1,721,032 research outputs found
Closed-Chamber Pulling-Injection System for donor graft insertion in endothelial keratoplasty
No full textI describe the closed-chamber pulling-injection (CCPI) technique to improve surgical control and safety of graft insertion into the anterior chamber during Descemet-stripping automated endothelial keratoplasty (DSAEK). In CCPI, the graft is rolled up (endothelium facing inward) in a closed transparent insertion device, allowing it to be drawn into a well-formed anterior chamber and unfolded smoothly. The technique has been used successfully to treat corneal decompensation in 72 consecutive cases. The results indicate that using the CCPI technique, both average and complicated cases can benefit from the numerous advantages provided by endothelial keratoplasty
A more efficient way to measure standardized visual acuity with charts: the "fast" procedure
No full textSTRUMENTO CHIRURGICO PER MANIPOLARE E INSERIRE NELL’OCCHIO UNA LAMINA DI CELLULE, IN PARTICOLARE UN SUPPORTO SOTTILE DI STROMA CON CELLULE ENDOTELIALI, PER TRAPIANTI CORNEALI
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Electrophysiology of retina and optic nerve: effects of changes in serum glucose and of exogenous adenosine in vitro
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Changes in glucose level affect rod function more than cone function in the isolated, perfused cat eye
No full textThe glucose concentration (gl) in mammalian serum incorporates a normal range of variation of several millimoles. We studied the effects of such variations on light-evoked electrical signals in the in vitro arterially perfused cat eye, avoiding extraocular regulatory mechanisms that might confound data interpretation. Changes in gl from the nominal control value of 5 mmol/1 were maintained for 5-40 min. Stimuli of near rod threshold intensity were presented in full dark adaptation, and stimuli of higher intensity were presented in the presence of a white background for cone responses. We recorded the dc-electroretinogram (ERG), the scotopic threshold response (STR), the optic nerve response (ONR), and the transretinal slow P-III and transepithelial retinal pigment epithelium c-wave from the subreti-
nal space. The ocular standing potential changed by up to ±2 mV in parallel with an increase and decrease in gl, independent of the adaptation condition. Our results show that the rod-ERG, STR, and rod-driven optic nerve response (ONR) have a marked sensitivity to small changes in gl (±1 to 3 mmol/1). The field potentials increased and decreased in parallel with changes in gl. The cone ERG and cone ONR, in contrast, failed to respond consistently to increases in gl and revealed decreases in amplitudes only with an extreme decrease in gl. Decrease in gl, down to 2 mmol/1 and less, is known to induce drastic behavioral and electrophysiologic phenomena in the central nervous system. Our results imply that the "normal" glucose level, at least in the cat, could be marginal for rod-mediated retinal function. The results also suggest a marked difference in metabolic mechanisms for cone versus rod photoreceptor
Chemotherapy-associated peripheral sensory neuropathy assessed using in vivo corneal confocal microscopy
No full textPeripheral neuropathies are a frequent complication of antineoplastic therapy. Capecitabine is known to induce peripheral sensory neuropathy. However, the diagnosis requires invasive examinations such as electrophysiology tests or peripheral skin biopsy. In vivo confocal microscopy represents a promising, noninvasive new tool in the study of chemotherapy-induced peripheral neuropathy, which often occurs in complex patients who are not always willing to have further testing. In vivo confocal microscopy should be considered a useful tool in the diagnosis and follow-up of chemotherapy-induced peripheral neuropathies, given its low invasiveness, repeatability, and low cost
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