1,835 research outputs found
Opere del conte Algarotti.
No full textIncludes index in vol. 7.Added t.p. in vol. 1, engraved by Giuseppe Patrini. Engraved portrait medallion of the author on t.p. in vol. 1, small woodcut title-vignettes on title pages in vol. 2-10.Mode of access: Internet
A mortalin-like gene is crucial for planarian stem cell viability
No full textIn adult organisms, stem cells are crucial to homeostasis and regeneration of damaged tissues. In planarians,
adult stem cells (neoblasts) are endowed with an extraordinary replicative potential that guarantees
unlimited replacement of all differentiated cell types and extraordinary regenerative ability. The molecular
mechanisms by which neoblasts combine long-term stability and constant proliferative activity, overcoming
the impact of time, remain by far unknown. Here we investigate the role of Djmot, a planarian orthologue
that encodes a peculiar member of the HSP70 family, named Mortalin, on the dynamics of stem cells of
Dugesia japonica. Planarian stem cells and progenitors constitutively express Djmot. Transient Djmot
expression in differentiated tissues is only observed after X-ray irradiation. DjmotRNA interference causes
inability to regenerate and death of the animals, as a result of permanent growth arrest of stem cells. These
results provide the first evidence that an hsp-related gene is essential for neoblast viability and suggest the
possibility that high levels of Djmot serve to keep a p53-like protein signaling under control, thus allowing
neoblasts to escape cell death programs. Further studies are needed to unravel the molecular pathways
involved in these processes
Inert monolithic device with a central hole for constant drug release
No full textIn vitro drug release from inert monolithic matrices is generally characterized by a non-linear profile. This paper examines the release of drugs from a heterogeneous insoluble matrix which was designed to obtain an in vitro constant release. This matrix system, which shows a special geometry, consists of a biconvex perforated inert core that is partially covered with a water impermeable polymeric film so that the inner hole surface is the only releasing surface. Both the tabletting of perforated cores and their partial coating can be performed under continuous operating processes. This makes the system suitable for industrial applications thus differentiating it from all previous geometry-based inert systems. The release rate from this kind of device proved to be constant, irrespective of drug solubility, at up to 80% of delivery
Expression of hsp90 mediates cytoprotective effects in the gastrodermis of planarians
No full textHeat shock proteins (HSPs) play a crucial role in the protection of cells. In the present study, we have identified an hsp90-related gene (Djhsp90) encoding a cytosolic form of HSP90 that is primarily expressed in gastrodermis of the planarian Dugesia japonica. Djhsp90 becomes significantly induced after traumatic amputation or other stress stimuli, such as exposure to X-ray or ultraviolet radiations, heat shock, or prolonged starvation. When Djhsp90 is silenced by ribonucleic acid interference (RNAi), planarians dramatically decrease in size, becoming unable to eat, and die in a few weeks. Our results indicate that this gene plays an essential cytoprotective role in the gastrodermis of planarians and suggest that this chaperone can be involved in autophagic processes that are activated by this tissue
Characterization of hsp genes on planarian stem cells
No full textPlanarians are a model system known for regenerative potential, body plasticity and continuous turnover of all differentiated cell types. These characteristics are based on the presence of pluripotent stem cells, called neoblasts. Damage or reduction in the number of neoblasts deeply affects planarian regeneration and survival. Heat shock proteins (HSPs) are known to perform essential cytoprotective functions in all organisms. To investigate the potential role of hsp-related genes on the dynamics of planarian stem cells, representative hsp-related genes were identified and characterized in normal conditions and after different stress stimuli. Our work revealed that two different hsp genes (Djhsp60 and Djmot) are constitutively expressed in neoblasts, suggesting that their products play important roles in cytoprotection of these cells. RNAi-based functional studies provide evidence of an involvement of Djhsp60 and Djmot in the adaptive response of planarian stem cells to stress and indicate that expression of these genes is critical for planarian survival
Antimicrobial protection of cosmetic formulations: a novel approach based on polymeric releasing matrices
No full textThe hidden author: an interpretation of Petronius' Satyricon
No full textThe Satyricon of Petronius, a comic novel written in the first century A.D., is famous today primarily for its amazing banquet tale, "Trimalchio's Feast." But this episode is only one part of the larger picture of life during Nero's rule presented in the work. In this accessible discussion of Petronius's masterful use of parody, Gian Biagio Conte offers an interpretation of the Satyricon as a whole. He combines the scholarly precision of close reading with a significant, original theoretical model.At the heart of his interpretation, Conte reveals the technique of the "hidden author" that Petronius employs at the expense of his characters, in particular the teller of the story, Enclopius. By remaining hidden outside the narrative, Petronius invites the reader to smile at the folies de grandeur that occur in a culture of scholars and declaimers. Yet as Conte shows, behind the parody and inexhaustible humor of the Satyricon lies an unexpectedly serious lament. For those familiar with the Satyricon, as well as for new readers, Conte's book will be a reliable, enjoyable guide to the wonders the Satyricon contains
Le prime imprese del conte Orlando /
No full textSignatures: *⁸ A-M⁸ N¹⁰.Giolitto's device on t.p. (phoenix). Port. of the author within architectural border incorporating coats of arms, *8v. Each of the 25 cantos is preceded by an "argomento" in verse, an "allegoria" in prose, and a woodcut ill. (repeats). The "argomenti" and the ill. appear within elaborate decorative borders. Two of the border elements depict cities and include the initial P. Head and tail pieces, historiated and foliated initials, fleurons.Mode of access: Internet.At upper left-hand corner of front pastedown is calligraphic label of Theodore Besterman, signed with the initials P.S.Binding: calf mottled red and brown, rebacked and repaired. Triple gilt fillets along edges of boards. Spine title in gilt: DOLCE / ORLANDO. Page edges blue
Il lessico politico negli «Ammaestramenti degli antichi» di Bartolomeo da San Concordio
No full textThe vernacular translation of the Documenta antiquorum by Bartolomew of Santo Concordio represents a rare testimony of an auto-translation performed in Florence between the 13th and the 14th centuries. The very coincidence of the author and the translator in the same person reveals the programmatic character of the drafting of this text in vulgar, and the connection with the choice for an opening to the Tuscan vernacular of such a moral and edifying work, and as part of the project of diffusion and circulation of moral thought, intentionally undertaken by the mendicant Orders. Through a conceptual comparison with the contemporary political treaties by Remigio de’ Girolami and Tolomeo da Lucca, and the linguistic analysis of the translation choices in the semantic field of politics (compared with the vulgar translation of Sallustius and the works of the most important vulgar translators of the Duecento), the article observes that in the Ammaestramenti degli Antichi the main concern is towards actualization. The translation wants to display the classical world and the religious examples as a mirror of the Italian municipal society. To achieve this objective, the author needs to create a context that is readily intelligible and immediately recognizable by the reader, whether he is a cleric or a layman
Erodible perforated coated matrix for extended release of drugs
No full textA new oral modified release system exibiting an in vitro constant release rate has been designed and prepared. The system consists of an erodible matrix core with a central hole and is partially covered with an impermeable polymeric film. The perforated core is made of a low viscosity hydroxypropylmethylcellulose (HPMC); metoprolol tartrate and benfluorex were used as model drugs. The inner hole surface is the only releasing surface of the system. This system can be prepared by using both conventional tabletting and film coating processes
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