188,792 research outputs found
MAZZONE P. & G. PELLIZZARI - 1991 - Effetti collaterali di fitofarmaci su artropodi utili.
No full textMAZZONE P. & G. PELLIZZARI - 1991 - Effetti collaterali di fitofarmaci su artropodi utili.
No full textMulti-target strategy for Parkinsonian patients: the role of deep brain stimulation in the centromedian-parafascicularis complex.
No full textBrain Res Bull. 2009 Feb 16;78(2-3):113-8. doi: 10.1016/j.brainresbull.2008.08.007. Epub 2008 Sep 21.
Multi-target strategy for Parkinsonian patients: the role of deep brain stimulation in the centromedian-parafascicularis complex.
Stefani A, Peppe A, Pierantozzi M, Galati S, Moschella V, Stanzione P, Mazzone P.
SourceIRCCS Fondazione S. Lucia, Roma, Italy. [email protected]
Abstract
The intra-laminar (IL) thalamic complex, composed of centromedian (CM) and parafascicular (Pf) nucleus, is a strategic crossroad for the activity of the basal ganglia and is recently regaining its position has a putative neurosurgical target for Parkinsonian syndromes. The multi-target approach we have encouraged since the late nineties has allowed the combined implantation of a standard target (the subthalamic nucleus-STN or the internal pallidus-GPi) plus an innovative one (CM/Pf) in well-identified Parkinson's disease (PD) patients; hence, it is possible to study, in the same PD patients, the specific target-mediated effects on different clinical signs. Here, we focus on the potential usefulness of implanting the CM/Pf complex when required in the management of contra-lateral tremor (resistant to standard deep brain stimulation-DBS - in STN - , n=2) and disabling involuntary movements, partially responsive to GPi-DBS (n=6). When considering global UPDRS scores, CM/Pf-DBS ameliorate extra-pyramidal symptoms but not as strongly as STN (or GPi) does. Yet, CM/Pf acts very powerfully on tremor and contributes to the long-term management of l-Dopa-induced involuntary movements. The lack of cognitive deficits and psychic impairment associated with the improvement of their quality of life, in our small cohort of CM/Pf implanted patients, reinforces the notion of CM/Pf as a safe and attractive area for surgical treatment of advanced PD, possibly affecting not only motor but also associative functions
[Mario and Mazzone (c.1947), funerary sculpture]
No full textFrom Berresford: Mario and Mazzone (c.1947), F.Vannuci, Cimitero delle Porte Sante, Florence.Woman in gown, man in military uniform.Title from Berresford
Conceptual and methodological challenges for neuroimaging studies of autistic spectrum disorders
No full textAbstract Autistic Spectrum Disorders (ASDs) are a set of complex developmental disabilities defined by impairment in social interaction and communication, as well as by restricted interests or repetitive behaviors. Neuroimaging studies have substantially advanced our understanding of the neural mechanisms that underlie the core symptoms of ASDs. Nevertheless, a number of challenges still remain in the application of neuroimaging techniques to the study of ASDs. We review three major conceptual and methodological challenges that complicate the interpretation of findings from neuroimaging studies in ASDs, and that future imaging studies should address through improved designs. These include: (1) identification and implementation of tasks that more specifically target the neural processes of interest, while avoiding the confusion that the symptoms of ASD may impose on both the performance of the task and the detection of brain activations; (2) the inconsistency that disease heterogeneity in persons with ASD can generate on research findings, particularly heterogeneity of symptoms, symptom severity, differences in IQ, total brain volume, and psychiatric comorbidity; and (3) the problems with interpretation of findings from cross-sectional studies of persons with ASD across differing age groups. Failure to address these challenges will continue to hinder our ability to distinguish findings that outline the causes of ASDs from brain processes that represent downstream or compensatory responses to the presence of the disease. Here we propose strategies to address these issues: 1) the use of simple and elementary tasks, that are easier to understand for autistic subjects; 2) the scanning of a more homogenous group of persons with ASDs, preferably at younger age; 3) the performance of longitudinal studies, that may provide more straight forward and reliable results. We believe that this would allow for a better understanding of both the central pathogenic processes and the compensatory responses in the brain of persons suffering from ASDs.</p
Progress in deep brain stimulation of the pedunculopontine nucleus and other structures: implications for motor and non-motor disorders
No full text
Further improvements in the structural analysis of DEMO Divertor Cassette body and design assessment according to RCC-MRx
No full textThis paper presents the enhancements related to the structural analyses of DEMO Divertor in the framework of the EUROfusion Power Plant Physics & Technology (PPPT) program. This activity started two years ago and its preliminary results were published in previous papers. It has been divided in some areas defined by the similarity of the matters they contain: the structural analysis, of utmost importance, has been preceded by a preliminary phase, like the geometry definition or the thermal and the electric-magnetic analysis for loads evaluation; then the structural analysis has been finally confirmed with further evaluations related to excessive deformation or plastic instability. This paper discusses the improvements adopted either in the preliminary analysis or in the main structural analysis. Specifically it highlights the introduction of the thermal and electro-magnetic loads application in terms of a detailed spatial distribution that is now available. More the supports have been introduced in the model and their structural behavior has been investigated considering their interaction with the cassette. The structural assessment, according to the Design and Construction Rules for Mechanical Components of Nuclear Installation (RCC-MRx), has been performed either for the cassette or for the attachments: for the former it is positive while for the latter case serious limitations have been found. © 201
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