1,721,295 research outputs found
The human salivary proteome and peptidome characterized by a gel-free integrated top-down and bottom-up approach
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Comparison between in vivo and in vitro metabolite production of Morus nigra
No full textNine flavonoids and seven Diels-Alder type adducts were isolated from the acetonic extract of Morus nigra L. root bark, and three flavonoids and six Diels-Alder type adducts were isolated from the acetonic extract of M. nigra L. callus. However, none of the metabolites isolated from the root bark was found in the cell culture. Moreover, adducts isolated from the plant and cell culture showed not only a different cyclohexene ring substitution but also a different stereochemistry, that was found cis-trans in the metabolites isolated from callus, and trans-trans in those isolated from the root bark
On the alkaloids of two African Strychnos, Strychnos nigritana Bak and Strychnos barteri Sol. Carbon-13 NMR spectroscopy of nigritanins
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Facts and artifacts in proteomics of body fluids. What proteomics of saliva is telling us?
No full textThis review briefly depicts several salient points of the current status of knowledge on salivary peptidoma. It outlines the intrinsic difficulties in its characterization connected to different factors of variability, such as: i) the high genetic polymorphisms, complicated by individual insertions/deletions and alternative splicing; ii) complex post-translational maturations comprehending different proteolytic cleavages, glycosylation, phosphorylation and sulfation processes; iii) physiological variations and different contributions to the whole. Moreover, several technological and analytical problems and pitfalls that had to be surmounted during our studies focussed on the extensive qualitative and quantitative characterization of salivary peptidoma and mainly based on LC-MS analyses of intact naturally occurring peptides are here described. The hope is that the information provided might be helpful to other groups engaged on the analysis of saliva or other body fluids for clinical applications
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