1,721,014 research outputs found
Restless legs syndrome: a new entity of neuropathic pain? Treatment with prolonged release oxycodone/naloxone combination
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Obstructive sleep apnea syndrome [La sindrome delle apnee ostruttive durante il sonno]
No full textThe obstructive sleep apnea syndrome (OSAS) is a sleep breathing disorder of considerable epidemiological impact and a well-documented risk factor for cardiovascular and cerebrovascular diseases, because of the close relationship with hypertension, endocrine and glyco-lipid metabolism impairments, thrombophilic state and systemic inflammation, as well as with obesity: between 40 and 60% of obese subjects have a sleep breathing disorder while about 70% of patients with OSAS are obese. This work, after pointing out the features of OSAS as a systemic disease, examines the key points of the optimal diagnosis and treatment of this sleep breathing disorder. Aiming to a desirable "personalization" of the treatment, different therapeutic instruments are available, ranging from behavioral measures, to orthodontic and ventilatory devices or surgical treatments. Anyway control of body weight is crucial for the otpimal treatment of an OSAS patient
Cyclic alternating pattern (CAP) as pace-maker of PLM in Nocturnal Frontal Lobe Epilepsy
No full textUltradian, homeostatic and microstructural modulation of ictal events in nocturnal frontal lobe epilepsy
No full textParadoxical insomnia: the role of CAP and arousals in sleep misperception
No full textObjective: The relationship between CAP parameters and subjective time perception during sleep in primary insomnia was investigated.
Patients and methods: Data collected from all-night PSG recordings of 20 patients with a diagnosis of paradoxical insomnia (misperceptors) were compared with those of 20 normal gender- and age-matched subjects (controls). Besides sleep staging, scoring measures included CAP parameters and EEG arousals.
Results: Patients and controls presented non-significant differences in the amounts of objective sleep time (464 min vs. 447 min) and objective sleep latency (9 min vs. 8 min). Compared to controls, misperceptors reported a significantly shorter time of Perceived sleep (285 min vs. 461 min) and a significantly longer duration of perceived sleep latency (51 min vs. 22 min). In spite of the 11 objective awakenings, misperceptors reported only 4 subjective awakenings, while controls described 2 of the 5 objective awakenings. Arousal index (31.7/h vs. 18.6/h) and total CAP rate (58.1% vs. 35.5%) were significantly higher in misperceptors. In the sleep period between objective and subjective sleep onset, CAP rate was 64.4% in misperceptors and 45.1% in controls (p < 0.002). Insomniacs showed significantly higher amounts of CAP rate in stage 1 (62.7% vs. 37.5%) and in stage 2 (53.3% vs. 33.1%). but not in slow wave sleep. CAP phase A2 subtypes were significantly increased in misperceptors (31% vs. 24%).
Conclusions: The study points out the topical role of enhanced activation and arousal instability not only in the first part of the night (mismatch between objective and subjective sleep onset) but also in the misperception of consecutive objective awakenings which are Subjectively grouped together as a single prolonged event
Acute shift of a case of moderate obstructive sleep apnea syndrome towards one of severe central sleep apnea syndrome after an ischemic stroke
No full textPolysomnographic features peculiar to nocturnal frontal lobe epilepsy: differential diagnosis with other sleep disorders
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