1,721,108 research outputs found
Trusted artifact-driven monitoring of business processes using blockchains
No full textHaving a reliable business process monitoring platform is important to promptly detect and react to violations during process execution. Typically, when processes span among multiple organizations or require manual activities, a relationship of trust must be established among participants to obtain meaningful results. Also, when a violation is detected, most monitoring platforms report it and expect participants to stop executing the process and to manually solve it before resuming the execution. Trusted artifact-driven monitoring tries to overcome these limitations. By relying on a declarative model of the process to monitor, rather than an imperative one, trusted artifact-driven monitoring can continue to monitor the process even after a violation occurred. Also, it relies on events coming from artifacts (i.e., physical or virtual objects) participating in the process to infer when activities are executed. Finally, to guarantee the immutability of monitoring information once they are produced, it relies on a blockchain-based architecture to store and retrieve this information
TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders
No full textThe TRIM family comprises proteins characterized by the presence of the tripartite motif composed of a RING domain, one or two B-box domains and a coiled-coil region. The TRIM shared domain structure underscores a common biochemical function as E3 ligase within the ubiquitination cascade. The TRIM proteins represent one of the largest E3 ligase families counting in human more than 70 members. These proteins are implicated in a plethora of cellular processes such as apoptosis, cell cycle regulation, muscular physiology, and innate immune response. Consistently, their alteration results in several pathological conditions emphasizing their medical relevance. Here, the genetic and pathogenetic mechanisms of rare disorders directly caused by mutations in TRIM genes will be reviewed. These diseases fall into different pathological areas, from malformation birth defects due to developmental abnormalities, to neurological disorders and progressive teenage neuromuscular disorders. In many instances, TRIM E3 ligases act on several substrates thus exerting pleiotropic activities: the need of unraveling disease-specific TRIM pathways for a precise targeting therapy avoiding dramatic side effects will be discussed
Artifact-Driven Process Monitoring: A Viable Solution to Continuously and Autonomously Monitor Business Processes
No full textBusiness process monitoring aims at identifying how well running processes are performing with respect to performance measures and objectives. By observing the execution of a process, process monitoring is also responsible for creating process traces, which can be subsequently used by process mining algorithms to gain further insights on the process. Among the various monitoring solutions, artifact-driven monitoring has been proposed as a viable solution to continuously and autonomously monitor business processes. By monitoring the changes in the physical and virtual objects (i.e., artifacts) participating in the process, artifact-driven monitoring can autonomously generate traces that include events related to semi-automatic and manual tasks. Also, by relying on a declarative representation of the process to monitor, artifact-driven monitoring can detecting violations in the execution flow as soon as they occur. In addition, artifact-driven monitoring can identify the process elements affected by a violation, and it can continue monitoring the process without human intervention. This tutorial paper will firstly provide an introduction to process monitoring, and the recent advancements in this field. Then, an overview on how artifact-driven monitoring works will be provided
Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor
No full textCellular Function of TRIM E3 Ubiquitin Ligases in Health and Disease
Full text link: The field of the Tripartite Motif (TRIM) family has progressively attracted increasing interest during the last two decades [...]
Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor
No full textTrusted Artifact-Driven Process Monitoring of Multi-party Business Processes with Blockchain
No full textThe MID1 gene product in physiology and disease
Full text linkMID1 is an E3 ubiquitin ligase of the Tripartite Motif (TRIM) subfamily of RING-containing proteins, hence also known as TRIM18. MID1 is a microtubule-binding protein found in complex with the catalytic subunit of PP2A (PP2Ac) and its regulatory subunit alpha 4 (α4). To date, several substrates and interactors of MID1 have been described, providing evidence for the involvement of MID1 in a plethora of essential biological processes, especially during embryonic development. Mutations in the MID1 gene are responsible of the X-linked form of Opitz syndrome (XLOS), a multiple congenital disease characterised by defects in the development of midline structures during embryogenesis. Here, we review MID1-related physiological mechanisms as well as the pathological implication of the MID1 gene in XLOS and in other clinical conditions
The sulfatase gene family
No full textDuring the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach. These include the gene encoding arylsulfatase E, which is involved in X-linked recessive chondrodysplasia punctata, a disorder of cartilage and bone development. Another important breakthrough has been the discovery of the biochemical basis of multiple sulfatase deficiency, an autosomal recessive disorder characterized by a severe of all sulfatase activities. These discoveries, together with the resolution of the crystallographic structure of sulfatases, have improved our understanding of the function and evolution of this fascinating family of enzymes
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