1,721,029 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Pyrrole-Based Hydroxamates and 2-Aminoanilides: Histone Deacetylase Inhibition and Cellular Activities
No full text(Chemical Equation Presented) Pyrrole-based HDAC inhibitors: Pyrrolyl-hydroxamates (3 a-g) and 2-aminoanilides (4 a-g) derived from the class II-selective histone deacetylase (HDAC) inhibitor MC1568 (1) were prepared and tested against human recombinant HDAC1, HDAC4, and HDAC6. Unlike compound 1, most of the tested compounds inhibited both HDAC1 and HDAC6, and were less potent or completely inactive against HDAC4. Consistent with their high HDAC1/HDAC6 inhibition, compounds 3 a and 3 b induced>20 % cell death in U937 cells at 1m. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
The clinical value of HDAC2 and the p53-dependent signalling pathway in colorectal cancer
No full textColorectal cancer (CRC) is a leading cause of international morbidity and the second highest
cause of cancer-related mortality. Incidence risks associated with CRC may be both
environmental and behavioral, while disease complexity is characterized by genetic and
epigenetic alterations. The up-regulation of the epigenetic regulator HDAC2 is one of most
premature events in CRC carcinogenesis, while CRC progression is regulated by a series of
mutations and chromosomal deletions of key oncogenes or tumor suppressor genes such as
p53. One of the primary obstacles in accurately diagnosing CRC is the presence of mutations
in the p53 gene, which disrupts the DNA mismatch repair pathway. Microsatellite instability
(MSI) is a distinctive characteristic of CRC, and mutations in the DNA mismatch repair
pathway are frequently observed. In 20% of cases, MSI in CRC is caused by the inactivation
of one allele of a mismatch repair (MMR) gene by a germline mutation and subsequent
somatic inactivation of the second allele. The remaining 80% of cases of sporadic tumours
involve the somatic inactivation of both alleles of MLH1 gene, which is involved in DNA
MMR by hypermethylation modifications (Lynch syndrome) or hereditary nonpolyposis colon
cancer. Understanding the interaction between HDAC2 and p53 could potentially aid in
identifying high-risk inherited colon cancer groups prone to developing CRC. HDAC2, a class
I deacetylase, plays a critical role in regulating gene expression and chromatin structure.
Research has demonstrated that CRC exhibits elevated levels of HDAC2, leading to enhanced
cancer cell proliferation and metastasis. The regulation of the tumor suppressor p53 is
influenced by HDAC2 through deacetylation, and HDAC2 also plays a role in maintaining
genomic stability. HDAC inhibitors (HDACi) impact the enzymatic activity of HDAC2,
indicating that this protein has a physiological function in cell proliferation, survival, and
differentiation. HDACi treatment affects both mutant and wild-type p53 forms in CRC,
although the exact mechanism is still unclear. Therefore the use of selective HDAC2 inhibitors
could represent a versatile therapeutic strategy for CRC. The aim of this study is to identify
HDAC2/p53 signatures that can enhance our understanding of CRC biology and to uncover
potential targets for therapeutic interventions
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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