1,721,129 research outputs found
MdMD excursions along the pathway of the UBL domain across Parkin.
No full text<p>Representative pathways via MdMD excursions between LC-MOD/MC generated conformers for the movement of the N-terminal region (residues 1–140) in MDS state 1 (panel <b>A</b>) to the active site region in MDS state 5 (panel <b>E</b>). Panels <b>A–E</b> and <b>A′–E′</b> represent the five key points from the guideposts that MdMD was able to drive the structures toward. RMSD between the structural model and the guideposts were within 3 Å in each case. Color-coded ribbon structures are given. <b>A</b>) The initial structure for Parkin is mostly unperturbed after 3 ns of MdMD sampling with global variable based on LCMOD sampling between generated Parkin conformers. <b>B</b>) Opening of the N-terminal region is shown after>10 ns of MdMD sampling. <b>C</b>) Midpoint for the UBL domain movement towards the active site region following>15 ns of MdMD sampling. The linker helix region is more dynamic, exposing the E2 binding site in RING1. <b>D</b>) UBL domain adjustment as it approaches the C-terminal region after 30 ns of MdMD sampling. <b>E</b>) The UBL domain is in final position and occupies region around the active site (Cys431) after 35 ns of MdMD sampling. <b>A′–E′</b>) Superposition of the four replicates from MdMD that match the relative time point/stage from panels <b>A–E</b>. Ensemble of structures from replicates gives a common relative pathway between guideposts generated conformers.</p
Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22
No full textAcross species, animals have diverse sex determination pathways, each consisting of a hierarchical cascade of genes and its associated regulatory mechanism. Houseflies have a distinctive polymorphic sex determination system in which a dominant male determiner, the M-factor, can reside on any of the chromosomes. We identified a gene, Musca domesticamale determiner (Mdmd), as the M-factor. Mdmd originated from a duplication of the spliceosomal factor gene CWC22 (nucampholin). Targeted Mdmd disruption results in complete sex reversal to fertile females because of a shift from male to female expression of the downstream genes transformer and doublesex The presence of Mdmd on different chromosomes indicates that Mdmd translocated to different genomic sites. Thus, an instructive signal in sex determination can arise by duplication and neofunctionalization of an essential splicing regulator
Singular value spectra for Jacobian matrix of HD-DOT, MDMD, Arrangement-1 and 2.
No full textSingular value spectra for Jacobian matrix of HD-DOT, MDMD, Arrangement-1 and 2.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Indicates the similarity of all reconstructed and synthetic hemodynamic in S1-S9 region for HD-DOT, Arrangement-1, Arrangement-2 and MDMD.
No full textIndicates the similarity of all reconstructed and synthetic hemodynamic in S1-S9 region for HD-DOT, Arrangement-1, Arrangement-2 and MDMD.</p
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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