177,049 research outputs found
Signum Vortumni Project. Il palinsesto architettonico a est degli Horrea Agrippiana. Un’analisi preliminare
No full textDuring the archeological excavations of Signum Vortumni Project (2016-2019) in the Horrea Agrippiana area there were being carry out survey and masonries's analysis at ground level of the complex situated at east of augustean warehouses. It deals with an unpublished architectural palimpsest that enriches the topographical framework of the site together with to data of recent excavations, regarding before Agrippa's warehouses. The acquisition and the analysis of those evidences gave back interesting novelties about the presence of a new domus late republican age B.C.) characterized by terraces on north-west low slopes of Palatine with a rich decorative elements. Obviously it belongs to a member of nobilitas senatorial. Those studies reveal that the domus has been disposed by brickwork's structures built befoure Horrea and dated to the first half of I B.C. New buildings, highlight in partial remains, allows to make some further reflections about Agrippa's complex and the making of the first Imperal Palaces on this side of Palatine
Development of a genetic algorithm for covariate analysis in population pharmacokinetic models
No full textAppropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Targeting Cancer Stem Cells: New Perspectives for a Cure to Cancer
No full textCancer stem cells (CSCs) are present in many solid tumors. Their signaling pathways and functions may be the key to developing new anticancer strategies against cancer. Several studies have linked the signaling pathways’ (e.g., Wnt, Notch, and Hedgehog pathways) aberrant activation to the development of numerous cancers. These signaling pathways hence provide attractive targets for further study toward new therapies. CSCs show several characteristics, such as self-renewal, differentiation, high tumorigenicity, and resistance to anticancer drugs. Drug resistance is the most useful in further evaluating the possibilities of reducing tumor mass or eliminating cancer by discovering new therapies. One of the key questions concerns the necessity of identifying superficial as well as intracellular markers, which are essential if the drug is to respond positively to CSCs. In recent years, CD133, CD44, ABCG2, and ALDH have been identified as biomarkers for certain forms of CSCs. However, recent studies have contributed to a better understanding of CSC-specific antigens; to date, there is no univocal characterization of antigens for CSCs. Our chapter aims to highlight the importance of identifying new markers to develop new therapeutic strategies against cancer
The sternum reconstruction: Present and future perspectives
No full textSternectomy is a procedure mainly used for removing tumor masses infiltrating the sternum or treating infections. Moreover, the removal of the sternum involves the additional challenge of performing a functional reconstruction. Fortunately, various approaches have been proposed for improving the operation and outcome of reconstruction, including allograft transplantation, using novel materials, and developing innovative surgical approaches, which promise to enhance the quality of life for the patient. This review will highlight the surgical approaches to sternum reconstruction and the new perspectives in the current literature
Letter from R. R. Zellick, Assistant Trust Officer, Anglo California National Bank of San Francisco, to Joseph R. Goodman, October 2, 1942
No full textLetter from R. R. Zellick, Assistant Trust Officer at The Anglo California National Bank of San Francisco, to Joseph R. Goodman, regarding property owned by Dave Tatsuno. Zellick mentions a dispute between current tenants and Tatsuno, and that Tatsuno has asked Goodman to help locate trustworthy tenants.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
Un modello di calcolo delle criticità nei sistemi di drenaggio urbano
No full textAtti del II Convegno di idraulica urban
Combined use of tracer and ERT tests as effective tool for the investigation of heterogeneous alluvial aquifers
No full textThe presence of preferential groundwater transport was investigated in the heterogeneous alluvial aquifer of the upper Alento River, located in Campania (southern Italy), in a fluvial sector characterised by braided geomorphology and sedimentary deposition.
Groundwater tracing methods were applied by means of two-well tracer tests (natural and forced-gradient tracer tests) and the inflow of a fluorescent dyes detected by a mobile downhole fluorometer. Tracer concentrations monitored over the entire screened interval of the well (8 m long) and the breakthrough curves obtained at different depths highlight that the tracer appears only over a limited length of the screen interval. The results suggest that groundwater flow occurs trough alternative paths according to the complex geometrical and granulometric features of the underlying deposits, so that groundwater flow (direction and specific discharge) varies with depth.
These results have been confirmed by using of electrical resistivity tomography (ERT) that indicates, within alluvial deposits, the presence of two distinct electrostratigraphic horizons. The topmost superficial one, characterised by greater resistivity values, can be related to more coarse alluvial sediments with little finegrained
matrix and likely to more permeable materials. This evidence supports the thesis of a non-uniform groundwater flow within a high heterogeneous aquifer.
The results emphasise the usefulness of tracer tests and ERT as effective tools for the investigation of aquifer heterogeneity in studies concerning the fate of dissolved pollutants
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