1,721,068 research outputs found
Ellis, Merlin S.
No full textPhotograph from the C.R. Savage Portrait Studio. Name associated with the photograph: Merlin S. Elli
Escape or Fight: Inhibitors in Hemophilia A
No full textReplacement therapy with coagulation factor VIII (FVIII) represents the current clinical treatment for patients affected by hemophilia A (HA). This treatment while effective is, however, hampered by the formation of antibodies which inhibit the activity of infused FVIII in up to 30% of treated patients. Immune tolerance induction (ITI) protocols, which envisage frequent infusions of high doses of FVIII to confront this side effect, dramatically increase the already high costs associated to a patient's therapy and are not always effective in all treated patients. Therefore, there are clear unmet needs that must be addressed in order to improve the outcome of these treatments for HA patients. Taking advantage of preclinical mouse models of hemophilia, several strategies have been proposed in recent years to prevent inhibitor formation and eradicate the pre-existing immunity to FVIII inhibitor positive patients. Herein, we will review some of the most promising strategies developed to avoid and eradicate inhibitors, including the use of immunomodulatory drugs or molecules, oral or transplacental delivery as well as cell and gene therapy approaches. The goal is to improve and potentiate the current ITI protocols and eventually make them obsolete
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Resource Management in IEEE 802.11 Multiple Access Networks with Price-based Service Provisioning
No full textIn this paper we analyze the provisioning of multimedia services over a wireless LAN hot-spot, based on the IEEE 802.11 protocol. We address the issue of defining proper pricing strategies, from the perspective of both evaluating the technical performance and quantifying the economic revenues. We take into account a model for users' behavior that describes all users' choices in a decentralized manner, so that the transmission rate of each node is driven both by multimedia service requirements and by the customer's willingness to pay. The multiple users' medium access mechanism is studied through a simulation analysis based on ns-2. Within this model, the network performance is evaluated and discussed, presenting numerical results which can provide practical insight for pricing setup in a wireless LAN hot-spot. We observe that the impact of the pricing policy on the provider's income and on the satisfaction of the users is critical and especially depends on the shape of the pricing function (flat, linear or hybrid). Additionally, we investigate the provider's task of having a suitable price policy which properly tunes the tradeoff between the two contrasting factors of achieving high revenue and obtaining high satisfaction of the users
Mathematical Analysis of the Packet Delay Statistics in Bluetooth Piconets under Round Robin Polling Regime
Full text linkPersonal Area Network technologies like Bluetooth and its subsequent derivations and evolutions (Bluetooth v1.2, v2.0+EDR) are valid candidates to realize the mobile and pervasive communication paradigm that is considered in several recent research projects. Although the delay performance of the basic Bluetooth network configuration (piconet) has been widely evaluated through numerical simulations, no satisfactory analytical framework has been yet proposed in the literature. In this paper we present an analysis of the packet delay statistic in Bluetooth piconets, for a limited–1 (round robin) polling strategy. The mathematical model proposed in this paper extends the other models presented in the literature by providing more accurate results for a wider range of traffic patterns, under the assumption of a marked Poisson arrival process. Our analysis provides a complete statistical characterization of the packet delay, by means of Laplace-Stieltjes transform, for generic traffic patterns. Furthermore, expressions for the estimation of the average packet delay for unbalanced and asymmetric traffic are derived, thus improving existing results based on the theory of M/G/1 queues with vacations. Such expressions are, however, rather complex. Therefore, we propose an approximation, based on a renewal argument, which leads to a closed–form expression for the access delay statistic. The proposed analysis permits an accurate estimation of the packet delay under a wide range of network load conditions
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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