1,721,182 research outputs found
Masi (Antonio). Ricerche sul la res privata del princeps
No full textChevallier R. Masi (Antonio). Ricerche sul la res privata del princeps. In: Revue belge de philologie et d'histoire, tome 52, fasc. 1, 1974. Antiquité - Oudheid. p. 175
Social entrepreneurship implementation in developing countries: pursuing an effective blended value creation
No full textLa tesi è finalizzata a indagare l’efficacia dell’imprenditoria sociale quale strumento di contrasto a situazioni di grave povertà e disagio sociale nei paesi in via di sviluppo. Particolare attenzione è rivolta alle principali sfide derivanti dal molteplice sforzo di promuovere lo sviluppo socio-economico locale, garantire la sostenibilità economica delle iniziative e - talvolta - tutelare l’ambiente naturale.
La prima parte della tesi fornisce un framework teorico sull’imprenditoria sociale, con specifico riferimento ad alcuni aspetti critici della sua stessa essenza, alle sue potenzialità nella lotta alla povertà e ai caratteri distintivi del suo processo di implementazione.
La seconda parte presenta due analisi empiriche sviluppate con il metodo dei casi e afferenti, rispettivamente, gli ambiti del non-profit e del for-profit. La prima esamina i processi di identificazione delle opportunità e di costruzione del business model, al fine di mettere in luce le divergenze esistenti tra le prospettive sociale, economica ed ambientale, e di comprendere come coniugarle; la seconda identifica alcune cruciali variabili - interne ed esterne - che incidono sul processo di implementazione ed implicano la necessità di conciliare finalità, approcci e strumenti tipici degli ambiti filantropico e imprenditoriale, ai fini di una efficace creazione di valore socio-economico.The thesis aims at investigating social entrepreneurship attitude to truly act as a crucial tool in the fight against deep poverty and social disadvantages in developing countries, with a particular focus on the main challenges faced by social entrepreneurial organizations in their attempt to promote local social-economic development, while ensuring their own economic viability, and (sometimes) preserving global environment.
The first part of the thesis provides a theoretical framework about social entrepreneurship landscape, with specific attention to some crucial aspects of its essence, its potentiality against poverty, and some distinctive features of its implementation process.
The second part presents two empirically-based analyses carried out by using case-study method, respectively from the for-profit and the not-for-profit domains. The former investigates the processes of opportunity recognition and business model design, with the aim to highlight the divergences among social, economic, and environmental perspectives, and to understand how to combine them; the latter identifies some crucial - internal and external -variables affecting the implementation process and implying the need for a mix between charitable and business aims, approaches, and tools, for a successful blended value creation
Social Entrepreneurship in Developing Countries: Green Technology Implementation to push local Social and Economic Innovation
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Low-molecular-weight thiols in plants: Functional and analytical implications
No full textLow-molecular-weight (LMW) thiols are a class of highly reactive compounds massively involved in the
maintenance of cellular redox homeostasis. They are implicated in plant responses to almost all stress
factors, as well as in the regulation of cellular metabolism. The most studied LMW thiols are glutathione
and its biosynthetically related compounds (cysteine, c-glutamylcysteine, cysteinylglycine, and
phytochelatins). Other LMW thiols are described in the literature, such as thiocysteine, cysteamine,
homocysteine, lipoic acid, and many species-specific volatile thiols. Here, we review the known LMW
thiols in plants, briefly describing their physico-chemical properties, their relevance in post-translational
protein modification, and recently-developed thiol detection methods. Current research points to a huge
thiol biodiversity in plants and many species-specific and organ-specific thiols remain to be identified.
Recent advances in technology should help researchers in this very challenging task, helping us to
decipher the roles of thiols in plant metabolism
LA MODULAZIONE DEI LIVELLI DI GLUTATIONE COME STRATEGIA DI ATTACCO NELLE INTERAZIONI OSPITE-PARASSITA
Full text linkInsect studies, dealing with parasitism of aphids, have shown that the disruption of host glutathione (GSH) pool and
metabolisms significantly contributes to its physiological regulation and castration. The parasitic wasp Aphidius ervi injects into
host aphids a venom containing large amounts of a gamma-glutamyltransferase (Ae-GGT) enzyme, which causes a depletion of
GSH primarily involving ovarian tissue. Injected Ae-GGT in fact consumes substrate GSH, which ultimately triggers apoptosis.
Studies on virulence factors of microrganisms have documented that the invasion strategies of selected pathogenic bacteria also
target host GSH metabolism. Indeed, it has been shown that GGT activity of Helicobacter pylori and H. suis, the agents responsible
of peptic ulcer, can exert antiproliferative and pro-apoptotic effects in gastric epithelial cells. By confocal microscopy, H. suis outer
membrane vesicles (OMV) − submicroscopic structures 20-50 nm in diameter, budding from the cell surface − were identified as
carriers of H. suis GGT, capable of delivering the enzyme to the deeper mucosal layers. In association with such membranous
structures, active GGT from H. suis in fact translocates across the epithelial layers and can access lymphocytes residing in the
gastric mucosa, resulting in the inhibition of lymphocyte proliferation, i.e., a perturbation of host immunity and a facilitation of
bacterial infection. Cellular GSH appears, thus, to represent a conserved target for parasitic (micro)organisms which aim at altering
host redox homeostasis to weaken its immune defenses, using GGT as a key-element of a virulence strategy. Taking into account
the “parasitic” behavior exhibited by malignant cells spreading across tissues and organs of the patient (the “host”). GGT activity
is in fact expressed in a number of malignant tumors, and expression levels often increase along with progression to more invasive
phenotypes. Now, active GGT can be released from cells, including cancer cells, in association with submicroscopic vesicles resembling
exosomes. The similarity of such structures with GGT-rich OMV particles of H. pylori and H. suis is indeed obvious. GGT
activity of cancer cells can affect intracellular redox equilibrium, and produces in addition significant extracellular effects, e.g. on
the redox status and ligand binding affinity of cell surface receptors related with cell survival/apoptosis balance. Thus, GGT-rich
exosomes shed by cancer cells can produce in host’s surrounding tissues effects comparable to those reported for Ae-GGT or Helicobacter
GGT, possibly resulting in facilitation of malignant cells survival and diffusion
Social enterprise implementation by nonprofits in emerging economies: Facing change management challenges
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