608 research outputs found
Elementos teórico-conceptuales en relación con la naturaleza, la dinámica y el funcionamiento de las organizaciones en el contexto latinoamericano y del Caribe
No full textSe abordan reflexiones sobre empresas sociales, cooperativas, micro, pequeñas y medianas empresas (mipymes), innovación social, liderazgo, capacitación y aprendizaje, identidad organizacional, crítica de la racionalidad, certificación y calidad y la acción.Carlos Juan Núñez Rodríguez; Rosiluz Ceballos Povedano, coordinadore
Firmas de los diputados pertenecientes a los estado de Colima, Chiapas, Chihuahua, D.F., Durango
No full textInscripción en la guarda: "Firma de Diputados de Colima, Chiapas, Chihuahua, D.F., Durango". Nota. Los nombres de los diputado son: JORGE E. VON VERSEN, MANUEL CEPEDA MEDRANO, JOSE RODRIGUEZ GONZALEZ (SUPLENTE).- DIPUTADO POR EL EDO. DE COLIMA: FRANCISCO RAMIREZ VILLAREAL.- DIPUTADOS POR EL EDO. DE CHIAPAS: ENRIQUE SUAREZ, LISANDRO LOPEZ, DANIEL A.CEPEDA, CRISTOBAL LL. Y CASTILLO, J. AMILCAR VIDAL.-DIPUTADO POR EL EDO. DE CHIHUAHUA: MANUEL M. PRIETO. - DIPUTADOS POR EL DISTRITO FEDERAL: GRAL. IGNACIO L. PESQUEIRA, LAURO LOPEZ GUERRA, GERZAYN UGARTE, AMADOR LOZANO, FELIX F. PALAVICINI, CARLOS DUPLAN, RAFAEL L.DE LOS RIOS, ARNULFO SILVA, ANTONIO NORZAGARAY, CIRO B. CEBALLOS, ALFONSO HERRERA, ROMAN ROSAS Y REYES (SUPLENTE), LIC. FRANCISCO ESPINOSA (SUPLENTE).-DIPUTADOS POR EL EDO. DE DURANGO: SILVESTRE DORADOR, LIC. RAFAEL ESPELETA. Referencia: http://www.cem.itesm.mx/derecho/nlegislacion/federal/1/156.htm, (última consulta 13/04/2011)
Voces de la memoria. XXV aniversario de El Colegio de la Frontera Norte
No full textCon una trayectoria fructífera y muy exitosa El Colegio de la Frontera
Norte ha cumplido 25 años de ser un centro de investigación científica
de excelencia académica, de llevar a cabo su misión en la investigación,
la docencia y creando vínculos tanto con la sociedad como con las instituciones
del Estado mexicano en todos sus niveles. A cinco lustros de
distancia, puede afirmarse con plena justicia que nuestra institución ha
labrado un espacio propio entre las ciencias sociales del país y participa
del reconocimiento de la sociedad y los gobiernos, en particular, de la
frontera norte mexicana, a la cual hemos dedicado la esencia de nuestros
esfuerzos. Celebramos un primer cuarto de siglo en un horizonte de
largo plazo, una primera etapa, un primer cúmulo de trabajo, de dedicación
esmerada, de objetivos y metas cumplidos, de numerosos logros y
también retos pendientes
Fenómenos sociales y urbanos transfronterizos entre México y Estados Unidos
No full textEste libro reúne los trabajos presentados en el simposio "Fenómenos sociales y urbanos transfronterizos", organizado por El Colegio de la Frontera Norte el 28 de agosto de 2007, en el Archivo Histórico Municipal "Juan E. Richer", de la ciudad de Nuevo Laredo, Tamaulipas, con el objetivo de analizar aquellos fenómenos que involucran y vinculan a las comunidades de ambos lados de la frontera México-Estados Unidos. Se aborda temáticas que tienen que ver con los fenómenos transfronterizos, tales como: los hitos a considerar para el estudio de la historia fronteriza; el contexto laboral del Noreste de México y el Sur de Texas en el siglo XX; la interacción de los procesos urbanos, económicos y demográficos en la región; así como aspectos de las dinámicas familiares y los servicios de maternidad en la frontera de Tamaulipas y Texas- El análisis de lo transfronterizo entre México y Estados Unidos da sustento a la necesidad de incrementar el estudio de las relaciones que se dan en ese ámbito, mismas que son fundamentales para entender la frontera y sus demandas ante sus respectivos países, así como el papel de estos en el espacio (o espacios) de dicha región
Harbouring the secondary endosymbiont Regiella insecticola increases predation risk and reproduction in the cereal aphid Sitobion avenae
No full textSymbiosis in insects has been recognized as contributing to their ecological and evolutionary success. In the case of agricultural pests, endosymbionts may help insects colonize and expand their niches, allowing them to use different crops and to confront climatic variation. Moreover, endosymbionts provide improved defences against pathogens, predators, and parasitoids. In aphids, facultative endosymbionts have been found capable of generating these characteristics. However, evidence for this has been gathered from only a few model organisms. Here, we studied the effect of the facultative endosymbiont Regiella insecticola on the predation of Sitobion avenae clones by the ladybird Hippodamia variegata. In the laboratory, we assessed the predation rate of this coccinellid and the concomitant anti-predator behaviour of S. avenae with and without R. insecticola. We also evaluated the effect of the presence of this endosymbiont on the constitutive levels of E--farnesene, on the metabolic rate, and on the reproductive performance of S. avenae. All these traits were studied on two common alternative crops: wheat and barley. We found that R. insecticola-infected aphids were more predated irrespective of host plants and did not improve defences against coccinellid predators or metabolic rates on any host plants. Levels of E--farnesene were higher on wheat plants, irrespective of the presence of R. insecticola. Interestingly, R. insecticola-infected aphids had increased performance on wheat, while the opposite was true on barley. We discuss our findings based on the importance of secondary symbionts as providers of traits allowing aphids to be very invasive crop pests worldwide
Avaliação da ação citotóxica de cardenolídeos em células tumorais
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.Os cardenolídeos, tais como digoxina e oubaína, são conhecidos por sua eficácia no tratamento da insuficiência cardíaca congestiva e como fármacos antiarrítmicos. Recentemente, foram detectadas novas atividades farmacológicas para esses "antigos" fármacos. Tendo em vista o crescente interesse na pesquisa e desenvolvimento desta classe de compostos como potenciais quimioterápicos, frente a diversas linhagens celulares tumorais, o presente trabalho de tese objetivou avaliar os efeitos citotóxicos em células tumorais de três cardenolídeos (glucoevatromonosídeo, digitoxigenina monodigitoxosídeo e convalotoxina), previamente selecionados pela sua potente ação citotóxica. Inicialmente, eles foram avaliados em linhagens celulares tumorais de diferentes origens e todos demonstraram uma potente ação, em concentrações nanomolares, em todas as linhagens testadas, especialmente nas células de tumor de pulmão (A549). Essa linhagem tumoral foi então selecionada para a continuação dos experimentos para detectar o tipo de morte celular causada por esses três cardenolídeos. O glucoevatromonosídeo (GEV), composto mais promissor, também foi investigado em células U937 (linfoma histiolítico). Todos os três causaram bloqueio da fase G2/M, enquanto que a convalotoxina (CON) aumentou o número de células em subG0 do ciclo celular. O GEV foi capaz de inibir a expressão de importantes proteínas relacionadas ao ciclo celular, como ciclina B1 e p53 em A549. Ainda, esse composto causou bloqueio em subG0 em células U937, demonstrando um efeito dependente do tipo celular. O efeito de morte celular causado pelo GEV também foi tipo celular dependente, já que foi observada morte celular pela ação de caspases nas células U937 e independente da ação das caspases em células A549. A digitoxigenina monodigitoxosídeo não apresentou efeito significativo de morte celular em células A549. A CON aumentou o número de núcleos picnóticos e células Anexina-V positivas, configurando morte celular apoptótica. Alem disso, os três compostos foram capazes de inibir a migração e invasão celulares, em células A549, bem como de reduzir a expressão das proteínas: MMP2, MMP9 e FAK (proteína de adesão focal), que são essenciais no processo de metástase. Além disso, o GEV foi capaz de inibir a expressão de importantes cinases, geralmente super expressas em células tumorais. O conjunto desses dados sugere que estes compostos, especialmente o GEV, podem ser considerados candidatos promissores para o desenvolvimento de uma forma farmacêutica a ser usada no tratamento do câncer de pulmão.Abstract : Cardenolídeos such as ouabain and digoxin are known for their efficacy in treating congestive heart failure as antiarrhythmic drugs. Recently, new pharmacological activities have been found (antiviral and antitumor) to these "old" drugs. Given the growing interest in research and development of this group of compounds, as potential chemotherapeutic agents, this work aimed to evaluate the cytotoxic effects on tumor cells of three cardenolides (glucoevatromonoside, digitoxigenin monodigitoxoside and convallatoxin) previously selected for its potent cytotoxic action. Initially, they were screened in tumor cell lines of different origins and all of them showed potent action at nanomolar concentrations in all cell lines tested, particularly in lung tumor cells (A549). This cell line was then selected for further investigation to detect the kind of cell death caused by these three cardenolides. Glucoevatromonoside (GEV) was the most promising compound, and also investigated in U937 cells (histiocytic lymphoma). All these compounds block G2/M phase, whereas the convallatoxin increased the number of cells in subG0 phase. GEV was able to inhibit the expression of important proteins related to cell cycle, such as Cyclin B1 and p53. Beyond that, this compound caused cell cycle blockage in subG0 phase in U937 cells, demonstrating dependent cell type effect. The effect of cell death caused by GEV was also cell type dependent. In U937 cells, GEV showed a caspase dependent cell death while it is independent of caspase in A549 cells. Digitoxigenin monodigitoxoside did not show a significant percentage of cell death in A549 cells. Convallatoxin increased the number of pyknotic nuclei and Annexin-V positive cells, setting apoptotic cell death in A549 cells. Furthermore, the three compounds are capable of inhibiting cell migration and invasion in A549 cells as well as to reduce the expression of some proteins as MMP2, MMP9 and FAK (focal adhesion protein), which are essential in the process of metastasis. Moreover, GEV was able to inhibit the expression of important kinases, usually over expressed in tumor cells.. Taken together, these data suggest that these compounds, especially GEV can be considered promising candidates for the development of a pharmaceutical form to be used in the treatment of lung cancer
The myth of minority : cultural change in Valencia in the thirteenth century at the time of the conquests of James I of Aragon
No full textThe history of the Iberian Peninsula is intricate and complex. Like most regions of
Western Europe in the Middle Ages, it suffered invasion, occupation, political change and an almost constant re–alignment of social alliances. Yet the thirteenth century saw one of the most massive shifts in the balance of power recorded in western history. In the space of fifty years, Islamic rule within the peninsula was ended for good, with the last vestiges of Muslim territory erased from the southern peninsula by the fifteenth century. Christian ascendancy heralded the arrival of a mixed policy of tolerance, as questions began to be asked about the nature of living together with other cultures and religions and whether this new rule – this new Christian rule – needed to tolerate the existence of others in its midst.
The most dramatic shift in policy occurred in the middle of the thirteenth century, as the campaigns of the two great northern kingdoms of Leon–Castile and Aragon–Catalonia moved southwards. The most dramatic outcome – due to the size of the Muslim population – was the relatively swift conquest of, in the case of Ferdinand III, the main towns of Andalucia and, in the case of James I, king of Aragon, the region of Valencia by 1245. Yet it is important when examining the campaigns of these great warrior kings not
to be overwhelmed by the idea of the religious ethos for the conquest. Some historians have chosen to interpret the thirteenth–century conquests as the Christian reaction for the centuries of subjugation under Muslim rule. The reasoning behind the conquests was far more complex than that of a mere idealistic crusade. In the case of thirteenth–century Christian expansion, desire for territory, sovereignty, inheritance, taxation and inter-territorial rivalry had just as much of a part to play as a desire to overcome the Muslim ‘infidel.’ It is the conquest of Valencia which will form the major focal point of this paper, examining the historical precedent for conquest, the nature of Muslim rule, the ulterior motives of the Christians, the
position of Muslims and Jews in existing Christian society (as well as under the
conquerors) and the role of James I in both consolidating and changing that culture.
The programme of this thesis is divided into two main parts. In the first part, the paper will explore the impact of historical events up to the birth of James; how these events both shaped him as a king and as a warrior; and how domestic concerns may have provided a greater incentive than religious missionaries spreading Crusading fever amongst Western kingdoms. It will review the impact of those close to the king; on the nature of his conquest; on his ideology; and how his attitude towards his conquered subjects was shaped. External political and geographical pressures impacted both upon the king’s campaigning and, ultimately, how complete the conquest was.
In the second part, the thesis will focus on the communities themselves and the changes that occurred as the conquests progressed further and further southwards. It will
contrast the circumstances and fortunes of those conquered with the lives of minority
cultures who were already subjects in the Christian realms. It will examine the idea of
hierarchy within minority culture and the social mores that had an even more direct
impact upon community life than the military campaigning. Most important of all, it will
question the idea of convivencia and the concept of tolerance and ‘living together.
Emission of nitrous oxide and carbon dioxide and dynamics of mineral N in wastewater sludge, vermicompost or inorganic fertilizer amended soil at different water contents: A laboratory study
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