1,721,096 research outputs found
Rapid identification of PKU‐associated mutations by multiplex DGGE analysis of the PAH gene
No full textA system of five sets of multiplex polymerase chain reaction amplifications followed by denaturing gel electrophoresis analysis allows rapid analysis of all 13 exons of the phenylalanine hydroxylase gene
Prognosis of very young breast cancer patients
No full textThe relation between age of breast cancer patients at presentation and prognosis remains a matter of debate. Despite this controversy, more aggressive systemic treatments are claimed for younger patients. The population consisted of 1285 patients, which were divided in three age groups: (A) under the age of 35 (n = 63), (B) between 36 and 49 (448) and (C) older than 49 years (774). Clinical and pathological parameters, known to be related to prognosis, were recorded prospectively between 1983 and 1996 and related to the site of recurrence, disease free survival and survival. 41,27% of the patients from group A had recurrent disease compared to 25,7% for older patients (p=0,01). Confounding prognostic parameters were diameter, TNM-classification, location of the tumor within the breast, type of treatment and nodal status. However, these prognostic parameters did not explain why young patients did worse. The diameter of the tumor was even smaller with a mean of 2,49 cm within group A, compared to 2,74 and 3,21 cm for groups B and C respectively (p=0,001). Although the rate of locoregional relapse was identical in the three age groups, the younger age group had significantly more and earlier systemic recurrences (p=0,017). Overall survival was 73,53 (A), 84,65% (B) and 72,76 (C – p=0,004) at 5 years of follow-up. No prognostic parameter was significantly related to the risk of recurrence or survival. Younger breast cancer patients under the age of 35 have a significantly higher and earlier systemic recurrence compared to older age groups. This translates in a decreased survival 3 to 8 years after diagnosis. This poor prognosis can neither be explained nor predicted by routine clinical and pathological prognostic parameter
Prognosis of very young breast cancer patients
No full textThe relation between age of breast cancer patients at presentation and prognosis remains a matter of debate. Despite this controversy, more aggressive systemic treatments are claimed for younger patients. The population consisted of 1285 patients, which were divided in three age groups: (A) under the age of 35 (n = 63), (B) between 36 and 49 (448) and (C) older than 49 years (774). Clinical and pathological parameters, known to be related to prognosis, were recorded prospectively between 1983 and 1996 and related to the site of recurrence, disease free survival and survival. 41,27% of the patients from group A had recurrent disease compared to 25,7% for older patients (p=0,01). Confounding prognostic parameters were diameter, TNM-classification, location of the tumor within the breast, type of treatment and nodal status. However, these prognostic parameters did not explain why young patients did worse. The diameter of the tumor was even smaller with a mean of 2,49 cm within group A, compared to 2,74 and 3,21 cm for groups B and C respectively (p=0,001). Although the rate of locoregional relapse was identical in the three age groups, the younger age group had significantly more and earlier systemic recurrences (p=0,017). Overall survival was 73,53 (A), 84,65% (B) and 72,76 (C – p=0,004) at 5 years of follow-up. No prognostic parameter was significantly related to the risk of recurrence or survival. Younger breast cancer patients under the age of 35 have a significantly higher and earlier systemic recurrence compared to older age groups. This translates in a decreased survival 3 to 8 years after diagnosis. This poor prognosis can neither be explained nor predicted by routine clinical and pathological prognostic parameter
Type I alfa 1 collagen gene polymorphism is associated with bone density, muscle strength and susceptibility for fractures in elderly women.
No full textType I alfa 1 collagen gene polymorphism is associated with bone density, muscle strength and susceptibility for fractures in elderly women.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
