1,721,013 research outputs found
G protein-coupled receptors: Heterologous regulation of homologous desensitization and its implications
No full textTwo patterns of rapid desensitization have been characterized for G protein-coupled receptn:d: homologous desensitizeton, which mainly involves G protein-coupled receptor kineses and arrestins, and heterologous desensitization, which mainly involves protein kinases A IPKA) and C (PKC). In this review, Tsu T&en Chuang and colleagues discuss evidence to show that PKA and PKC can modify the functional state of the G protein-coupled receptor kinases/arrestin homologous desensitization machinery, providing a novel level of cross-talk in signal transduction. Studies on regulation of G protein-coupled receptor kinases and arrestins confirm that the functional state of this machinery may have important consequences far cellular responsiveness and may represent new targets for therapeutic strategies
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Identification of a short sequence highly divergent between beta-adrenergic-receptor kinases 1 and 2 that determines the affinity of binding to beta gamma subunits of heterotrimeric guanine-nucleotide-binding regulatory proteins
No full textA 28-residue peptide (peptide G), derived from the C-terminal (W643-S670) of the beta-adrenergic receptor kinase (beta ARK), was previously identified as the critical domain for binding to the beta gamma subunits fo the heterotrimeric guanine-nucleotide-binding regulatory protein (G beta gamma). We observed that the 18-amino-acid core of this domain is poorly conserved between beta ARK1 and beta ARK2 and so may provide the basis for differences in G beta gamma-binding properties. Specific antibodies raised against 18-residue peptides derived from the divergent sequences (peptides P1 and P2 for beta ARK1 and beta ARK2, respectively) competitively inhibited G beta gamma-activation of the related beta ARK subtype, confirming the involvement of this region in binding to G beta gamma. Peptides P1 and P2 inhibited G beta gamma-stimulated activity of both beta ARK1 and beta ARK2, with P2 being significantly more potent than P1 (IC50 of 179 +/- 5 mu M for P2 and > 500 mu M for P1). The 28-residue peptides G showed the same relative inhibitory activities (IC50 = 48 +/- 5 mu M for G2 and 146 +/- 8 mu M for G1). This relative order of potency G2 > G1 approximate to P2 > P1 was confirmed in a direct G beta gamma-binding assay. No binding selectivity for the beta 1, beta 2, beta 3 and beta 4 G beta subtypes was observed. The EC50 value for G beta gamma-activation of beta ARK1 was about double of that for beta ARK2, indicating a higher affinity between G beta gamma and beta ARK2, which is the expected result based on the findings with the peptides. These findings show that the 18-residue peptides P represent the shortest sequence of beta ARK that can bind to G beta gamma and provide a demonstration of a functional difference between the G beta gamma binding domains of beta ARK1 and beta ARK2
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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