1,720,961 research outputs found
Prospective cost-effectiveness study of regular continuous prophylactic replacement therapy in adults with severe hemophilia A
No full textBackground: Prophylaxis is effective in children with haemophilia. Adults with advanced haemophilic arthropathy can probably benefit from a continuous prophylactic replacement therapy (PRT), but no data are available on cost end efficacy.
Methods: A prospective study was designed to evaluate cost-effectiveness of PRT with a B-domain-deleted recombinant FVIII in adults with severe haemophilia, aged 18–60 years, with ‡18 bleeds in the previous year. PRT: 25 IU kg-1 of Refacto® 3 times a
week for 6 months. Bleeding rate and FVIII consumption was evaluated over the previous 6-month on-demand treatment (ODT) period and the PRT period. Medical costs were quantified adopting the perspective of the National Health Service. The incremental cost-effectiveness ratio (ICER) was calculated as ratio of cost and bleed difference of ODT and PRT. Confidence intervals (CIs) were generated by non-parametric bootstrap procedure. A cost-effectiveness plan and acceptability curve were created.
Results: Nineteen patients, aged 23–58 years (mean = 33.2) with a mean of 2.97 events/patient/ month (median = 1.67, range: 0.5–15) were enrolled. Bleeding frequency decreased to 0.48 events/ patient/ month. The incremental cost of PRT vs. ODT was
estimated to be € 11,619/patient/month (95% CI € 7,649–15,589) with an additional effect of 2.49 bleeds avoided/patient/month (1.06–3.93). The ICER was estimated to be € 5184 per bleed avoided (€1,071–9,297). The likelihood of PRT being cost-effective was 95% with a ceiling ratio of € 9000 per bleed avoided.
Conclusions: These findings showed PRT with Refacto® in adults with haemophilia is cost-effective, but it requires more resources than ODT. Our cost-effectiveness results can represent the reference for other similar evaluations
Quality of life of paediatric patients with atopic dermatitis and their families : the CODA study
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
PSK11 CARE GIVERS' WILLINGNESS TO PAY FOR DIFFERENT CHARACTERISTICS OF THE ATOPIC DERMATITIS TREATMENT
No full textAppropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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