1,721,446 research outputs found
Efficacy and tolerability of antiretroviral therapy: focus on people with HIV or on PrEP
No full textUse of tomographic nuclear medicine procedures, SPECT and pinhole SPECT, with cationic lipophlic radiotracers for the evaluation of axillary lymph node status in breast cancer patients
No full textReply letter - “Safety and efficacy of oral lopinavir/ritonavir in pediatric patients with coronavirus disease: A nationwide comparative analysis”
No full text
Detection of axillary lymph node metastases in breast cancer with Tc-99m tetrofosmin scintigraphy.
No full textInt J Oncol. 2002 Mar;20(3):483-7.
Detection of axillary lymph node metastases in breast cancer with Tc-99m tetrofosmin scintigraphy.
Schillaci O, Scopinaro F, Spanu A, Donnetti M, Danieli R, Di Luzio E, Madeddu G, David V.
SourceUniversity of Rome, Rome, Italy. [email protected]
Abstract
The most important prognostic factor in breast (B) cancer (C) is axillary (A) lymph (L) node (N) status, and virtually all patients with BC undergo ALN dissection to assess N involvement. The aim of this study was to evaluate the accuracy of planar and tomographic Tc-99m tetrofosmin scintigraphy in the detection of ALN involvement in BC. A group of 85 female patients (age range: 31-82 years) with 87 BCs were studied before surgery. Three planar images, right and left prone lateral and supine anterior thoracic views, and 360 degrees supine thoracic single photon emission tomography (SPET) were acquired after Tc-99m tetrofosmin injection (740 MBq i.v.). ALN status was evaluated by histological exam after A dissection: metastatic ALN involvement was proved in 31 out of 87 cases. Sensitivity was 87.1% (27/31) for SPET and 61.3% (19/31) for planar images (p3 metastatic Ns and in 10/13 (76.9%) with < or = 3 involved Ns, whereas planar images were positive in 14/18 (77.8%) and in 5/13 (38.5%) cases, respectively. In conclusion, our findings indicate that Tc-99m tetrofosmin scintigraphy is useful in the presurgical detection of ALN metastases in BC, with SPET more accurate than conventional planar images, thus suggesting its more frequent use in scintimammography; moreover, the total number of histologically involved Ns can affect the scintigraphic results.
PMID:11836558[PubMed - indexed for MEDLINE
Studio istoimmunologico del carcinoma tiroideo in pazienti con alti livelli serici di calcitonina, antigene carcinoembrionario e tireoglobulina
No full text
Thyrotropin (TSH) and prolactin (PRL) responses to thyrotropin releasing hormone (TRH) in chronic alcoholism (CA) and in liver cirrhosis (LC)
No full textTrends in the European HIV/AIDS epidemic: a perspective from Italy
No full textThe HIV/AIDS epidemic represents one of the major public-health challenges in present days. Despite the relevant improvement in the prognosis of HIV disease following the introduction of highly active antiretroviral therapy (HAART), numerous new challenges are progressively emerging as patient characteristics evolve. In this article, we give an insight into more actual topics in the HIV/AIDS epidemic in Italy and Europe, including recent epidemiological trends, emerging drug resistance and non-B-subtype circulation, the lights and shadows of HAART and the potential of HARRT to reduce sexual transmission of HIV
Molecular breast imaging with gamma emitters
No full textFollowing a diagnosis of breast cancer (BC), the early detection of local recurrence is important to define appropriate therapeutic strategies and increase the chances of a cure. In fact, despite major progress in surgical treatment, radiotherapy, and chemotherapy protocols, tumor recurrence is still a major problem. Moreover, the diagnosis of recurrence with conventional imaging methods can be difficult as a result of the presence of scar tissue. Molecular breast imaging (MBI) with gamma-ray emitting radiotracers may be very useful in this clinical setting, because it is not affected by the post-therapy morphologic changes. This review summarises the applications of 99mTc-sestamibi and 99mTc-tetrofosmin, the two most employed gamma emitter radiopharmaceuticals for MBI, in the diagnosis of local disease recurrence in patients with BC. The main limitation of MBI using conventional gamma-cameras is the low sensitivity for small BCs. The recent development of hybrid single photon emission computed tomography/computed tomography devices and especially of high-resolution specific breast cameras can improve the detection rate of sub-centimetric malignant lesions. Nevertheless, probably only the large availability of dedicated cameras will allow the clinical acceptance of MBI as useful complementary diagnostic technique in BC recurrence. The possible role of MBI with specific cameras in monitoring the local response of BC to neoadjuvant chemotherapy is also briefly discussed
- …
