1,721,663 research outputs found

    PER UN MUSEO DEL DESIGN E DELLA CULTURA MATERIALE ALLA SAPIENZA. CONDIZIONI DI CONTESTO E PROSPETTIVE

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    Il progetto di un nuovo museo del Design e della Cultura Materiale da inserire nel Polo Museale della Sapienza, potrebbe rispondere pienamente agli obiettivi di rilancio dell’ateneo e a numerose altre esigenze di contesto. Un museo è un mezzo per scoprire e conoscere il futuro attraverso il passato, da cui discende che la creazione di un centro museale alla Sapienza con la raccolta e l’archiviazione di prodotti materiali e immateriali sul Design, avrebbe un valore storico-scientifico elevatissimo nonché strategico per le prospettive dell’ateneo. Nessuna istituzione pubblica in Italia è riuscita a portare a termine il progetto di un museo del Design e della Cultura Materiale in grado di accogliere le istanze e le sperimentazioni provenienti da tutti i territori della nazione e dal mondo intero. Il nuovo museo della Sapienza poiché insediato in un nucleo architettonico straordinario, potrebbe fondarsi proprio su un primo nucleo di eccezionale pregio, costituito dal patrimonio di arredi e artefatti coevi alla fondazione della Città Universitaria, per poi includere progetti e prodotti realizzati nel territorio regionale e nazionale, ed accogliere infine in un archivio di documenti e progetti provenienti da donazioni private, oggi a forte rischio di dispersione.The project of a new museum of Design and Material Culture to be included in the Polo Museale of Sapienza University could fully meet the objective of revitalizing the University and reaching numerous other contextual achievements. A museum is a vehicle to discover and know the future through the past, therefore the creation of a Sapienza museum center that collects and stores material and immaterial Design artefacts would have a very high historical and scientific as well as strategic value for the university prospects. No public institution in Italy has managed to complete the project of a museum of Design and Material Culture capable of welcoming requests and experiments from all national and international territories. Since the Polo Museale of Sapienza University is located in an extraordinary architectural scenario, the new museum would be founded on a first nucleus of exceptional value, consisting of the heritage of furnitures and artifacts coeval with the foundation of the Città Universitaria, then it might include projects and products made in both regional and national territory, and finally host an archive of documents and projects from private donations, today at a high risk of dispersion

    Magnesium deprivation affects development and biomineralization in the sea urchin arba-cia lixula

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    Skeletogenesis is a key morphogenetic event in the life of marine invertebrates. Marine calcifiers secrete their calcareous skeletons taking up ions from seawater. Marine biominerals include aragonite and calcite, the latter of which in some taxa (e.g. echinoderms, coralline algae) can have a substantial magnesium (Mg) component. Echinoderms have an extensive endoskeleton composed of high magnesian calcite and occluded matrix proteins1. As biomineralization in sea urchin larvae is sensitive to the Magnesium:Calcium ratio of sea water, we investigated the effects of magnesium deprivation on development and skeletogenesis in the Mediterranean sea urchin Arbacia lixula. Microscopic inspection revealed that embryos reared in Mg-free seawater exhibited developmental delay from 6 hours post-fertilization, complete lack of skeleton formation at 24 hours, and severe skeleton malformations in larvae (48-72 hours). We subsequently focused on the localization of the skeletogenic cells (primary mesenchyme cells) and the spatial expression of associated genes. Immunocytochemistry revealed abnormal ectopic location of the primary mesenchyme cells (PMCs) and of the developing skeleton of treated embryos. Expression of msp130, an important skeleton matrix protein gene expressed only in PMCs, detected by in situ hybridization, was normal at 24 hours, but this gene was not down-regulated at 48 hours, as in controls2. Strikingly, development of the pigment cells, immune cells that, like the skeleton, are mesodermal derivatives, was also impaired. These results suggest the essential role of Mg in skeleton formation in sea urchin embryos with an indication that this element is also generally important for development of mesoderm. 1. Smith AM et al. Mar Ecol Prog Ser 2016, 561:1–16 2. Martino C et al. Aq tox 2018, 194:57-66

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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