osteoarthritis susceptibility
No full textA family with segregation of an unbalanced translocation (7;13) (q36;q32) in three patients with severe mental retardation, microcephaly and dysmorphic features, detected by subtelomere FISH: genetic counselling and prenatal diagnosis
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
“Omics” of HER2-Positive Breast Cancer
No full textHER2/neu amplification/overexpression is the only somatic mutation widely considered to be a marker of
disease outcome and response to treatment in breast cancer. Pathologists have made large efforts to achieve
accuracy in characterizing HER2/neu status. The introduction of transtuzumab contributed to development of
additional measures to identify sensitive and resistant subclasses of HER2/neu-positive tumors. In this article,
we describe the latest advances in HER2/neu status diagnostic assessment and the most relevant research
emerging from ‘‘Omics’’ (genomics, epigenetics, transcriptomics, and proteomics) studies on HER2/neu-positive
breast cancer. A large quantity of biomarkers from different studies highlighted HER2/neu-positive specific
proliferation, cell cycle arrest, and apoptosis mechanisms, as well as immunological and metabolic behavior.
Major driver genes of tumor progression have had a candidate status (GRB7, MYC, CCND1, EGFR, etc.), even
though the main role for HER2/neu is largely recognized. Nonetheless, existing omics data and HER2/neupositive
molecular profiles seem to suggest that few proteogenomic alterations in HER2, EGFR, and PI3K
networks could significantly affect the effectiveness of transtuzumab. The systematic search of molecular alterations
in and across these pathways can help to select the most appropriate drug for a given patient based on
in-depth understanding of complexity in tumor biology
A type I interferon (IFN)-induced distal enhancer differentially regulates the P1 and P2 c-Myc promoters
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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