1,721,077 research outputs found
Haploidentical hematopoietic stem cell transplantation with a megadose T-cell-depleted graft: harnessing natural and adaptive immunity.
No full textFor patients with high-risk acute leukemia who do not have a matched donor or who urgently need
a transplant, transplantation from a full human leukocyte antigen (HLA) haplotype mismatched
family donor should be considered a viable option. Clinical trials have shown that a strategy for
haploidentical transplantation based on the infusion of high numbers of T-cell– depleted hematopoietic
progenitor cells and no post-transplant immunosuppression controls bi-directional T-cell
alloreactivity, ie, graft rejection and graft-versus-host disease (GvHD) in patients with leukemia.
Overall, event-free survival compares favorably with reports of transplants using sources of stem
cells other than the matched sibling. This transplant modality has highlighted the crucial role of
donor-versus-recipient natural killer cell (NK) alloreactivity in the control of leukemia relapse.
Current studies are focusing on rebuilding post-transplant immunity to improve clinical outcomes
ACQUISITION OF IG ISOTYPE DIVERSITY AFTER BONE-MARROW TRANSPLANTATION IN ADULTS - A RECAPITULATION OF NORMAL B-CELL ONTOGENY
No full textTo gain insight into the prolonged susceptibility to infections noted after allogeneic bone marrow transplantation (BMT), multiple parameters of the humoral immune system were serially monitored in ten bone marrow recipients. IgM B cells appeared in the circulation 2 to 4 mo after engraftment. During the first 6 mo, the IgM B cells expressed low levels of CD21 (C3d/EBV receptors) and were largely CD38+. IgG and IgA B cells were also found to coexpress surface IgM and IgD, indicating that they may be involved in a process of isotype switch. These features are characteristic of neonatal B cells. To explore the pattern of Ig isotype switch, the emergence of plasma cell precursors for each of the four IgG subclasses was examined by culturing blood lymphocytes with PWM or LPS and enumerating bone marrow plasma cells. A marked IgG2 and IgG4 plasma cell deficiency and a relative increase in IgG1 and IgG3 plasma cells were detected both in vitro and in vivo. Serum IgG2 and IgG4 levels were deficient for more than 18 mo after BMT, elevated IgG1 levels accounting for the normal or increased levels of total IgG. The data suggest that a selective unresponsiveness to polysaccharide Ag and IgG2 subclass deficiency may contribute to the late bacterial infections in BMT recipients. These features of gradual development of the humoral immune system in adults undergoing successful marrow engraftment reproduce some of the maturational steps that occur during normal B cell ontogeny over the first 1 to 2 yr of lif
Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues.
No full textMonoclonal antibody-defined T-cell phenotypes and phytohemagglutinin reactivity of E-rosette-forming circulating lymphocytes from untreated chronic myelocytic leukemia patients.
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Comparative genomic hybridization identifies 17q11.2~q12 duplication as an early event in cutaneous T-cell lymphomas.
No full textMutational landscape of AML with normal cytogenetics: biological and clinical implications
No full textThe in vitro effect of a calf thymus extract (thymostimulin) on T cell phenotypes in cord blood lymphocytes.
No full textT lymphocytes transduction with herpes simplex virus-thymidine kinase (HSV-tk) gene: comparing four different infection protocols
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