1,721,034 research outputs found
Response to restless legs syndrome and diabetic neuropathy--commentary by Gemignani, et al
No full textLacosamide for the treatment of epilepsy
No full textIntroduction: Epilepsy is one of the most common neurological disorders. Despite the development of new antiepileptic drugs (AEDs), ∼ 30% of epilepsy patients experience recurrent seizures and even more experience side effects. Therefore, there is still need for new AEDs with enhanced effectiveness and tolerability. Areas covered: The article is based on a search using PubMed, including articles published between 1999 and 2013. It is focused on the pharmacokinetic, pharmacological and clinical data of lacosamide (LCM) for the treatment of epilepsy. Expert opinion: Along with favorable tolerability and pharmacokinetic profiles, LCM has been demonstrated to significantly reduce seizure frequency in patients with partial-onset seizures when prescribed as adjunctive treatment at doses of 200 and 400 mg/day. LCM has a unique mechanism of action, selectively enhancing slow inactivation of voltage-gated sodium channels. Its mechanism of action could be exploited to reduce the percentage of pharmacoresistant patients. Although LCM is not FDA approved for treatment of status epilepticus, it has demonstrated promising preliminary results. Large prospective studies are needed to verify these. In addition, the results of ongoing trials will help to confirm if LCM could be used as a monotherapy regimen in the treatment of partial-onset seizures and generalized tonic-clonic seizures
An integration perspective of security, privacy, and resource efficiency in IoT-Fog networks: A comprehensive survey
No full textThe IoT-Fog paradigm improves delay and network usage because the Fog devices are close to the users. But this closeness causes numerous security and privacy threats. In the research articles, a typical approach is to consider security and resource efficiency separately and assume the other aspect (security or resource efficiency) is working properly. While this perspective is legitimate and routine, in the last few years, researchers have attempted to propose some works that consider them simultaneously. It means that they try to implement their proposed approaches while considering the situation of other aspects. They even propose different approaches for security, privacy, and resource efficiency and test them using metrics specific to each aspect. The integration perspective optimizes resource utilization and minimizes security breaches. To our knowledge, this article is the first survey to examine articles from an integration perspective. This article aims to discuss future research efforts in developing integrated IoT-Fog solutions. It studies the perspective of an aggregated view and discusses the necessities that motivate researchers to integrate them in IoT-Fog networks. The paper examines the IoT-Fog architecture and its associated issues, providing examples of promising applications and usage. The paper groups the studies focusing on security, privacy, and resource efficiency into architectural frameworks, routing protocols, and resource management systems. It explains why these areas are important and why combining them is needed. Finally, the paper suggests some future research topics in this field
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Virtualization and migration at the network edge: An overview
No full textAs for the Cloud, essential features of Fog Computing are both virtualization and the capability to migrate virtual environments among nodes. In this paper, we thoroughly report both the state-of-The-Art virtualization and migration techniques and their available implementations. In particular, we investigate the aptness of such technologies for a specific layer of the Fog hierarchy, namely the network edge. Indeed, this layer presents some characteristics that distinguish it from the Cloud so that a virtualization or migration technique that represents a good compromise for the Cloud might not be likewise suitable for the edge
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
- …
