194 research outputs found
Fine-needle aspiration of cutaneous, subcutaneous, and intracavitary masses in dogs and cats using 22- vs 25-gauge needles
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Subcutaneous Hematoma Elevates Plasma Levels of FDP and D-Dimer; an Analysis by Animal Model Experiments
No full textTakami Nakao,1,* Yasuhide Kitazawa,2,* Shiori Masuda,3 Naoki Hashimoto4 1Critical Care Medical Center, Kindai University Nara Hospital, Ikoma-city, Nara, Japan; 2Department of Emergency Medicine, Izumi City General Medical Center, Izumi-city, Osaka, Japan; 3Department of Clinical Laboratory, Kindai University Nara Hospital, Ikoma-city, Nara, Japan; 4Department of Emergency Medicine, Sanda City Hospital, Sanda-city, Hyogo, Japan*These authors contributed equally to this workCorrespondence: Yasuhide Kitazawa, Department of Emergency Medicine, Izumi City General Medical Center, 4-5-1 Wake-cho, Izumi-city, Osaka, 594-0073, Japan, Tel +81-725-41-1331, Fax +81-725-43-3660, Email [email protected]: Trauma-associated coagulopathy has been considered to develop as a result of increased fibrinolysis due to massive bleeding, tissue damage and hypoperfusion. However, it has not been investigated whether hematoma may cause trauma-associated coagulopathy. Using experimental animal model, we analyzed the effects of hematoma formation on coagulation and fibrinolysis parameters.Materials: Male Wistar rats were used for the studies.Methods: We made an animal model of subcutaneous hematoma without tissue injuries. This model can be categorised as a kind of trauma models. We created experimentally subcutaneous hematomas in test animals using blood collected from other animals. We performed blood sampling to measure blood cell counts and coagulation parameters from test animals at 1, 6, 24, 48 and 96 hours after hematoma generation. Blood samples were collected and immediately sent for measurement of CBC, Prothrombin, FDP, D-dimer, Fibrinogen, Antithrombin, AST and ALT. Furthermore, after 1, 24 and 48 hours, we performed dynamic evaluation of coagulation/fibrinolysis function using thromboelastometry method.Results: After the hematoma were created, FDP and D-dimer increased over time, and reached a plateau after 48 hours. During the period, there was no decrease in Fibrinogen and Antithrombin, and no thrombocytopenia occurred. Moreover, no obvious changes in coagulation/fibrinolysis function were observed employing thromboelastometry.Discussion: Elevated FDP and D-dimer after hematoma creation are assumed to be synthesized in the hematoma, not in the streaming blood. Thromboelastometry also shows that elevated levels of FDP and D-dimer are not caused by intravascular coagulation and subsequent fibrinolysis.Conclusion: The study showed that subcutaneous hematomas caused increases in FDP and D-dimer levels, without activating the blood coagulation/fibrinolysis system.Keywords: trauma, coagulopathy, fibrinolysis, intravascular coagulatio
Antibacterial efficacy of several surgical hand preparation products used by veterinary students: Efficacy of alcohol-based surgical hand preparations
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Japanese parturient body mass index and the role in initial nerve block height of women undergoing cesarean delivery with spinal anesthesia
No full text博士(医学) 甲第733号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Futaba MIYOSHI, Risa FUKUSHIMA, Sumire YOKOKAWA, Shiori SAKUMA, Minoru NOMURA, Hiroyuki KINOSHITA，タイトル:Japanese parturient body mass index and the role in initial nerve block height of women undergoing cesarean delivery with spinal anesthesia，掲載誌:Medicine(0025-7974)，巻・頁・年:99巻23号 p.e20584(2020)，著作権関連情報: © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.，DOI:10.1097/MD.000000000002058
Dōka hyakunin isshu fumoto no shiori 道歌百人一首麓枝折
No full textHand-drawn manuscriptTranslation: One hundred Daoists, one poem, markers on the foot of the hill.Date unknownSize: 4 13/16 x 7 in
Japanese parturient body mass index and the role in initial nerve block height of women undergoing cesarean delivery with spinal anesthesia
No full text東京女子医科大学博士(医学)博士(医学) 甲第733号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Futaba MIYOSHI, Risa FUKUSHIMA, Sumire YOKOKAWA, Shiori SAKUMA, Minoru NOMURA, Hiroyuki KINOSHITA，タイトル:Japanese parturient body mass index and the role in initial nerve block height of women undergoing cesarean delivery with spinal anesthesia，掲載誌:Medicine(0025-7974)，巻・頁・年:99巻23号 p.e20584(2020)，著作権関連情報: © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.，DOI:10.1097/MD.0000000000020584doctoral thesi
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