1,721,038 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Reference Intervals and innovative parameters using Sysmex XN-2000V in horses
No full textThe evaluation of the hemogram is a key component in diagnosing diseases and monitoring animal health. This study aims to establish reference intervals (RIs) for healthy horses using a next-generation hematology analyzer designed for veterinary medicine (Sysmex XN-2000V). In addition to conventional hemogram parameters, this instrument provides innovative indices such as immature reticulocyte fraction (IRF) and can determine platelet count by three methods: impedance (PLT-I), optical (PLT-O), and fluorescence (PLT-F). Moreover, a specific fluorescent platelet channel can determine an important thrombopoietic marker named immature platelets fraction (IPF).
For this study, hemograms from 50 clinically healthy adult horses were analyzed. Mean, median and standard deviation were assessed, and RIs were calculated using the percentile method (2.5%; 97.5%). The following RIs were determined: HCT (26.94–39.24 %), HGB (9.89–14.10 g/dl), RBC (5.5–8.3 10^6/μL), MCH (15.52–17.90 g/dl), MCHC (34.16–37.40 g/dl), MCV (43.13–50.04 fL), RDW (19.4–22.27 %), RET-HE (18.90–24.50 pg), RETICULOCYTES (0.05–0.22 %), RPI (0.00–0.10), WBC (4.50–8.70 10^3/μL), corrected WBC (4.50–8.70 10^3/μL), BAS (0.00–0.10 10^3//μL), EOS (0.00–0.30 10^3/μL), LYMPH (1.30–3.47 10^3/μL), MON (0.20–0.40 10^3/μL), NEU (2.40–5.41 10^3/μL), MPV (7.12–8.70 fL), PCT (0.08–0.13 %), PLT-I (61.20–152.80 10^3/μL), PLT-O (96.90–170.00 10^3/μL), PLT-F (96.75–160.60 10^3/μL), HFR (0.00–11.40 %), IRF (0.00–11.8 7%), LFR (59.95–100.00 %), MFR (0.00–2.14%), IPF (0.30–4.06 %), PDW (6.51–15.21 fL), P-LCR (4.32–15.21 %), IPF# (0.4–4.14 10^3/μL).
Establishing species-specific RIs based on the analytical instrument used is essential for accurately assessing the health status of both healthy and diseased horses, covering both standard and innovative parameters.
[1] O. Jornet-Rius, M. Mesalles-Naranjo and J. Pastor, “Performance of the Sysmex XN-V hematology analyzer in determining the immature platelet fraction in dogs: A preliminary study and reference values”, Vet. Clin. Pathol., vol 52, pp. 433-442, 2023
[2] K.R. Friedrichs, K.E. Harr, K.P. Freeman, B. Szladovits, R.M. Walton, K.F Barnhart and J. Blanco-Chavez, “ASVCP reference interval guidelines: determination of de novo reference intervals in veterinary species and other related topics”, Vet. Clin. Pathol, vol. 41, pp. 441-453, 2012
[3] A. Gavazza, C. Fani, C. Masci and G. Rossi, “Performance of platelet determination using the Sysmex XN 2000V analyzer and reference intervals in horses”, Proc. 26th ESVCP Congress, Budapest, pp. 140, August 2024
[4] M. Quagliardi, L. Galosi, G. Rossi, A. Roncarati and A. Gavazza, “Reference Intervals (RIs) in Veterinary Medicine”, ACTA IMEKO, vol 13, pp 1 – 5, 202
Effect on anterior temporalis surface EMG of eyes open-closed condition
No full textThe use of rest surface EMG of jaw elevator muscles is still debated. The low voltage recorded in anterior temporalis muscle by electromyography (EMG) in rest position could be affected by electronic noise or by activity coming from other muscles. Our goal was to evaluate the physiological behaviour of the anterior temporalis by surface EMG at rest mandible position during open or closed eyes condition in healthy young subjects without both malocclusion and visual defect. Surface EMG of anterior temporalis, masseter, digastric, sternomastoid muscle and mandible kinesiographic movement were recorded in 20 young, healthy individuals without both malocclusion and visual defect during open-closed eyes condition. No significant difference was found in surface EMG of anterior temporalis comparing eyes closed to eyes open condition. Physiology of open-closed eyes in healthy, young subjects without malocclusion or visual defect does not imply a change in surface EMG of anterior temporalis muscle
Three-year follow-up of chronic hepatitis C patients treated with ribavirin plus interferon-alfa combination therapy: Evidence for long-term efficacy and safety
No full textTo date, seven apomucins have been characterized and their expression in malignant and premalignant lesions is under evaluation. In this study, we examined the expression of MUC1, MUC2, MUC3, and MUC5/6 apomucins in cholanglocarcinoma (CC) and biliary epithelial dysplasia. We used 14 liver samples from patients with hepatolithiasis and CC, 11 with hepatolithiasis showing biliary epithelial dysplasia, 31 with CC alone (19 hilar, 10 peripheral, and 2 unclassifiable), and 14 with combined hepatocellular- cholangiocellular carcinoma (HC-CC) and immunohistochemically characterized the expression profiles of apomucins. Noudysplastic biliary epithelial cells in the intrahepatic large bile ducts constantly expressed MUC3 apomucin. MUC5/6 and MUC3 apomucin expression was widespread in dysplastic biliary epithelial cells in hepatolithiasis, although the latter was reduced or absent in dysplastic foci. CC extensively expressed MUC1 apomucin and focally expressed MUC2 apomucin. In addition, CC of the hilar type, including those with hepatolithiasis, frequently expressed MUC3 apomucin (68% and 57%, respectively), whereas those of the peripheral type infrequently expressed MUC3 apomucin (10%) (P < .01). MUC5/6 apomucin was more frequently expressed in well-differentiated (89%), compared with poorly differentiated CC (42%) (P < .01). Cholangiocellular elements of combined HC-CC frequently expressed MUC1 apomucin, although they rarely expressed MUC2 and MUC3 apomucin and infrequently expressed MUC5/6 apomucin. The frequent and aberrant expression of 'gastric type' MUC5/6 apomucin in biliary epithelial dysplasia, as well as in CC, suggests that biliary epithelial cells gain a gastric apomucin phenotype during carcinogenesis. MUC3 apomucin expression in CC is a marker that suggests that CC arises in the intrahepatic large bile ducts
Serum IgM antibodies to hepatitis C virus in acute and chronic hepatitis C
No full textA standardized commercially available immunoassay is not available for detection of IgM antibodies against hepatitis C virus antigens (IgM anti-HCV). Therefore, different ''in-house'' enzyme immunoassays have been assessed. These assays vary greatly in sensitivity, but specificity seems satisfactory in all of them. A typical IgM antibody response to HCV antigens is usually found in nearly all patients with acute hepatitis C. This antibody response rarely precedes the appearance of IgG anti-HCV, and it persists for a few months at high titer. Low titers of IgM anti-HCV are detectable in 50-80% of cases with chronic hepatitis C. IgM anti-HCV reactivity is typically found during acute exacerbation of chronic hepatitis C. Furthermore, many patients with chronic active hepatitis C without acute exacerbation also have IgM anti-HCV. In these patients a correlation exists between the titer of IgM anti-HCV and the biochemical parameters of liver disease. When alpha interferon therapy induces a sustained remission of liver disease activity, positivity for IgM anti-HCV disappears in more than 70% of cases. In contrast, patients who do not respond to therapy rarely loose IgM anti-HCV. In conclusion, serum IgM antibodies to HCV antigens are reliable markers of active HCV-induced liver disease both in acute and in chronic HCV infection
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Risky decline? Exploring the determinants of pupil's proficiency development over time
Full text linkThe early identification of at-risk students and of factors influencing proficiency development are crucial in education policy. This study investigates how students' fluctuations in academic performance during primary school impact the probability of being at-risk in Mathematics and Reading by the end of lower secondary school. Leveraging longitudinal data from 278,765 students in Italy, this study employs a multilevel multinomial model with Markov chain Monte Carlo (MCMC) techniques to explore personal, class, and school-related factors steering shifts between proficiency and non-proficiency. Findings highlight the importance of these transitions in predicting at-risk students at grade 8, emphasizing the role of peers' academic achievements and the variation across schools in shaping proficiency development
Dental enamel, fluorosis and amoxicillin.
No full textINTRODUCTION: Amoxicillin is one of the most used antibiotics among pediatric patients for the treatment of upper respiratory tract infections and specially for acute otitis media (AOM), a common diseases of infants and childhood. It has been speculated that the use of amoxicillin during early childhood could be associated with dental enamel fluorosis, also described in literature with the term Molar Incisor Hypomineralization (MIH), because they are generally situated in one or more 1st permanent molars and less frequently in the incisors. The effect ofAmoxicillin seems to be independent of other risk factors such as fluoride intake, prematurity, hypoxia, hypocalcaemia, exposure to dioxins, chikenpox, otitis media, high fever and could have a significant impact on oral health for the wide use of this drug in that period of life.
OBJECTIVE: The aim of this work was to review the current literature about the association between amoxicillin and fluorosis.
METHODS AND RESULTS: A literature survey was done by applying the Medline database (Entrez PubMed); the Cochrane Library database of the Cochrane Collaboration (CENTRAL). The databases were searched using the fol-lowing strategy and keywords: amoxicillin* AND (dental fluorosis* OR dental enamel*) and MIH*. After selecting the studies, only three relevant articles published between 1966 and 2011 were included in the review.
CONCLUSION: The presence of several methodological issues does not allow to draw any evidence-based conclusions. No evidence of association was detected, therefore, there is a need of further well-designed studies to assess the scientific evidence of the relationship between amoxicillin and fluorosis and to restrict the prescription of this drug for recurrent upper respiratory tract infections especially acute otitis media (AOM) during the first two years of life. When it is possible can be opportune to use an alternative antibiotic treatment
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