1,721,031 research outputs found
Cosmetologia cinese: un viaggio tra tradizioni, arte e tecnologie ereditate dalle grandi dinastie (parte 2)
No full textProsegue l’affascinante viaggio storico attraverso i secoli e le diverse dinastie che hanno governato l’antica Cina, alla scoperta dell’arte cosmetica di questo grande paese. Possiamo così osservare le diverse tecniche formulative e le materie prime vegetali, animali e minerali impiegate per realizzare ciprie, belletti e fard, rossetti, saponi e profumi, oltre a conoscere i metodi usati dalle donne cinesi per applicarli nella decorazione del viso, con uno sguardo anche alle diverse pratiche di igiene e di estetica
Triterpene, Antioxidant, and Antimicrobial Compounds from Melissa officinalis
Full text linkABSTRACT: Six new triterpenes (1–6) and four known compounds have been isolated from dried stems and leaves of Melissa officinalis.
The known compounds were identified as quadranoside III, salvianic acid A, rosmarinic acid, and luteolin. The structures
of compounds 1–6 were established by analysis of spectroscopic data. Free radical scavenging and antimicrobial activities
of the extracts and of rosmarinic acid, the major component, were evaluated
CHEMICAL INVESTIGATION AND IN VITRO CYTOTOXIC ACTIVITY OF RANDIA DUMETORUM LAMK. BARK
Full text linkβ-Sitosterol, lupeol and daucosterol have been isolated from ethanolic extract of Randia
dumetorum bark. β-Sitosterol, Lupeol and Daucosterol have been isolated for the first time from the
Randia dumetorum. β Sitosterol and Daucosterol were identified by complete interpretation of 1H NMR
and 13C NMR spectra using 2D NMR (HSQC, HMBC, DQF-COSY) experiments and Lupeol by direct
comparison with authentic sample. The ethanolic extract is subjected to cytotoxic activity against A549
cell (adenocarcinomic human alveolar basal epithelial cells), BE (2) C (Neuroblastonoma Cell Line), Hela,
MDA-MB-231 (breast cancer cell line), SK MEL-2 (Human Skin Melanoma Cell) and U87MG cell
(Human Neuronale Gliblostoma astrozytom Cell Line) which showed most effective cytotoxic activity at
400 μg/mL concentration on MDA-MB-231 (Breast Cancer Cell Line)
Isolation and in vitro cytotoxic activity of 11-methylixoside isolated from bark of Randia dumetorum Lamk.
Full text linkSaponins and Polyphenols from Fadogia ancylantha (Makoni Tea)
No full textABSTRACT: Three new saponins (1-3) and a known saponin, together with four known polyphenolic compounds, have been isolated
from the fermented and dried leaves of Fadogia ancylantha (Makoni tea). The structures of compounds 1-3 were established by analysis of their spectroscopic data. Both an ethanol-water extract of F. ancylantha and its phenolic constituents showed significant free-radical-scavenging and antimicrobial activities. No cytotoxicity, as evaluated by analysis of hypodiploid nuclei in HUVEC cells using propidium iodide staining, was observed for either the plant crude extract or its constituents
Piroxicam loaded alginate beads obtained by prilling/microwave tandem technique: Morphology and drug release
No full textAbstract: This paper present a tandem technique, based on the combination of prilling and microwave (MW) assisted treatments, to produce biodegradable alginate carriers of piroxicam with different drug controlled release behaviour. Results showed that alginate/piroxicam beads demonstrated high encapsulation efficiency and very narrow dimensional distribution. Beads dried by MW retained shape and size distribution of the hydrated particles while drying rate was strongly increased compared to convective drying processes. Moreover, different MW irradiation regimes promoted interactions between the drug and alginate matrix, affected drug polymorphism as well as inner and surface matrix structure leading to different piroxicam release profiles. High level MW irradiation led to beads with highly porous and swellable matrix able to release piroxicam in few minutes in the intestine while convective drying produced gastro-resistant beads that exhibit sustained piroxicam release (total release in 5.5 hours) in intestinal environment. On these results the tandem technique prilling/MW irradiation appears to be promising to obtain alginate carrier with tailored NSAIDs release depending on drug characteristics and MW irradiation
Novel co-axial prilling technique for the development of core–shell particles as delayed drug delivery systems
No full textIn this study, biocompatible double layered beads consisting of pectin core and alginate shell were prepared through a single step manufacturing process based on prilling apparatus equipped with co-axial nozzles. The core was loaded with piroxicam (PRX) as model non-steroidal anti-inflammatory drug (NSAID). Morphology, size distribution and shape of the double layered beads varied depending on the operative conditions and polymer concentrations. Co-axial nozzles size, applied vibration frequency, gelling conditions and, mainly, polymers mass ratio were identified as critical variables. Particularly, the relative viscosity of polymeric feed solutions inside the nozzle was the key parameter to obtain homogeneous and well-formed coated particles. The produced beads were investigated for the release kinetic in different media. Once PRX was encapsulated within the pectin core, a controlled release pattern was observed. Particularly, beads produced with 4:1 core/shell ratio (F4) released less than 30% of PRX in simulated gastric fluid (SGF) while total liberation of the drug was achieved during the next 3h in simulated intestinal fluid (SIF). More interesting, F4 tested in SIF was able to release drug in a delayed and sustained manner at established time points (2h_8.2%, 3h_32.2%, 4h_70.1% and 5h_about 100%). Based on the above results, co-axial prilling approach is expected to provide success in manufacturing systems with delayed drug release profiles. Such systems may be potentially useful in targeting diseases which are affected by the circadian rhythm, such as chronic inflammation
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