169,907 research outputs found
Gamma-glutammiltransferasi (GGT): biochimica clinica e patologia umana (Rassegna)
No full textγ-glutamyltransferase: clinical biochemistry and human pathophysiology. Serum γ-glutamyltransferase (GGT)
activity is a sensitive test of liver function, but its clinical use is limited by the low specificity. This paper reviews the
biochemical characteristics and physiological functions of GGT, the aspects of serum GGT measurement and the
epidemiological and biochemical evidence related to the clinical meaning of serum GGT in human pathology and the
role of membrane GGT in tumors. Epidemiological studies have shown that GGT values still within the reference
interval are positively associated with the risk of onset and evolution of atherosclerotic process and related diseases,
such as hypertension, type II diabetes, and metabolic syndrome. The relevance of the predictive value of serum GGT
has been recently increased by studies showing the association of GGT concentrations with the risk and prognosis
of cancer and renal disease. Serum GGT has also been proposed as marker of exposure to environmental
xenobiotics, which may directly induce oxidative stress
“Valutazione del comportamento aggressivo di soggetti in età compresa tra 11 e 14 anni”, IV° Congresso Nazionale della Società Italiana di Psicopatologia Roma
No full text“Valutazione delle analogie o differenze del comportamento aggressivo tra soggetti in età compresa tra 11 e 14 anni e adulti”, IV° Congresso Nazionale della Società Italiana di Psicopatologia Roma.
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
On the Causes and Consequences of Divorce
No full textIn most Western economies, the flourishing of the Welfare State has coincided with a decline of the role of the family: divorce has been introduced, and the number of marriages has decreased. We suggest that a taboo against divorce was part of the informal safety net in a period when social protection was provided by the family. Once the State started offering suitable alternatives, the taboo was no longer expedient, and was dropped. For the same reasons, marriage has become less popular. We further notice that divorce is an extremely costly process, and once allowed it may act as an independent reason for the reduction of the number of marriages. This latter result is especially evident under the assumption that agents subjectively evaluate the probability of facing a divorce using an availability heuristic.divorce, marriage, availability heuristic
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