26 research outputs found
Ependymal alterations in sudden intrauterine unexplained death and sudden infant death syndrome: possible primary consequence of prenatal exposure to cigarette smoking
No full textAbstract Background The ependyma, the lining providing a protective barrier and filtration system separating brain parenchyma from cerebrospinal fluid, is still inadequately understood in humans. In this study we aimed to define, by morphological and immunohistochemical methods, the sequence of developmental steps of the human ependyma in the brainstem (ventricular ependyma) and thoracic spinal cord (central canal ependyma) of a large sample of fetal and infant death victims, aged from 17 gestational weeks to 8 postnatal months. Additionally, we investigated a possible link between alterations of this structure, sudden unexplained fetal and infant death and maternal smoking. Results Our results demonstrate that in early fetal life the human ependyma shows a pseudostratified cytoarchitecture including many tanycytes and ciliated cells together with numerous apoptotic and reactive astrocytes in the subependymal layer. The ependyma is fully differentiated, with a monolayer of uniform cells, after 32 to 34 gestational weeks. We observed a wide spectrum of ependymal pathological changes in sudden death victims, such as desquamation, clusters of ependymal cells in the subventricular zone, radial glial cells, and the unusual presence of neurons within and over the ependymal lining. These alterations were significantly related to maternal smoking in pregnancy. Conclusions We conclude that in smoking mothers, nicotine and its derivatives easily reach the cerebrospinal fluid in the fetus, immediately causing ependymal damage. Consequently, we suggest that the ependyma should be examined in-depth first in victims of sudden fetal or infant death with mothers who smoke.</p
El Tlacuache Núm. 511 (2012). 511 Año 13 (2012) marzo. El Tlacuache
No full textCambio de estación y la migración de ballenas por Eduardo Corna Martínez. -Pasado y presente de los aprovechamientos costeros en la Península de Baja California por Ricardo Claudio Pacheco Bribiesca
A Si/SiGe based quantum dot with floating gates for scalability
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QCD/Vandersypen LabQN/Veldhorst LabQID/Ishihara LabQuantum Circuit Architectures and TechnologyQN/Vandersypen La
Exploring the search fund model : an evaluation of potential target companies in northern Italy
No full textLAUREA MAGISTRALESecondo i rapporti OCSE, le piccole e medie imprese (PMI) costituiscono la maggioranza delle imprese italiane, occupando quasi l'80% della forza lavoro nell'industria e nei servizi e generando circa i due terzi del fatturato e del valore aggiunto.
In questo scenario, i modelli di entrepreneurship through acquisition che si rivolgono alle piccole imprese come i Search Funds si rivelano di grande interesse, sia dal punto di vista accademico che da quello di business.
La prima sezione di questa tesi sarà dedicata a presentare il modello dei Search Funds in tutte le sue sfaccettature, facendo leva su approfondimenti provenienti dalle fonti più informate del settore.
La seconda sezione descriverà il framework, le metodologie e i risultati di una ricerca reale, condotta dall'autore della tesi, per un Search Fund con sede in Veneto.
La ricerca è partita da un ampio campione di aziende private con sede in Veneto, nel Nord Italia, e ha portato all'identificazione di quindici potenziali aziende target e di centocinquanta aziende comparables, dieci per ogni potenziale target. Le centosessantacinque aziende sono state poi analizzate in profondità attraverso note metriche di business, KPI e metodologie statistiche con l'obiettivo di fornire risultati significativi per aiutare il processo decisionale dei committenti del Search Fund.According to OECD reports, small and medium-sized enterprises (SMEs) make up the vast majority of Italian businesses, employing almost 80% of the workforce in industry and services and generating around two-thirds of turnover and value-added.
In this scenario, entrepreneurship through acquisition models that target small enterprises like Search Funds becomes of great interest, both from an academic standpoint and from a business one.
The first section of this thesis will be dedicated to presenting the Search Fund model in all its nuances, leveraging on insights coming from the most knowledgeable sources in the field.
The second section will describe the framework, the methodologies and the results of a real-world search, conducted by the thesis’ author, for a Search Fund based in Veneto.
The search started from a broad sample of privately held companies based in the Veneto region in Northern Italy and led to the identification of fifteen potential target companies as well as one hundred and fifty comparable companies, ten for each potential target. The one hundred and sixty-five companies were then analyzed in depth via well-known business measures, KPIs and statistical methodologies with the aim of providing significant results to help the decision-making process of the Search Fund principals
On-chip integration of Si/SiGe-based quantum dots and switched-capacitor circuits
No full textSolid-state qubits integrated on semiconductor substrates currently require at least one wire from every qubit to the control electronics, leading to a so-called wiring bottleneck for scaling. Demultiplexing via on-chip circuitry offers an effective strategy to overcome this bottleneck. In the case of gate-defined quantum dot arrays, specific static voltages need to be applied to many gates simultaneously to realize electron confinement. When a charge-locking structure is placed between the quantum device and the demultiplexer, the voltage can be maintained locally. In this study, we implement a switched-capacitor circuit for charge-locking and use it to float the plunger gate of a single quantum dot. Parallel plate capacitors, transistors, and quantum dot devices are monolithically fabricated on a Si/SiGe-based substrate to avoid complex off-chip routing. We experimentally study the effects of the capacitor and transistor size on the voltage accuracy of the floating node. Furthermore, we demonstrate that the electrochemical potential of the quantum dot can follow a 100 Hz pulse signal while the dot is partially floating, which is essential for applying this strategy in qubit experiments. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QCD/Vandersypen LabBusiness DevelopmentQCD/Veldhorst LabQCD/Scappucci LabQID/Ishihara LabQuantum Integration TechnologyQN/Vandersypen La
Simone de Beauvoir et Sigmund Freud
No full textConvaincu que tous les hommes ont une compréhension et une représentation géographiques du monde, l’auteur a choisi de sonder la pensée et la vie de deux personnages en apparence très éloignés de la géographie, mais qui, sans le savoir, ont beaucoup apporté à cette discipline. J’y vois comme un jeu de géographie culturelle où l’objet à découvrir se trouve entre les événements de l’existence des deux personnages et leur mise en scène comme grands écrivains féministe et père de la psychologie moderne. Avec Simone de Beauvoir, on peut explorer et raconter avec force et grande efficacité, et peut-être mieux que dans d’autres descriptions géographiques, des milieux culturels des plus différents ; l’Europe, l’Amérique, des groupes sociaux, des membres de la famille, des amis personnels. Avec Sigmund Freud, on célèbre plutôt la capacité à reconnaître les paysages extérieurs perçus par rapport aux paysages intérieurs formés dès la petite enfance, qui sont en quelque sorte des empreintes de lieux dont on ne peut taire la connaissance. Ces contributions constituent une richesse, non seulement pour la littérature et la psychologie, mais pour la connaissance et la représentation de la réalité : en cela, elles font partie du patrimoine géographique.Convinto che in molti saperi umani è presente una attenzione geografica alla comprensione e rappresentazione del mondo, l’ Autore sceglie di scandagliare il pensiero e la vita di due personaggi apparentemente molto lontani dalla Geografia, per identificare l’apporto che essi hanno dato, forse inconsapevolmente, a questa disciplina. E’ come un gioco di Geografia Culturale, dove l’ oggetto di cui scoprire il carattere geografico va ricercato tra le vicende della esistenza e dell’ opera di una grande scrittrice femminista e del padre della psicologia moderna. Di Simone de Beauvoir si esplora lo straordinario gusto di sperimentare e raccontare gli ambienti umani più diversi (europei, americani, sociali, familiari e personali), con una forza e una efficacia forse maggiore di molte altre descrizioni geografiche, più asettiche e meno coinvolgenti. Di Sigmund Freud si celebra invece la capacità di riconoscere quanto dei paesaggi esterni percepiti da ognuno, si debba ai paesaggi interni formatisi nell’ infanzia, o comunque patrimonio e lente conoscitiva insopprimibile. Questi contributi costituiscono una ricchezza, non solo per la letteratura e la psicologia, ma per la stessa conoscenza e rappresentazione della realtà tutta : meritano dunque di essere definiti anche patrimonio geografico.The author is persuaded that in many branches of the human knowledge there is a geographic attention to the comprehension and representation of the world, so he chooses to scan the thought and the life of two figures seemingly very far from Geography, in order to identify the contribution they, perhaps unaware, have given to this subject. It is like a game of Cultural Geography where the object we want to discover, the geographical character, is to be searched in the events of the life and the works of a great feminist writer and of the father of the modern psychology. For what concerns Simone de Beauvoir, the author explores the extraordinary taste of experimenting and telling about the most different human environments (European, American, social, familiar and personal) using a strength and an effectiveness that may result more remarkable than other more detached and less involving geographical descriptions. On the other side, Sigmund Freud is praised for his capability to recognize how much of the external landscapes perceived by everyone is due to the internal landscapes, developed during the childhood, or anyway, heritage and unsuppressible cognitive lens. These contributions are a treasure not only for Literature and Psychology but for the knowledge and the representation of the whole reality: they deserve, therefore the definition of geographic heritage
Simone de Beauvoir et Sigmund Freud
No full textConvaincu que tous les hommes ont une compréhension et une représentation géographiques du monde, l’auteur a choisi de sonder la pensée et la vie de deux personnages en apparence très éloignés de la géographie, mais qui, sans le savoir, ont beaucoup apporté à cette discipline. J’y vois comme un jeu de géographie culturelle où l’objet à découvrir se trouve entre les événements de l’existence des deux personnages et leur mise en scène comme grands écrivains féministe et père de la psychologie moderne. Avec Simone de Beauvoir, on peut explorer et raconter avec force et grande efficacité, et peut-être mieux que dans d’autres descriptions géographiques, des milieux culturels des plus différents ; l’Europe, l’Amérique, des groupes sociaux, des membres de la famille, des amis personnels. Avec Sigmund Freud, on célèbre plutôt la capacité à reconnaître les paysages extérieurs perçus par rapport aux paysages intérieurs formés dès la petite enfance, qui sont en quelque sorte des empreintes de lieux dont on ne peut taire la connaissance. Ces contributions constituent une richesse, non seulement pour la littérature et la psychologie, mais pour la connaissance et la représentation de la réalité : en cela, elles font partie du patrimoine géographique.Convinto che in molti saperi umani è presente una attenzione geografica alla comprensione e rappresentazione del mondo, l’ Autore sceglie di scandagliare il pensiero e la vita di due personaggi apparentemente molto lontani dalla Geografia, per identificare l’apporto che essi hanno dato, forse inconsapevolmente, a questa disciplina. E’ come un gioco di Geografia Culturale, dove l’ oggetto di cui scoprire il carattere geografico va ricercato tra le vicende della esistenza e dell’ opera di una grande scrittrice femminista e del padre della psicologia moderna. Di Simone de Beauvoir si esplora lo straordinario gusto di sperimentare e raccontare gli ambienti umani più diversi (europei, americani, sociali, familiari e personali), con una forza e una efficacia forse maggiore di molte altre descrizioni geografiche, più asettiche e meno coinvolgenti. Di Sigmund Freud si celebra invece la capacità di riconoscere quanto dei paesaggi esterni percepiti da ognuno, si debba ai paesaggi interni formatisi nell’ infanzia, o comunque patrimonio e lente conoscitiva insopprimibile. Questi contributi costituiscono una ricchezza, non solo per la letteratura e la psicologia, ma per la stessa conoscenza e rappresentazione della realtà tutta : meritano dunque di essere definiti anche patrimonio geografico.The author is persuaded that in many branches of the human knowledge there is a geographic attention to the comprehension and representation of the world, so he chooses to scan the thought and the life of two figures seemingly very far from Geography, in order to identify the contribution they, perhaps unaware, have given to this subject. It is like a game of Cultural Geography where the object we want to discover, the geographical character, is to be searched in the events of the life and the works of a great feminist writer and of the father of the modern psychology. For what concerns Simone de Beauvoir, the author explores the extraordinary taste of experimenting and telling about the most different human environments (European, American, social, familiar and personal) using a strength and an effectiveness that may result more remarkable than other more detached and less involving geographical descriptions. On the other side, Sigmund Freud is praised for his capability to recognize how much of the external landscapes perceived by everyone is due to the internal landscapes, developed during the childhood, or anyway, heritage and unsuppressible cognitive lens. These contributions are a treasure not only for Literature and Psychology but for the knowledge and the representation of the whole reality: they deserve, therefore the definition of geographic heritage
A Scalable Cryo-CMOS 2-to-20GHz Digitally Intensive Controller for 4×32 Frequency Multiplexed Spin Qubits/Transmons in 22nm FinFET Technology for Quantum Computers
No full textQuantum computers (QC), comprising qubits and a classical controller, can provide exponential speed-up in solving certain problems. Among solid-state qubits, transmons and spin-qubits are the most promising, operating « 1K. A qubit can be implemented in a physical system with two distinct energy levels representing the |0) and |1) states, e.g. the up and down spin states of an electron. The qubit states can be manipulated with microwave pulses, whose frequency f matches the energy level spacing E = hf (Fig. 19.1.1). For transmons, f 6GHz, for spin qubits f20GHz, with the desire to lower it in the future. Qubit operations can be represented as rotations in the Bloch sphere. The rotation axis is set by the phase of the microwave signal relative to the qubit phase, which must be tracked for coherent operations. The pulse amplitude and duration determine the rotation angle. A π-rotation is typically obtained using a 50ns Gaussian pulse for transmons and a 500ns rectangular pulse for spin qubits with powers of -60dBm and -45dBm, respectively.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.OLD QCD/Charbon LabQCD/Vandersypen LabQCD/Scappucci LabQCD/Veldhorst LabQN/Vandersypen LabElectronics(OLD)Applied Quantum Architecture
CMOS-based cryogenic control of silicon quantum circuits
No full textThe most promising quantum algorithms require quantum processors that host millions of quantum bits when targeting practical applications1. A key challenge towards large-scale quantum computation is the interconnect complexity. In current solid-state qubit implementations, an important interconnect bottleneck appears between the quantum chip in a dilution refrigerator and the room-temperature electronics. Advanced lithography supports the fabrication of both control electronics and qubits in silicon using technology compatible with complementary metal oxide semiconductors (CMOS)2. When the electronics are designed to operate at cryogenic temperatures, they can ultimately be integrated with the qubits on the same die or package, overcoming the ‘wiring bottleneck’3–6. Here we report a cryogenic CMOS control chip operating at 3 kelvin, which outputs tailored microwave bursts to drive silicon quantum bits cooled to 20 millikelvin. We first benchmark the control chip and find an electrical performance consistent with qubit operations of 99.99 per cent fidelity, assuming ideal qubits. Next, we use it to coherently control actual qubits encoded in the spin of single electrons confined in silicon quantum dots7–9 and find that the cryogenic control chip achieves the same fidelity as commercial instruments at room temperature. Furthermore, we demonstrate the capabilities of the control chip by programming a number of benchmarking protocols, as well as the Deutsch–Josza algorithm10, on a two-qubit quantum processor. These results open up the way towards a fully integrated, scalable silicon-based quantum computer.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QCD/Vandersypen LabQCD/Sebastiano LabQuantum & Computer EngineeringQCD/Scappucci LabBUS/TNO STAFFQCD/Veldhorst LabQuantum Circuit Architectures and TechnologyElectronicsQN/Vandersypen La
Restiamo umani. Diventare umanità
No full textIl volume prende le forme a partire dal progetto di Public Engagement 2019 dell’Università di Bergamo dal titolo 'Restiamo umani: riflessioni, pratiche e suggestioni per una comunità che accoglie'. In particolare, raccoglie testi e fotografie relativi a due eventi, realizzati appena prima dell’avvio dell’emergenza pandemica e nella ‘pausa’ tra seconda e terza ondata.
Nel primo, in un incontro appassionato fra eros e logos, Alessandro Sipolo si è esibito con la sua band in un concerto (13 febbraio 2020). Il secondo evento - realizzato il 23 settembre - ha visto la rappresentazione della nostra performance teatrale Resti. Storie siriane, seguita da un dialogo fra l’autrice del testo Elena Corna e Elena Agosti. Nel volume sono riportati gli atti delle due serate, gli stimolanti interventi degli ospiti e la riflessione che li ha accompagnati, insieme a molte immagini. Il tempo passato dalla progettazione alla pubblicazione e l’analisi dei materiali, ha generato la convinzione che siamo chiamat* ad andare oltre l’idea del “restare uman*” per rispondere alla necessità di “diventare umanità”, abbracciando nuovi paradigmi e più innovativi approcci.The book illustrates the Public Engagement 2019 project of the University of Bergamo entitled ‘Restiamo umani: riflessioni, pratiche e suggestioni per una comunità che accoglie’. Specifically, it collects texts and photographs related to two events, realized just before the start of the pandemic emergency and in the short ‘pause’ between the second and third wave. In the first one, in a passionate encounter between eros and logos, Alessandro Sipolo performed with his band in a concert (February 13rd, 2020). The second event - carried out on September 23rd - was the performance ‘Resti. Storie siriane’, followed by a dialogue between the author of the text, Elena Corna, and Elena Agosti. The book contains the proceedings of the two events, the stimulating interventions of the guests along with many images. The time between the planning of the publication and the analysis of the materials has generated the conviction that we have to go beyond the idea of ‘remaining human’ to respond to the need to ‘become humanity’, embracing new paradigms and more innovative approache
