120 research outputs found
Changes in soil phosphorus (P) fractions and P bioavailability after 10 years of continuous P fertilization
No full textPhosphorus fertilization modify soil P fractions differing in availability, but little is known about bioavailability of these pools for the crops when increasing P fertilizer rates in the medium term. Our objectives were to evaluate: i) changes in Bray-1 P content (extracted with 0,03 M NH4F and 0,1 M HCl) and soil P fractions as estimated by physical (Cambardella and Elliot method, POM-P) and chemical fractionation (Hedley method), ii) the relationship between these fractions and P bioavailability quantified in a test crop, and iii) the interaction with sulfur (S) fertilization after 10 years of continuous P and S fertilization. Soil samples were taken after 10 years in an experiment that followed a maize - full season-soybean - double-cropped wheat /soybean sequence that received P and S fertilization when cereals were sown. Treatments consisted of a factorial combination of three P rates (0, 20, and 40 kg P ha−1) and four S rates (0, 12, 24, and 36 kg S ha−1) applied to cereals from 2000 to 2010. After that, a maize used as a test crop was sown and P uptake was considered as bioavailable P. Soil samples were taken before sowing the test crop, and P in soil was fractionated chemically by the Hedley method and physically by wet sieving. After 10 years, when P fertilizer was not applied, soil Bray-1 P decreased 50 % respect to the initial P values, and increased up to 2.3 times when evaluating the highest P fertilizer rate. P fertilization did not change in POM-P. P soil labile (NaHCO3-Pi) and moderately labile (NaOH- Pi and HCl 1 M- Pi) inorganic fractions increased 83 %, 50 %, and 22 % in response to P addition, representing an increase of 4.2, 4.9, and 4.5 mg kg−1 of these fractions per 100 kg of applied P. Likewise, these fractions were related with P uptake in the maize test crop with 1.6, 1.5, and 1 kg of P uptake ha−1 in mg kg−1 increase in each of these fractions, respectively. Then, these fractions may be responsible for the legacy-P after 10 years of continuous fertilization in a Luvic Phaeozem of the Pampas region.EEA OliverosFil: Biassoni, María Micaela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; ArgentinaFil: Biassoni, María Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Biassoni, María Micaela. Universidad Nacional de Rosario. Facultad de Ciencias Agrarias. Cátedra de Edafología; ArgentinaFil: Vivas, H. Actividad privada; ArgentinaFil: Gutiérrez Boem, Flavio Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gutiérrez Boem, Flavio Hernán. Universidad de Buenos Aires. Facultad de Agronomía. Cátedra de Fertilidad y Fertilizantes; Argentina.Fil: Salvagiotti, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; ArgentinaFil: Salvagiotti, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Search for axioelectric effect of solar axions using BGO scintillating bolometer
No full textA search for axioelectric absorption of solar axions produced in the (Formula presented.) reaction has been performed with a BGO detector placed in a low-background setup. A model-independent limit on the combination of axion-nucleon and axion-electron coupling constants has been obtained: (Formula presented.) for 90 % confidence level. The constraint of the axion-electron coupling constant has been obtained for hadronic axion with masses of (0.1-1) MeV: (Formula presented.). © 2014 The Author(s)
Development of antibody technology to identify natural killer cell surface antigens in Xenopus Laevis
No full textNatural killer (NK)-like lymphocytes have recently been identified in thymectomised (Tx) Xenopus which are capable of spontaneous cytotoxicity towards the MHC- deficient, allogeneic thymus tumour cell line B(_3)B(_7). This Thesis describes attempts to raise antibodies to Xenopus NK cell surface antigens by phage display and hybridoma technology. The phage display technique was optimised for raising antibodies to novel, cellular antigens in a trial run using the Xenopus thymus tumour cell line B(_3)B(_7). Having isolated a phage antibody which was shown by flow cytometry to bind B(_3)B(_7) cells, the technique was then used to try and raise antibodies to Xenopus NK cells. Isolation of an NIC-specific phage antibody was not achieved but phage antibody XL-6 was raised, which bound an antigen on Xenopus lymphocytes. Phage antibody XL-6, and soluble scFv derived from this, were able to identify a putative mature T cell population in the thymus and may be specific for an amphibian homologue of the mammalian leukocyte common antigen CD45. Hybridoma technology was used to isolate three monoclonal antibodies, 1F8, 4D4 and 1G5, which were shown by flow cytometric analysis to identify a putative NK cell population in control and Tx Xenopus. Following immunomagnetic purification, 1F8- positive spleen cells from control and Tx animals were shown to kill the MHC- deficient tumour target B(_3)B(_7), confirming that this antibody was specific for Xenopus NK cells. Western blotting experiments showed that 1F8, 4D4 and 1G5 identified a doublet of protein bands at 72 and 74 kilodaltons in Xenopus gut lymphoid lysates. Initial attempts to isolate cDNA encoding a Xenopus NK cell surface antigen through immunoscreening a xenopus gut cDNA expression library with antibody 1G5 were unsuccessful as was an attempt to clone a Xenopus homologue of the mammalian NK receptor NKR-Pl by PGR
CUORE
No full textPhysicists have searched for Neutrinoless Double Beta Decay (0vββ) for about a half a century. Developed over the latest 20 years, the bolometric technique is today used by one of the most competitive experimentsin the field: CUORE, a ton-size detector aiming for a sensitivity of ∼1026 yr on 130Te 0vββ decay half-life. With the final step of its construction nearly completed, CUORE will start its operation by the end of the current year. Meanwhile, the first CUORE-like tower is operated at Laboratori Nazionali del Gran Sasso as an independent 0vββ experiment. Named CUORE-0, it represents the state of the art for large-mass, low-background, ultra-lowtemperature bolometer arrays. Besides being a competitive 0vββ decay search, it has validated the ultraclean assembly techniques and radiopurity of materials for the upcoming CUORE experiment. Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence
Pediatric high-grade gliomas and the WHO CNS Tumor Classification - Perspectives of pediatric neuro-oncologists and neuropathologists in light of recent updates
No full text\ua9 2022 The Author(s). Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.Background: The WHO Classification of Tumors of the Central Nervous System has undergone major restructuring. Molecularly defined diagnostic criteria were introduced in 2016 (revised 4th edition) and expanded in 2021 (5th edition) to incorporate further essential diagnostic molecular parameters. We investigated potential differences between specialists in perception of these molecularly defined subtypes for pediatric high-grade gliomas (pedHGG). Methods: We designed a 22-question survey studying the impact of the revised 4th edition of the WHO classification on pedHGG. Data were collected and statistically analyzed to examine the spectrum of viewpoints and possible differences between neuro-oncologists and neuropathologists. Results: 465 participants from 53 countries were included; 187 pediatric neuro-oncologists (40%), 160 neuropathologists (34%), and 118 additional experts (26%). Neuro-oncologists reported issues with the introduction of molecularly defined tumor types, as well as the abolishment or renaming of established tumor entities, while neuropathologists did not to the same extent. Both groups indicated less relevant or insufficient diagnostic definitions were available in 2016. Reported issues were classified and assessed in the 2021 WHO classification and a substantial improvement was perceived. However, issues of high clinical relevance remain to be addressed, including the definition of clinical phenotypes for diffuse intrinsic pontine glioma and gliomatosis cerebri. Conclusions: Within the WHO classification of pediatric brain tumors, such as pedHGG, rapid changes in molecular characterization have been introduced. This study highlights the ongoing need for cross talk between pathologist and oncologist to advance the classification of pedHGG subtypes and ensure biological relevance and clinical impact
KATRIN: Status and Prospects for the Neutrino Mass and Beyond
No full textThe Karlsruhe Tritium Neutrino (KATRIN) experiment is designed to measure a
high-precision integral spectrum of the endpoint region of T2 beta decay, with
the primary goal of probing the absolute mass scale of the neutrino. After a
first tritium commissioning campaign in 2018, the experiment has been regularly
running since 2019, and in its first two measurement campaigns has already
achieved a sub-eV sensitivity. After 1000 days of data-taking, KATRIN's design
sensitivity is 0.2 eV at the 90% confidence level. In this white paper we
describe the current status of KATRIN; explore prospects for measuring the
neutrino mass and other physics observables, including sterile neutrinos and
other beyond-Standard-Model hypotheses; and discuss research-and-development
projects that may further improve the KATRIN sensitivity.Comment: Contribution to Snowmass 2021. 70 pages excluding references; 35
figures. Author list updated June 202
Long-baseline neutrino oscillation physics potential of the DUNE experiment: DUNE Collaboration
No full text© 2020, The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. WSU authors: Meyer, H.; Muether, M.; Solomey, N. The complete list includes: Abi, B.; Acciarri, R.; Acero, M.A.; Adamov, G.; Adams, D.; Adinolfi, M.; Ahmad, Z.; Ahmed, J.; Alion, T.; Monsalve, S.A.; Alt, C.; Anderson, J.; Andreopoulos, C.; Andrews, M.P.; Andrianala, F.; Andringa, S.; Ankowski, A.; Antonova, M.; Antusch, S.; Aranda-Fernandez, A.; Ariga, A.; Arnold, L.O.; Arroyave, M.A.; Asaadi, J.; Aurisano, A.; Aushev, V.; Autiero, D.; Azfar, F.; Back, H.; Back, J.J.; Backhouse, C.; Baesso, P.; Bagby, L.; Bajou, R.; Balasubramanian, S.; Baldi, P.; Bambah, B.; Barao, F.; Barenboim, G.; Barker, G.J.; Barkhouse, W.; Barnes, C.; Barr, G.; Monarca, J.B.; Barros, N.; Barrow, J.L.; Bashyal, A.; Basque, V.; Bay, F.; Alba, J.L.B.; Beacom, J.F.; Bechetoille, E.; Behera, B.; Bellantoni, L.; Bellettini, G.; Bellini, V.; Beltramello, O.; Belver, D.; Benekos, N.; Neves, F.B.; Berger, J.; Berkman, S.; Bernardini, P.; Berner, R.M.; Berns, H.; Bertolucci, S.; Betancourt, M.; Bezawada, Y.; Bhattacharjee, M.; Bhuyan, B.; Biagi, S.; Bian, J.; Biassoni, M.; Biery, K.; Bilki, B.; Bishai, M.; Bitadze, A.; Blake, A.; Siffert, B.B.; Blaszczyk, F.D.M.; Blazey, G.C.; Blucher, E.; Boissevain, J.; Bolognesi, S.; Bolton, T.; Bonesini, M.; Bongrand, M.; Bonini, F.; Booth, A.; Booth, C.; Bordoni, S.; Borkum, A.; Boschi, T.; Bostan, N.; Bour, P.; Boyd, S.B.; Boyden, D.; Bracinik, J.; Braga, D.; Brailsford, D.; Brandt, A.; Bremer, J.; Brew, C.; Brianne, E.; Brice, S.J.; Brizzolari, C.; Bromberg, C.; Brooijmans, G.; Brooke, J.; Bross, A.; Brunetti, G.; Buchanan, N.; Budd, H.; Caiulo, D.; Calafiura, P.; Calcutt, J.; Calin, M.; Calvez, S.; Calvo, E.; Camilleri, L.; Caminata, A.; Campanelli, M.; Caratelli, D.; Carini, G.; Carlus, B.; Carniti, P.; Terrazas, I.C.; Carranza, H.; Castillo, A.; Castromonte, C.; Cattadori, C.; Cavalier, F.; Cavanna, F.; Centro, S.; Cerati, G.; Cervelli, A.; Villanueva, A.C.; Chalifour, M.; Chang, C.; Chardonnet, E.; Chatterjee, A.; Chattopadhyay, S.; Chaves, J.; Chen, H.; Chen, M.; Chen, Y.; Cherdack, D.; Chi, C.; Childress, S.; Chiriacescu, A.; Cho, K.; Choubey, S.; Christensen, A.; Christian, D.; Christodoulou, G.; Church, E.; Clarke, P.; Coan, T.E.; Cocco, A.G.; Coelho, J.A.B.; Conley, E.; Conrad, J.M.; Convery, M.; Corwin, L.; Cotte, P.; Cremaldi, L.; Cremonesi, L.; Crespo-Anadón, J.I.; Cristaldo, E.; Cross, R.; Cuesta, C.; Cui, Y.; Cussans, D.; Dabrowski, M.; Motta, H.; Da Silva Peres, L.; David, C.; David, Q.; Davies, G.S.; Davini, S.; Dawson, J.; De, K.; De Almeida, R.M.; Debbins, P.; De Bonis, I.; Decowski, M.P.; de Gouvêa, A.; De Holanda, P.C.; De Icaza Astiz, I.L.; Deisting, A.; De Jong, P.; Delbart, A.; Delepine, D.; Delgado, M.; Dell’Acqua, A.; De Lurgio, P.; de Mello Neto, J.R.T.; DeMuth, D.M.; Dennis, S.; Densham, C.; Deptuch, G.; De Roeck, A.; De Romeri, V.; De Vries, J.J.; Dharmapalan, R.; Dias, M.; Diaz, F.; Díaz, J.S.; Domizio, S.D.; Giulio, L.D.; Ding, P.; Noto, L.D.; Distefano, C.; Diurba, R.; Diwan, M.; Djurcic, Z.; Dokania, N.; Dolinski, M.J.; Domine, L.; Douglas, D.; Drielsma, F.; Duchesneau, D.; Duffy, K.; Dunne, P.; Durkin, T.; Duyang, H.; Dvornikov, O.; Dwyer, D.A.; Dyshkant, A.S.; Eads, M.; Edmunds, D.; Eisch, J.; Emery, S.; Ereditato, A.; Escobar, C.O.; Sanchez, L.E.; Evans, J.J.; Ewart, E.; Ezeribe, A.C.; Fahey, K.; Falcone, A.; Farnese, C.; Farzan, Y.; Felix, J.; Fernandez-Martinez, E.; Menendez, P.F.; Ferraro, F.; Fields, L.; Filkins, A.; Filthaut, F.; Fitzpatrick, R.S.; Flanagan, W.; Fleming, B.; Flight, R.; Fowler, J.; Fox, W.; Franc, J.; Francis, K.; Franco, D.; Freeman, J.; Freestone, J.; Fried, J.; Friedland, A.; Fuess, S.; Furic, I.; Furmanski, A.P.; Gago, A.; Gallagher, H.; Gallego-Ros, A.; Gallice, N.; Galymov, V.; Gamberini, E.; Gamble, T.; Gandhi, R.; Gandrajula, R.; Gao, S.; Garcia-Gamez, D.; García-Peris, M.Á.; Gardiner, S.; Gastler, D.; Ge, G.; Gelli, B.; Gendotti, A.; Gent, S.; Ghorbani-Moghaddam, Z.; Gibin, D.; Gil-Botella, I.; Girerd, C.; Giri, A.K.; Gnani, D.; Gogota, O.; Gold, M.; Gollapinni, S.; Gollwitzer, K.; Gomes, R.A.; Bermeo, L.V.G.; Fajardo, L.S.G.; Gonnella, F.; Gonzalez-Cuevas, J.A.; Goodman, M.C.; Goodwin, O.; Goswami, S.; Gotti, C.; Goudzovski, E.; Grace, C.; Graham, M.; Gramellini, E.; Gran, R.; Granados, E.; Grant, A.; Grant, C.; Gratieri, D.; Green, P.; Green, S.; Greenler, L.; Greenwood, M.; Greer, J.; Griffith, W.C.; Groh, M.; Grudzinski, J.; Grzelak, K.; Gu, W.; Guarino, V.; Guenette, R.; Guglielmi, A.; Guo, B.; Guthikonda, K.K.; Gutierrez, R.; Guzowski, P.; Guzzo, M.M.; Gwon, S.; Habig, A.; Hackenburg, A.; Hadavand, H.; Haenni, R.; Hahn, A.; Haigh, J.; Haiston, J.; Hamernik, T.; Hamilton, P.; Han, J.; Harder, K.; Harris, D.A.; Hartnell, J.; Hasegawa, T.; Hatcher, R.; Hazen, E.; Heavey, A.; Heeger, K.M.; Heise, J.; Hennessy, K.; Henry, S.; Morquecho, M.A.H.; Herner, K.; Hertel, L.; Hesam, A.S.; Hewes, J.; Higuera, A.; Hill, T.; Hillier, S.J.; Himmel, A.; Hoff, J.; Hohl, C.; Holin, A.; Hoppe, E.; Horton-Smith, G.A.; Hostert, M.; Hourlier, A.; Howard, B.; Howell, R.; Huang, J.; Huang, J.; Hugon, J.; Iles, G.; Ilic, N.; Iliescu, A.M.; Illingworth, R.; Ioannisian, A.; Itay, R.; Izmaylov, A.; James, E.; Jargowsky, B.; Jediny, F.; Jesùs-Valls, C.; Ji, X.; Jiang, L.; Jiménez, S.; Jipa, A.; Joglekar, A.; Johnson, C.; Johnson, R.; Jones, B.; Jones, S.; Jung, C.K.; Junk, T.; Jwa, Y.; Kabirnezhad, M.; Kaboth, A.; Kadenko, I.; Kamiya, F.; Karagiorgi, G.; Karcher, A.; Karolak, M.; Karyotakis, Y.; Kasai, S.; Kasetti, S.P.; Kashur, L.; Kazaryan, N.; Kearns, E.; Keener, P.; Kelly, K.J.; Kemp, E.; Ketchum, W.; Kettell, S.H.; Khabibullin, M.; Khotjantsev, A.; Khvedelidze, A.; Kim, D.; King, B.; Kirby, B.; Kirby, M.; Klein, J.; Koehler, K.; Koerner, L.W.; Kohn, S.; Koller, P.P.; Kordosky, M.; Kosc, T.; Kose, U.; Kostelecký, V.A.; Kothekar, K.; Krennrich, F.; Kreslo, I.; Kudenko, Y.; Kudryavtsev, V.A.; Kulagin, S.; Kumar, J.; Kumar, R.; Kuruppu, C.; Kus, V.; Kutter, T.; Lambert, A.; Lande, K.; Lane, C.E.; Lang, K.; Langford, T.; Lasorak, P.; Last, D.; Lastoria, C.; Laundrie, A.; Lawrence, A.; Lazanu, I.; LaZur, R.; Le, T.; Learned, J.; LeBrun, P.; Miotto, G.L.; Lehnert, R.; de Oliveira, M.A.L.; Leitner, M.; Leyton, M.; Li, L.; Li, S.; Li, S.W.; Li, T.; Li, Y.; Liao, H.; Lin, C.S.; Lin, S.; Lister, A.; Littlejohn, B.R.; Liu, J.; Lockwitz, S.; Loew, T.; Lokajicek, M.; Lomidze, I.; Long, K.; Loo, K.; Lorca, D.; Lord, T.; LoSecco, J.M.; Louis, W.C.; Luk, K.B.; Luo, X.; Lurkin, N.; Lux, T.; Luzio, V.P.; MacFarland, D.; Machado, A.A.; Machado, P.; Macias, C.T.; Macier, J.R.; Maddalena, A.; Madigan, P.; Magill, S.; Mahn, K.; Maio, A.; Maloney, J.A.; Mandrioli, G.; Maneira, J.; Manenti, L.; Manly, S.; Mann, A.; Manolopoulos, K.; Plata, M.M.; Marchionni, A.; Marciano, W.; Marfatia, D.; Mariani, C.; Maricic, J.; Marinho, F.; Marino, A.D.; Marshak, M.; Marshall, C.; Marshall, J.; Marteau, J.; Martin-Albo, J.; Martinez, N.; Caicedo, D.A.M.; Martynenko, S.; Mason, K.; Mastbaum, A.; Masud, M.; Matsuno, S.; Matthews, J.; Mauger, C.; Mauri, N.; Mavrokoridis, K.; Mazza, R.; Mazzacane, A.; Mazzucato, E.; McCluskey, E.; McConkey, N.; McFarland, K.S.; McGrew, C.; McNab, A.; Mefodiev, A.; Mehta, P.; Melas, P.; Mellinato, M.; Mena, O.; Menary, S.; Mendez, H.; Menegolli, A.; Meng, G.; Messier, M.D.; Metcalf, W.; Mewes, M.; Meyer, H.; Miao, T.; Michna, G.; Miedema, T.; Migenda, J.; Milincic, R.; Miller, W.; Mills, J.; Milne, C.; Mineev, O.; Miranda, O.G.; Miryala, S.; Mishra, C.S.; Mishra, S.R.; Mislivec, A.; Mladenov, D.; Mocioiu, I.; Moffat, K.; Moggi, N.; Mohanta, R.; Mohayai, T.A.; Mokhov, N.; Molina, J.; Bueno, L.M.; Montanari, A.; Montanari, C.; Montanari, D.; Zetina, L.M.M.; Moon, J.; Mooney, M.; Moor, A.; Moreno, D.; Morgan, B.; Morris, C.; Mossey, C.; Motuk, E.; Moura, C.A.; Mousseau, J.; Mu, W.; Mualem, L.; Mueller, J.; Muether, M.; Mufson, S.; Muheim, F.; Muir, A.; Mulhearn, M.; Muramatsu, H.; Murphy, S.; Musser, J.; Nachtman, J.; Nagu, S.; Nalbandyan, M.; Nandakumar, R.; Naples, D.; Narita, S.; Navas-Nicolás, D.; Nayak, N.; Nebot-Guinot, M.; Necib, L.; Negishi, K.; Nelson, J.K.; Nesbit, J.; Nessi, M.; Newbold, D.; Newcomer, M.; Newhart, D.; Nichol, R.; Niner, E.; Nishimura, K.; Norman, A.; Norrick, A.; Northrop, R.; Novella, P.; Nowak, J.A.; Oberling, M.; Campo, A.O.D.; Olivier, A.; Onel, Y.; Onishchuk, Y.; Ott, J.; Pagani, L.; Pakvasa, S.; Palamara, O.; Palestini, S.; Paley, J.M.; Pallavicini, M.; Palomares, C.; Pantic, E.; Paolone, V.; Papadimitriou, V.; Papaleo, R.; Papanestis, A.; Paramesvaran, S.; Parke, S.; Parsa, Z.; Parvu, M.; Pascoli, S.; Pasqualini, L.; Pasternak, J.; Pater, J.; Patrick, C.; Patrizii, L.; Patterson, R.B.; Patton, S.J.; Patzak, T.; Paudel, A.; Paulos, B.; Paulucci, L.; Pavlovic, Z.; Pawloski, G.; Payne, D.; Pec, V.; Peeters, S.J.M.; Penichot, Y.; Pennacchio, E.; Penzo, A.; Peres, O.L.G.; Perry, J.; Pershey, D.; Pessina, G.; Petrillo, G.; Petta, C.; Petti, R.; Piastra, F.; Pickering, L.; Pietropaolo, F.; Pillow, J.; Pinzino, J.; Plunkett, R.; Poling, R.; Pons, X.; • Poonthottathil, N.; Pordes, S.; Potekhin, M.; Potenza, R.; Potukuchi, B.V.K.S.; Pozimski, J.; Pozzato, M.; Prakash, S.; Prakash, T.; Prince, S.; Prior, G.; Pugnere, D.; Qi, K.; Qian, X.; Raaf, J.L.; Raboanary, R.; Radeka, V.; Rademacker, J.; Radics, B.; Rafique, A.; Raguzin, E.; Rai, M.; Rajaoalisoa, M.; Rakhno, I.; Rakotondramanana, H.T.; Rakotondravohitra, L.; Ramachers, Y.A.; Rameika, R.; Delgado, M.A.R.; Ramson, B.; Rappoldi, A.; Raselli, G.; Ratoff, P.; Ravat, S.; Razafinime, H.; Real, J.S.; Rebel, B.; Redondo, D.; Reggiani-Guzzo, M.; Rehak, T.; Reichenbacher, J.; Reitzner, S.D.; Renshaw, A.; Rescia, S.; Resnati, F.; Reynolds, A.; Riccobene, G.; Rice, L.C.J.; Rielage, K.; Rigaut, Y.; Rivera, D.; Rochester, L.; Roda, M.; Rodrigues, P.; Alonso, M.J.R.; Rondon, J.R.; Roeth, A.J.; Rogers, H.; Rosauro-Alcaraz, S.; Rossella, M.; Rout, J.; Roy, S.; Rubbia, A.; Rubbia, C.; Russell, B.; Russell, J.; Ruterbories, D.; Saakyan, R.; Sacerdoti, S.; Safford, T.; Sahu, N.; Sala, P.; Samios, N.; Sanchez, M.C.; Sanders, D.A.; Sankey, D.; Santana, S.; Santos-Maldonado, M.; Saoulidou, N.; Sapienza, P.; Sarasty, C.; Sarcevic, I.; Savage, G.; Savinov, V.; Scaramelli, A.; Scarff, A.; Scarpelli, A.; Schaffer, T.; Schellman, H.; Schlabach, P.; Schmitz, D.; Scholberg, K.; Schukraft, A.; Segreto, E.; Sensenig, J.; Seong, I.; Sergi, A.; Sergiampietri, F.; Sgalaberna, D.; Shaevitz, M.H.; Shafaq, S.; Shamma, M.; Sharma, H.R.; Sharma, R.; Shaw, T.; Shepherd-Themistocleous, C.; Shin, S.; Shooltz, D.; Shrock, R.; Simard, L.; Simos, N.; Sinclair, J.; Sinev, G.; Singh, J.; Singh, J.; Singh, V.; Sipos, R.; Sippach, F.W.; Sirri, G.; Sitraka, A.; Siyeon, K.; Smargianaki, D.; Smith, A.; Smith, A.; Smith, E.; Smith, P.; Smolik, J.; Smy, M.; Snopok, P.; Nunes, M.S.; Sobel, H.; Soderberg, M.; Salinas, C.J.S.; Söldner-Rembold, S.; Solomey, N.; Solovov, V.; Sondheim, W.E.; Sorel, M.; Soto-Oton, J.; Sousa, A.; Soustruznik, K.; Spagliardi, F.; Spanu, M.; Spitz, J.; Spooner, N.J.C.; Spurgeon, K.; Staley, R.; Stancari, M.; Stanco, L.; Steiner, H.M.; Stewart, J.; Stillwell, B.; Stock, J.; Stocker, F.; Stokes, T.; Strait, M.; Strauss, T.; Striganov, S.; Stuart, A.; Summers, D.; Surdo, A.; Susic, V.; Suter, L.; Sutera, C.M.; Svoboda, R.; Szczerbinska, B.; Szelc, A.M.; Talaga, R.; Tanaka, H.A.; Oregui, B.T.; Tapper, A.; Tariq, S.; Tatar, E.; Tayloe, R.; Teklu, A.M.; Tenti, M.; Terao, K.; Ternes, C.A.; Terranova, F.; Testera, G.; Thea, A.; Thompson, J.L.; Thorn, C.; Timm, S.C.; Tonazzo, A.; Torti, M.; Tortola, M.; Tortorici, F.; Totani, D.; Toups, M.; Touramanis, C.; Trevor, J.; Trzaska, W.H.; Tsai, Y.T.; Tsamalaidze, Z.; Tsang, K.V.; Tsverava, N.; Tufanli, S.; Tull, C.; Tyley, E.; Tzanov, M.; Uchida, M.A.; Urheim, J.; Usher, T.; Vagins, M.R.; Vahle, P.; Valdiviesso, G.A.; Valencia, E.; Vallari, Z.; Valle, J.W.F.; Vallecorsa, S.; Van Berg, R.; Van de Water, R.G.; Forero, D.V.; Varanini, F.; Vargas, D.; Varner, G.; Vasel, J.; Vasseur, G.; Vaziri, K.; Ventura, S.; Verdugo, A.; Vergani, S.; Vermeulen, M.A.; Verzocchi, M.; de Souza, H.V.; Vignoli, C.; Vilela, C.; Viren, B.; Vrba, T.; Wachala, T.; Waldron, A.V.; Wallbank, M.; Wang, H.; Wang, J.; Wang, Y.; Wang, Y.; Warburton, K.; Warner, D.; Wascko, M.; Waters, D.; Watson, A.; Weatherly, P.; Weber, A.; Weber, M.; Wei, H.; Weinstein, A.; Wenman, D.; Wetstein, M.; While, M.R.; White, A.; Whitehead, L.H.; Whittington, D.; Wilking, M.J.; Wilkinson, C.; Williams, Z.; Wilson, F.; Wilson, R.J.; Wolcott, J.; Wongjirad, T.; Wood, K.; Wood, L.; Worcester, E.; Worcester, M.; Wret, C.; Wu, W.; Wu, W.; Xiao, Y.; Yang, G.; Yang, T.; Yershov, N.; Yonehara, K.; Young, T.; Yu, B.; Yu, J.; Zaki, R.; Zalesak, J.; Zambelli, L.; Zamorano, B.; Zani, A.; Zazueta, L.; Zeller, G.P.; Zennamo, J.; Zeug, K.; Zhang, C.; Zhao, M.; Zhivun, E.; Zhu, G.; Zimmerman, E.D.; Zito, M.; Zucchelli, S.; Zuklin, J.; Zutshi, V.; Zwaska, R.The sensitivity of the Deep Underground Neutrino Experiment (DUNE) to neutrino oscillation is determined, based on a full simulation, reconstruction, and event selection of the far detector and a full simulation and parameterized analysis of the near detector. Detailed uncertainties due to the flux prediction, neutrino interaction model, and detector effects are included. DUNE will resolve the neutrino mass hierarchy to a precision of 5, for all values, after 2 years of running with the nominal detector design and beam configuration. It has the potential to observe charge-parity violation in the neutrino sector to a precision of 3 (5) after an exposure of 5 (10) years, for 50\% of all values. It will also make precise measurements of other parameters governing long-baseline neutrino oscillation, and after an exposure of 15 years will achieve a similar sensitivity to to current reactor experiments.This work was supported by CNPq, FAPERJ, FAPEG and FAPESP, Brazil; CFI, IPP and NSERC, Canada; CERN; MŠMT, Czech Republic; ERDF, H2020-EU and MSCA, European Union; CNRS/IN2P3 and CEA, France; INFN, Italy; FCT, Portugal; NRF, South Korea; CAM, Fundación “La Caixa” and MICINN, Spain; SERI and SNSF, Switzerland; TÜBİTAK, Turkey; The Royal Society and UKRI/STFC, UK; DOE and NSF, United States of America. This research used resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under Contract No. DE-AC02-05CH11231
Supernova neutrino burst detection with the deep underground neutrino experiment: DUNE Collaboration
No full textThe deep underground neutrino experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE’s ability to constrain the νe spectral parameters of the neutrino burst will be considered. © 2021, The Author(s)
Long-term outcome of the Milano-hyperfractionated accelerated radiotherapy strategy for high-risk medulloblastoma, including the impact of molecular subtype
No full text\ua9 The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. Background. We applied the strategy for M+ medulloblastoma across all high-risk subgroups, including LC/A histology, TP53 mutations, and MYC/MYCN amplification. Methods. Patients over 3 years old received, after surgery, staging and histo-biological analysis, sequential high-dose-methotrexate(HD-MTX), high-dose-etoposide(HD-VP16), high-dose-cyclophosphamide(HD-Cyclo), and high-dose-carboplatin(HD-Carbo). Hyperfractionated-accelerated-radiotherapy–craniospinal(HART-CSI), administered twice daily 1.3 Gy-fractions reached a total dose tailored to the patients’ age and pre-radiation response to chemotherapy(CT): 31.2 Gy if under 10-years-old and complete response(CR) or partial response(PR) obtained or absence of metastatic disease, 39 Gy in other/older patients. Boosts to posterior fossa/residual metastatic(M+) deposits were given up to a total dose of 60 Gy/9 Gy, respectively, but avoided if metastatic nodules were very big or patients were very young. Two courses of high-dose-thiotepa were delivered in case of not CR/PR after the pre-radiotherapy (RT) phase and in all M0 patients either—pre/post-HART. Subgrouping was performed where the tissue was available. Results. Eighty-nine patients were enrolled, with a median age of 8.8 years, and a median follow-up of 136 months. Overall survival (OS) and event-free survival (EFS) at 5/15 years were 75.9/66.5% and 68.2/65.3%, respectively; 5/28 fatal events were not related to relapse(3 developed secondary malignancies). Sex, age less than 10 years, histological subtype, presence of MYC/MYCN amplification, reduction in CSI dose, omission of RT-boosts, implementation of myeloablative therapy, presence–absence of metastases did not impact prognosis.Patients progressing after pre-HART CT(14/89) and stable-disease(SD)+PD after HART(10/89) negatively affected outcome(P < .001).Subgrouping in 66/89 patients’ samples demonstrated a significantly worse EFS for patients with Sonic Hedgehog(SHH)-tumors(#15, 2 with constitutional TP53-mutations) versus groups 3 and 4(15 and 29 patients, respectively, group3/4 in 7).Patients younger than 10 received lower CSI doses if stratified according to CT response. Conclusions. This strategy, partly adopted in the ongoing SIOPE protocol, confirmed improved EFS and OS over previously reported outcomes in all high-risk categories; SHH tumors appeared the most aggressive
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The commissioning of the CUORE experiment: The mini-tower run
No full text© Copyright owned by the author(s). CUORE is a ton-scale experiment approaching the data taking phase in Gran Sasso National Laboratory. Its primary goal is to search for the neutrinoless double-beta decay in130Te using 988 crystals of tellurim dioxide. The crystals are operated as bolometers at about 10 mK taking advantage of one of the largest dilution cryostat ever built. Concluded in March 2016, the cryostat commissioning consisted in a sequence of cool down runs each one integrating new parts of the apparatus. The last run was performed with the fully configured cryostat and the thermal load at 4 K reached the impressive mass of about 14 tons. During that run the base temperature of 6.3 mK was reached and maintained for more than 70 days. An array of 8 crystals, called mini-tower, was used to check bolometers operation, readout electronics and DAQ. Results will be presented in terms of cooling power, electronic noise, energy resolution and preliminary background measurements
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