1,720,989 research outputs found
Histopathological findings in the central nervous system of Montezuma swordtail (Xiphophorus montezumae Jordan & Snyder, 1899) fry with early mortality associated with severe neurological signs
No full textIntroduction: Neurological syndromes in fry may be associated with internal or external hydrocephalus
caused by a variety of injuries, including toxic, nutritional, infectious, and genetic/heritable
factors. However, limited information concerning histopathological features of nervous tissue of fish
with neurological signs is available.
Materials and Methods: A total of 33 live, swim-up fry were produced in an aquarium colony of
the live-bearer Xiphophorus montezumae, composed by 3 females and 1 male. About fifteen days
after birth, fry showed severe neurological signs ranging from anorexia and lethargy to swimming
difficulties, whirling and loss of equilibrium. No gross abnormality was evident. Immediately after
spontaneous death, 31 fry were formalin-fixed and routinely processed for histology. Two fry survived
without clinical signs. Adult fish were not affected.
Results: Histological examination of all affected fry revealed various degrees of external hydrocephalus
characterized by increased space between the meninges and the brain, with presence
of scant protein-like material in the sub-arachnoid space. Variable, usually mild, vacuolation of the
nervous tissue was also observed. Brain was only covered by the skin on the dorsal part of chondrocranium.
Conclusions: This is the first description of neurological disease associated with histological features
of external hydrocephalus in the Montezuma swordtail. Water quality analysis and absence
of pharmacological treatments allowed to exclude toxic causes. Vitamin deficiencies were also unlikely,
since a well-balanced and integrated, commercial diet specific for swim-up fry was provided.
Based upon the lack of evidence for an infectious, especially viral, etiology, a congenital, possibly
genetic, condition may be supposed
Effects of Hsp90 inhibitor 17-AAG on vasculogenic mimicry in D22 and D17 canine osteosarcoma cell lines
No full text
Ovarian teratoma in an adult female Zoogoneticus tequila (Webb & Miller 1998): histological and immunohistochemical features.
No full textImpact of Nutritional Supplementation on Canine Dermatological Disorders
Full text linkNutritional supplements, also known as complementary feeds, are products administered with the aim of furnishing health benefits, regardless of nutritional needs. They have been used since ancient times in veterinary dermatology, and a number of studies have focused on investigating the health benefits of some ingredients found in commercially available complementary feed for dogs. The aim of this paper is to review the literature available on the use of nutritional supplementation for the management of canine skin diseases, critically appraising the clinical efficacy of such interventions and summarizing the current state of knowledge. This review highlights how these feeds can be considered useful in the management of dermatological disorders and outlines their beneficial effects in the prevention of dietary deficiencies and treatment of diseases, alone, or in addition to conventional pharmacological therapy. In recent years, nutritional supplements have found increasing potential application in veterinary medicine, and the scientific proofs of their beneficial effects are described in this review
Strain and Shear-Wave Elastography and Their Relationship to Histopathological Features of Canine Mammary Nodular Lesions
No full textMammary gland tumours have a significant impact on the health of dogs, requiring diagnostic tools to support clinicians to develop appropriate therapeutic strategies. Sonoelastography is an emerging technology that is able to define the stiffness of the tissue and has promising applications in the evaluation of mammary gland lesions. In the present study, strain elastography (STE) and shear-wave (SWE) elastography were compared in 38 mammary nodular lesions for their ability to define the histopathological features of canine mammary lesions. Among the techniques, SWE showed better repeatability (intraclass correlation coefficient: 0.876), whereas STE was found to be only acceptable (intraclass correlation coefficient: 0.456). Mammary nodular lesions showed a wide range of tissue stiffening with a similar mean value for STE and SWE in benign (4 ± 0.3 and 115.4 ± 12.6 kPa, respectively) and malignant lesions (3.8 ± 0.1 and 115.5 ± 4.5 kPa, respectively). A significant correlation was found between lesion fibrosis and STE (STE-I: r = 0.513, p < 0.001; STE-R: r = 0.591, p < 0.001) or SWE-S (r = 0.769; p < 0.001). In conclusion, SWE was reliable and correlated with fibrosis and was similar for both benign and malignant lesions, suggesting that other collateral diagnostic techniques should be considered in conjunction with SWE to characterize mammary nodular lesions in dogs
Concomitant diffuse pulmonary carcinoma and chronic interstitial pneumonia in a cat with hypertrophic cardiomyopathy: unusual pathological findings and differential diagnosis.
No full textIntroduction: Bronchioloalveolar carcinoma (BAC) may occasionally occur in a diffuse form involving
most or all of the lung parenchyma. This form may mimic other, more common diffuse interstitial
lung diseases in both humans and animals.
Materials and Methods: A 12-year-old spayed female European shorthair cat presented with severe
dyspnoea. Echocardiography revealed hypertrophic cardiomyopathy and pleural effusion. The
cat died form acute decompensated heart failure. At necropsy, lungs appeared diffusely congested
and firm, with presence of multifocal to coalescing, irregular grayish areas, and sparse hemorrhages.
Lung tissue samples were routinely processed for histology and immunohistochemistry for
pan-cytokeratin, vimentin, CAM 5.2, MAC387, CD3, Ki-67.
Results: Lung histopathology revealed a diffuse neoplastic proliferation characterized by irregular
alveolar growth with multifocal micropapillary formations. Tumour cells were large, predominantly
cuboidal in shape, with marked nuclear pleomorphism, prominent nucleoli, multifocal binucleated
elements, high Ki-67 proliferative index and intense positivity for pan-cytokeratin and CAM 5.2. Metastases
to tracheobronchial lymph nodes or other organs were not observed. Tumour growth was
obscured by simultaneous lesions related to chronic congestion and interstitial pneumonia, characterized
by numerous, intra-alveolar MAC387+ macrophages with multifocal erytrophagocytosis and
segmental foci of bronchioloalveolar hyperplasia.
Conclusions: Histological tumour pattern characterized by neoplastic cells budding from alveolar
surface was consistent with a diagnosis of diffuse BAC with unusual presence of large, pleomorphic
tumour cells. Differential diagnosis included large cell carcinoma, which is usually characterized by
rosettes or solid clusters of cells occupying alveolar lumen. Extensive cytokeratin immunostaining
was also helpful in the differentiation from histiocytic proliferative diseases
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
