3,044 research outputs found
aE Journal 2015/2016: aE/INTECTURE innovating architecture
No full textThe graduation studio of Architectural Engineering focuses on the integration of (new) technology in architecture. For this purpose, the name aE/ INTECTURE® was devised, which will be developed further as a brand in the coming years. Students start with a technical fascination and translate this into an architectural concept, finally being able to implement this within the environment in a responsible way. ‘If technology is the answer, what is the question?‘ Under the guidance of a team of enthusiastic (guest) lecturers, students search for the dot on the horizon that is necessary for coming up with solutions that improve the quality of the built environment and make it more sustainable. In addition, either the ‘making‘ (make) or ‘the energy and material flow’ (flow) is used and applied as a basis in different contexts.Architectural Engineerin
Gastrointestinal stromal tumor (GIST) and ulcerative colitis
No full textA 57 year old woman, affected by Ulcerative Colitis (UC) in remission, was admitted to our unit with a history of episodic melena and progressive anemia. Computed tomography (CT) of the abdomen revealed a solid mass in the upper left pelvic cavity. After surgical laparotomy, the mass showed histological characteristics of a gastro intestinal stromal tumor.This report describes a GIST in a patient with extensive UC, which was in remission at the time of diagnosis. To our knowledge, this is the first report of an association of this type
Body weight increase during the first year of insulin treatment in patients with type 2 diabetes mellitus; a systematic review and meta-analysis of different insulin regimens
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The three-dimensional structure of two redox states of cyclophilin A from Schistosoma mansoni. Evidence for redox regulation of peptidyl-prolyl cis-trans isomerase activity
No full textTreatment of schistosomiasis, a widespread human parasitic disease caused by the helminth parasites of the genus Schistosoma, relies mainly on one chemotherapeutic agent, praziquantel, although several other compounds exert anti-parasitic effects. One such compound is the immunosuppressant cyclosporin A, which has been shown to significantly diminish worm burden in mice infected with Schistosoma mansoni. Given the well established interaction between cyclosporin A and the cyclophilin superfamily of peptidylprolyl cis-trans isomerases, we solved the structure of cyclophilin A from S. mansoni (SmCypA) by x-ray crystallography in the reduced and oxidized states at 1.5 and 1.8 A of resolution, respectively. Oxidized SmCypA contains a disulfide bridge between two C-terminal cysteines (Cys-122 and Cys-126). This is the first example of a cyclophilin containing this disulfide bridge. Parallel functional studies suggest a mechanism for regulation of SmCypA activity via oxidation of its thiol groups; in fact, whereas oxidized SmCypA is inactive, reduced SmCypA is an efficient isomerase active at nanomolar levels with a k(cat)/K(m) of 1.1 x 10(7) M(-1) s(-1), and it is inhibited by cyclosporin A (IC(50) of 14 +/- 4 nM). The lack of conservation of this cysteine couple within the CypA superfamily, their close proximity to the active site, and the importance of thiol groups for peptidyl-prolyl cis-trans isomerase activity render this structural feature a challenge for the development of alternative and more effective anti-schistosomiasis inhibitors and may in addition imply an alternative function of SmCypA in the schistosome
Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target.
No full textThe chemical advantage of sulfur over selenium: controlling the switching-in-function of the moonlighting behaviour of Peroxiredoxin.
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aE Journal 2017/2018: aE/Intecture innovating architecture
No full textDriven by the need to think differently about resources, energy, power generation, the choice of materials, and user involvement, we see the built environment in a new perspective. The program, Architectural Engineering, seeks for innovative and inspiring architectural solutions for social and environmental issues throughout all scales.To achieve this, innovation of the architectural challenge is high on our agenda. Innovation is more than just a technical improvement. How do you implement new current issues in modern architecture? We anticipate new energy, materials, and circularity. We also use the current environment of the metropolis and the countryside. We add new buildings, strengthen existing stock, and work on new components of buildings. From high to low tech. From digital to traditional, looking carefully to the context.Architectural Engineerin
Main motifs in the prose of the leftist author Kang Kyŏng-ae
No full textThe subject of this bachelor thesis is the life and work of the Korean writer Kang Kyǒng-ae, with a focus on her short prose. The aim of this thesis is an analysis of two works - Salt and Darkness - with attention to the context of the author's time. Nowadays, Kang Kyǒng-ae is considered a significant author of the 1930s and her works reflect the phenomenon of Korean emigrants in Manchuria. For a long time, leftist tendencies caused her prose to be neglected, which resulted in a considerably limited number of studies concerned with her work, in comparison to the number of studies about other writers. There are virtually no Czech studies of her work. The text of the thesis initially presents the timeframe of Kang's authorship and then analyzes select works of hers. The analysis of the works focuses on recurring motifs, which are put into a historical and social context. Keywords Kang Kyǒng-ae, Korean 1930s literature, leftist literature, Sogǔm, Ǒdu
Glutathione reductase and thioredoxin reductase at the crossroad: The structure of Schistosoma mansoni thioredoxin glutathione reductase.
No full textThioredoxin glutathione reductase (TGR) is a key flavoenzyme expressed by schistosomes that bridges two detoxification pathways crucial for the parasite survival in the host's organism. In this article we report the crystal structure (at 2.2 Å resolution) of TGR from Schistosoma mansoni (SmTGR), deleted in the last two residues. The structure reveals the peculiar architecture of this chimeric enzyme: the small Glutaredoxin (Grx) domain at the N-terminus is joined to the large thioredoxin reductase (TR) one via an extended complementary surface, involving residues not conserved in the Grx superfamily; the TR domain interacts with an identical partner via its C-terminal domain, forming a dimer with a twisted “W” shape. Although lacking the penultimate Selenocysteine residue (Sec), the enzyme is still able to reduce oxidized glutathione. These data update the interpretation of the interdomain communication in TGR enzymes. The possible function of this enzyme in pathogenic parasites is discussed
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