1,721,067 research outputs found
Improvements of RELAP5/Mod3.3 heat transfer capabilities for simulation of in-pool passive power removal systems
Get PDFDespite system thermal–hydraulic codes were extensively validated for transient simulations of LWR, several activities highlighted limited capabilities of these tools to model heat transfer within in-pool passive power removal system. Discrepancies with experimental results were related to the underestimate of pool boiling and film condensation heat transfer coefficients. Thus, the DIAEE of “Sapienza” University of Rome developed a modified version of RELAP5/Mod3.3, able to handle fundamental heat exchange phenomena involved in passive in-pool safety systems. A primary validation procedure has been performed for separated and integral effects. Dealing with nucleate boiling, the Root Mean Squared Relative Error (RMSRE) of wall superheat has been reduced from 1.290 to 0.182. Concerning film condensation, wall temperature RMSRE has been reduced from 0.192 to 0.058. The integral effect assessment has involved an experimental test of the PERSEO facility. The qualitative comparison between experiments and calculations has highlighted significant improvements of the modified RELAP5/Mod3.3
Antigeni solubili di classe I classici e non classici (sHLA G) nei fluidi cerebrospinali della sclerosi multipla
No full textCan a Simulated Flood Experience Improve Social Resilience to Disasters?
No full textThe increase of extreme meteorological phenomena, along with continuous population growth, has led to a rising number of flooding disasters. Therefore, there is an urgent need to develop better risk reduction strategies, among which is increased social resilience. Experiencing a disaster is recognized as a factor that positively influences overall community resilience, with particular effects on social resilience; it appears to be more influential than school education. It also has many negative effects, though. Previous studies underline that citizens do not distinguish between different types of experiences. Thus, we investigated whether a simulated experience of a flood can improve social resilience, without being hampered by negative repercussions. The study was executed in five municipalities in three Italian regions involved in the European project LIFE PRIMES, which planned simulation activities for each studied area. Data, collected through the administration of anonymous questionnaires before and after a flood drill, were processed by applying a multicriteria decision analysis tool (PROMETHEE). Results show that the drill significantly augmented perceived social resilience in the smaller studied communities but not in the larger ones, a fact that should be further investigated. Key Words: multicriteria decision analysis, simulated flood experience, social resilience to disasters
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
HLA-G expression is a fundamental prerequisite to pregnancy
No full textHLA-G antigens are thought to play a key role in implantation by controlling trophoblasts invasion and maintaining a local immunosuppressive state. The secretion of soluble HLA-G antigens (sHLA-G) by early embryos seems necessary for a successful implantation and could be a marker of increased pregnancy rate following in vitro fertilization. We have reviewed the results obtained during the last years. They overall confirmed the predictive role of sHLA-G production in pregnancy outcome. Furthermore, we have examined the technical procedures utilized with a particular attention to the monoclonal antibodies employed in the ELISA techniques.
New functional roles for HLA-G molecules in pregnancy could be suggested by the relationship observed between the presence of sHLA-G antigens in follicular fluids and sHLA-G expression in the corresponding fertilized oocyte. Furthermore, since maternal mRNA is fundamental for proteins production in early embryos, the biological role of the HLA-G 14bp polymorphism could be explored
HLA-G and inflammatory diseases.
No full textHLA-G antigens are non classical HLA-class I molecules characterized by a low allelic polymorphism, a limited tissue distribution and the presence of membrane bound and soluble isoforms. The HLA-G antigens were firstly detected in cytotrophoblast cells at the feto-maternal interface where they maintain a tolerogenic status between the mother and the semiallogenic fetus. Recently a variable expression of HLA-G molecules has been documented in several autoimmune diseases, viral infections, cancer diseases and transplantation. Overall the presence of HLA-G molecules in both membranes bound and soluble isoforms was associated with tolerogenic functions against innate and adaptative cellular responses. HLA-G antigens are able to affect the cytotoxicity of natural killer and CD8+ T cells, CD4+ T lymphocyte functions and dendritic cell maturation. In addition to the allelic polymorphism the HLA-G gene shows a deletion/insertion polymorphism of a 14 base pairs sequence (14bp) in the exon 8 at the 3’ untranslated region. Several reports have associated the presence of the 14bp insertion allele (+14bp) to an unstable mRNA and a lower sHLA-G protein production, suggesting a different ability to counteract inflammation between genotypes. We reviewed the literature on the expression of HLA-G antigens in autoimmune and allergic diseases and the possible functional role of these molecules in counteracting inflammation
Comment on "Experimental extracorporeal photopheresis inhibits the sensitization and effector phases of contact hypersensitivity via two mechanisms: Generation of IL-10 and induction of regulatory T cells"
No full textLetter to the Editor on the paper by paper by Maeda and
coauthors (Experimental Extracorporeal Photopheresis Inhibits the Sensitization and Effector Phases of Contact Hypersensitivity via Two Mechanisms: Generation of IL-10 and Induction of Regulatory T Cells. J Immunol 2008; 181:5956-5962
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