75 research outputs found
Il postillato autografo delle Prose della volgar lingua: primi appunti
No full textIl saggio annuncia il ritrovamento di una copia finora sconosciuta della prima edizione delle Prose della Volgar lingua (Venezia, Tacuino, 1525), che contiene numerose notazioni autografe di Pietro Bembo. Le postille sono utili per compremderevla storia editoriale del testo e i mutamenti attuati dall’autore nella seconda e nella terza edizione (Venezia, Marcolini, 1539 and Firenze, Torrentino, 1549), come pure per una ricostruzione delle scelte linguistiche di Bembo e per la messa a fuoco di alcune sue fonti, ancora non identificate. The essay announces the identification of an unknown copy of the first edition of the Prose della volgar lingua (Venezia, Tacuino, 1525) which bears numerous autograph annotations by Bembo in its margins. His notes enable us to reconstruct the editorial history of the text and the changes made by its author in the second and third editions (Venezia, Marcolini, 1539 and Firenze, Torrentino, 1549), as well as detailing Bembo’s reasoning on some linguistic issues and revealing references to various sources, hitherto unidentified
Il postillato autografo delle Prose della volgar lingua: primi appunti
No full textIl saggio annuncia il ritrovamento di una copia finora sconosciuta della prima edizione delle Prose della Volgar lingua (Venezia, Tacuino, 1525), che contiene numerose notazioni autografe di Pietro Bembo. Le postille sono utili per compremderevla storia editoriale del testo e i mutamenti attuati dall'autore nella seconda e nella terza edizione (Venezia, Marcolini, 1539 and Firenze, Torrentino, 1549), come pure per una ricostruzione delle scelte linguistiche di Bembo e per la messa a fuoco di alcune sue fonti, ancora non identificate.The essay announces the identification of an unknown copy of the first edition of the Prose della volgar lingua (Venezia, Tacuino, 1525) which bears numerous autograph annotations by Bembo in its margins. His notes enable us to reconstruct the editorial history of the text and the changes made by its author in the second and third editions (Venezia, Marcolini, 1539 and Firenze, Torrentino, 1549), as well as detailing Bembo’s reasoning on some linguistic issues and revealing references to various sources, hitherto unidentified
Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT
No full textTo date, PROPELLER MRI, a breathing-motion-insensitive technique, has not been assessed for cystic fibrosis (CF) lung disease. We compared this technique to CT for assessing CF lung disease in children and adults. Thirty-eight stable CF patients (median 21 years, range 6-51 years, 22 female) underwent MRI and CT on the same day. Study protocol included respiratory-triggered PROPELLER MRI and volumetric CT end-inspiratory and -expiratory acquisitions. Two observers scored the images using the CF-MRI and CF-CT systems. Scores were compared with intra-class correlation coefficient (ICC) and Bland-Altman plots. The sensitivity and specificity of MRI versus CT were calculated. MRI sensitivity for detecting severe CF bronchiectasis was 0.33 (CI 0.09-0.57), while specificity was 100 % (CI 0.88-1). ICCs for bronchiectasis and trapped air were as follows: MRI-bronchiectasis (0.79); CT-bronchiectasis (0.85); MRI-trapped air (0.51); CT-trapped air (0.87). Bland-Altman plots showed an MRI tendency to overestimate the severity of bronchiectasis in mild CF disease and underestimate bronchiectasis in severe disease. Motion correction in PROPELLER MRI does not improve assessment of CF lung disease compared to CT. However, the good inter- and intra-observer agreement and the high specificity suggest that MRI might play a role in the short-term follow-up of CF lung disease (i.e. pulmonary exacerbations). aEuro cent PROPELLER MRI does not match CT sensitivity to assess CF lung disease. aEuro cent PROPELLER MRI has lower sensitivity than CT to detect severe bronchiectasis. aEuro cent PROPELLER MRI has good to very good intra- and inter-observer variability. aEuro cent PROPELLER MRI can be used for short-term follow-up studies in CF
Artrite reumatóide: diagnóstico e tratamento
No full textDESCRIÇÃO DO MÉTODO DE COLETA DE EVIDÊNCIAS: Reunião consensual e multidisciplinar com a participação de médicos reumatologistas, fisiatra e ortopedista para elaboração do texto final. O texto inicial tomou por base o documento do Colégio Americano de Reumatologia "Guidelines for the management of rheumatoid arthritis" e também o texto das "Diretrizes do Ministério da Saúde para o Diagnóstico e Tratamento da Artrite Reumatóide", acrescido da experiência de reumatologistas, e complementado por extensa revisão bibliográfica, com prioridade para meta-análises. Os participantes, divididos em três grupos, produziram o texto básico, cujas recomendações foram submetidas à revisão e à aprovação pelo conjunto dos participantes. Depois, disponibilizados na internet, foi objeto de novas sugestões por parte de outros especialistas, até alcançar a forma final. GRAU DE RECOMENDAÇÃO E FORÇA DE EVIDÊNCIA: A: Estudos experimentais e observacionais de melhor consistência. B: Estudos experimentais e observacionais de menor consistência. C: Relatos de casos (estudos não controlados). D: Opinião desprovida de avaliação crítica, baseada em consensos, estudos fisiológicos ou modelos animais. OBJETIVOS: Estabelecer diretrizes claras e sucintas para o diagnóstico e tratamento da artrite reumatóide. CONFLITO DE INTERESSE: Os autores Laurindo IMM, Ximenes AC, Lima FAC, Pinheiro GRC, Bertolo MB, Xavier RM, Ciconelli RM e Radominski SC declararam vínculo com a Indústria Farmacêutica
Depressive symptoms in rheumatoid arthritis patients
No full textFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Objective To determine the prevalence of depressive and anxiety symptoms in patients with rheumatoid arthritis (a chronic inflammatory disease) in comparison to a control group with osteoarthritis (a chronic non inflammatory degenerative disease) and to identify the sociodemographic and clinical variables associated with depressive symptoms in these patients Method Sixty-two rheumatoid arthritis patients and 60 osteoarthritis patients participated in the study Sociodemographic and clinical data were collected and the Hospital Anxiety and Depression Scale and the Disability Index of the Health Assessment Questionnaire were applied Results The prevalence of depressive symptoms was of 53 2% in rheumatoid arthritis and 28 3% in osteoarthritis (p = 0 005) The prevalence of anxiety symptoms was of 48 4% in rheumatoid arthritis and 50 0% in osteoarthritis (p = 0 859) The mean (and standard deviation) scores in the Disability Index of the Health Assessment Questionnaire were 1 4 (0 8) in rheumatoid arthritis and I 4 (0 6) in osteoarthritis (p = 0 864) Rheumatoid arthritis patients with depressive symptoms had lower education and higher disease activity and functional disability Conclusion Although these two rheumatic diseases are similar in terms of the pain and functional disability that they cause a significantly higher prevalence of depressive symptoms was found in rheumatoid arthritis patients This difference might be explained by the hypothesis of a neuroimmunobiological mechanism related to cytokines in inflammatory disease, which has been considered as a candidate to the development of depressive symptoms323257263Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq
FRI0094 The applicability of the american college of rheumatology nomenclature and case definition for neuropsychiatric lupus syndromes. analysis of 527 patients
No full textSchistosoma mansoni infection: an immune complex disease presenting with polyarthritis
No full textFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Schistosomiasis or bilharzia is a parasitic disease found in tropical countries. Most infections are subclinical but may progress to chronic form characterized most frequently by the presence of liver involvement and portal hypertension. We report a patient that presented chronic polyarthritis with positive rheumatoid factor. During investigation, increased liver enzymes, negative hepatitis serologies and signs of portal hypertension on an ultrasound examination raised suspicion of S. mansoni infection. We will discuss pathophysiology and clinical manifestations of S. mansoni infection with special attention to articular involvement.33513411343Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP [2009/16785-1, 2008/02917-0, 2009/06049-6]CNPq [300447/2009-4
Cleavage Fracture Micromechanisms of High Strength Steel and its Heat-Affected Zones
No full textThe use of materials in increasingly severe service conditions raises concerns about structural safety with respect to cleavage fracture. There are three main material-related challenges that structures face under harsh environments: 1) the trade-off between strength and toughness; 2) the ductile-to-brittle transition behaviour of BCC high strength steels; 3) the inhomogeneous microstructures found in multiphase steels, thick-section steels, and welded structures. Therefore, the objective of this research is to systematically investigate the cleavage fracture micromechanisms in high strength steels considering diverse microstructures (e.g., as-received commercial steel, thermally simulated heat-affected zones, and grain refined microstructure) and experimental conditions (e.g., plastic constraint and temperature). Thereby, this study provides a thorough understanding of the effect of the microstructural details on cleavage fracture behaviour of high strength steel structures allowing for failure control and improvement of cleavage-resistant steel’s design..
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