1,554 research outputs found
Reversal of doxorubicin and cisplatin resistance in vivo in murine leukemias by the calcium antagonist RO 11-2933
No full textThe ability of RO 11-2933 to modulate in vivo Doxorubicin and Cisplatin antitumor activity has been evaluated in sensitive and resistant P388 and L1210 murine leukemias. A reversal of both Doxorubicin or Cisplatin resistance has been observed when P388/Dx or L1210/CP tumor bearing mice received multiple treatments of the antitumor agent plus 30 mg/Kg of RO 11-2933. No modification of Doxorubicin or Cisplatin effect has been observed in sensitive tumors. The results obtained indicate that RO 11-2933 might represent a promising agent for the reversal of multidrug resistance
Firms, Industries, Markets. Micro, Meso, and Macro Relationships in the Economics of Complexity
No full textThis book offers a rigorous discussion on how we can understand economic systems through a complexity lens. In particular, the author investigates the relationships between the firms, the industries, and markets (micro, meso, macro relationships), in order to help us better understand the main challenges of a representation of the economy using the “complex systems’ theory”. The author argues that the logic of governance in the paradigm of complex systemic rationality renounces anthropocentric vision of the organization and the possibility of total direction and control over systemic and intersystemic relations and accept a constructivist vision of these relations and their mutual interdependencies. Offering a novel perspective, this book contributes to improve our understanding of economic complex systems and how organizations at different levels interact
Review: Cristina Mazzoni: She-Wolf. The Story of a Roman Icon. Cambridge University Press, New York 2010
No full textProfessor Cristina Mazzoni of the University of Vermont has written the first comprehensive study of the Roman she-wolf. This is a wide-ranging book in which this author illustrates various roles of the she-wolf by analyzing paintings, statues, maps, poetry, fiction, and historical narrative from antiquity to contemporary times. "She-Wolf. The Story of a Roman Icon" is a vividly written book, which skillfully combines diverse sources and standpoints into a coherent and readable study. The black-and-white photographs, some of which were taken by the author herself, support the text and illustrate the diversity of the visual representations of the she-wolf across the centuries.nonPeerReviewe
Premio AUTeC per la migliore Tesi di Dottorato in Cartografia e Topografia
No full textThis is the result of three years of work and research around GNSS permanent stations and
Networks, GNSS data processing and GNSS surveys technics and methodologies for several
applications.
It is possible to associate the main field of the research to the two main goals of GNSS
Networks: Realize a Reference system and distribute it to the users community.
Earth surface is continuously changing due to several phenomena, which may be
distinguished in periodic and irreversible phenomena.
With respect to periodic phenomena a mean position of a point on Earth surface can be
defined. With respect to irreversible phenomena each point occupies a specific position just
for an infinitesimal instant: estimated coordinates of a point (spatial referencing) must be also
time referenced.
A Reference System (RS) is, at first, defined by mathematical/physical laws rules. Then, a
realization (Reference Frame, RF) follows, by physical and geometrical measurements.
Terrestrial reference systems are needed to georeference the positions of points located on the
Earth. They can be distinguished in:
· Global Reference Systems
They are defined on the whole planet and realized by global networks of fundamental
points. Fundamental points coordinates are estimated by spatial geodesy techniques.
· Local Reference Systems
They are defined at the local scale (continental or regional) and realized by
subnetworks of fundamental points. Fundamental points coordinates are estimated by
terrestrial geodesy techniques. In this category is possible to mention the ED1950 (for
Europe) and ROMA1940 (for Italy).
Local reference systems, since they born before spatial geodesy, are nowadays decreasing of
importance in terms of points georeferencing, but they still have historical significance and
are used in cartographic applications.
After the birth of spacial geodesy, like GNSS (Global Navigation Satellite System), it was
possible to define and realize global reference systems. The nodal point of this innovation is
the realization of the global reference system by GNSS permanent stations networks.
During the Ph.D. activities a deep analysis of global reference systems research was carried
out. In particular, GNSS data processing techniques and skills were acquired. This aspect of
the research achieved the goal with the author involvement, as Geodesy and Geomatics
Group member, into the realization by the Italian Military Geographic Institute (IGM) of the
European Reference System in Italy. The switch form the old static realization (IGM95) to a
GNSS permanent station based realization was made official and published by IGM in
February 2009 with the National Dynamic Network (RDN) presentation: 100 GNSS
permanent stations homogenously distributed in the Italian Country.
Also the official permanent station of the La Sapienza Rome University, M0SE, of which
maintenance and inclusion in the European Permanent networ
Prefazione all'edizione italiana di "Il bambino e la coppia"
No full textL'Autrice connette il lavoro di Fivaz Depeursinge e Philipp agli studi di P. Minuchin sull'evoluzione del bambino nell'ambito delle relazioni familiari. Viene inoltre proposta una riflessione sull'utilità del volume nell'ambito della terapia familiare che coinvolge i bambini. Il ruolo attivo del bambino nel triangolo primario viene connesso a specifici disturbi per i quali può essere richiesto un aiuto psicoterapeutico dai genitori.The author connects the work of Fivaz Depeursinge and Philipp to the studies of P. Minuchin about evolution of the child in the context of family relationships. It also proposed a reflection on the usefulness of the book in the context of family therapy involving children. The active role of the child in primary triangle is connected to specific conditions for which may be required psychotherapeutic help from parents
Autobiographical memories and beliefs: A preliminary metacognitive model
No full textReturning a rented car, the authors of this chapter tried to remember whose credit card had been imprinted when the car had been picked up. After some thought, the senior author reported a clear memory of giving the rental agent her card, and the junior author concurred that this had happened. Despite this clear shared memory, it was the junior author's card that had been imprinted.
People's memories and beliefs about events that may have happened to them can be true or false, and the consequences of being wrong are often more severe than those in the incident described above. Married couples argue about their divergent memories of past events, politicians are embarrassed when they misremember events that are a matter of popular record, and families can be destroyed when psychotherapy clients develop false memories of childhood abuse. The central thesis of this chapter is that the answers people give to questions regarding the occurrence of events in their life are based on metacognitive decisional mechanisms. These mechanisms take two factors into account:(a) the information that is available about the event at the moment of the decision; and (b) the metacognitive beliefs that people hold. We maintain that the same decisional mechanisms and metacognitive beliefs that play a role when people have to answer questions about the occurrence of events that actually happened are also involved when people develop false beliefs and memories for events that did not happen to them. We begin by drawing a distinction between false autobiographical beliefs and false autobiographical memories. Next, the role of metacognitive belief
Exploiting high-resolution data to investigate the characteristics of water consumption at the end-use level: A Dutch case study
No full textIn the water industry, an accurate estimation of end-use water consumption is helpful for the implementation of efficient water systems and water-saving technologies. This study aimed to explore the characteristics of water consumption at nine households north of Amsterdam (the Netherlands), subjected to water consumption monitoring at high temporal resolution (i.e. 1 s). Overall, 36,297 water-use events monitored over about 447 days were automatically segmented into 44,115 individual events by means of a new rule-based filtering algorithm, and then labelled by expert analysts. A multi-stage analysis was then conducted in order to evaluate daily per capita end-use water consumption, daily end-use profiles, average end-use parameter average, and their statistical distributions. The results achieved provide insight into the features of end-use consumption, confirming that the largest components are typically related to showers/bathtubs, toilets, and washing machines, whereas different end-use parameter distributions can emerge.Sanitary Engineerin
Effects of misleading questions and hypnotic memory suggestion on memory reports: A signal-detection analysis
No full textIn 2002, the first author and collegues reported data indicating that both hypnosis and misleading questions decreased the accuracy of memory reports and decreased "don't know" response rates, that the effects of misleading questions were significantly greater than those of hypnosis, and that the two effects were additive. Using a sample of 194 undergraduate students, the present study replicated the findings that misleading questions reduce accuracy and "don't know" responding but failed to replicate the negative effect of hypnosis on memory reports. Signal detection analysis indicated that misleading questioning produced decreased sensitivity accompanied by higher response bias, though affecting sensitivity more than producing a criterion shift. Copyright © International Journal of Clinical and Experimental Hypnosis
Polyglycolic acid–polylactic acid scaffold response to different progenitor cell in vitro cultures : a demonstrative and comparative x-ray synchrotron radiation phase-contrast microtomography study
Get PDFSpatiotemporal interactions play important roles in tissue development and function, especially in stem cell-seeded bioscaffolds. Cells interact with the surface of bioscaffold polymers and influence material-driven control of cell differentiation. In vitro cultures of different human progenitor cells, i.e. endothelial colony-forming cells (ECFCs) from a healthy control and a patient with Kaposi sarcoma (an angioproliferative disease) and human CD133+ muscle-derived stem cells (MSH 133+ cells), were seeded onto polyglycolic acid–polylactic acid scaffolds. 3D images were obtained by X-ray phase-contrast microtomography (micro-CT) and processed with the Modified Bronnikov Algorithm. The method enabled high spatial resolution detection of the 3D structural organization of cells on the bioscaffold and evaluation of the way and rate at which cells modified the construct at different time points from seeding. The different cell types displayed significant differences in proliferation rate. In conclusion, X-ray synchrotron radiation phase-contrast micro-CT analysis proved to be a useful and sensitive tool to investigate the spatiotemporal pattern of progenitor cell organization on a bioscaffold
Electrical Systems for Nuclear Power Plants
No full textBased on author Omar Mazzoni\u27s notes for a graduate level course he taught in Electrical Engineering, this book discusses all aspects of electrical systems for nuclear power plants, making reference to IEEE nuclear standards and regulatory documents. It covers such important topics as the requirements for equipment qualification, acceptance testing, periodic surveillance, and operational issues. It also provides excellent guidance for students in understanding the basis of nuclear plant electrical systems, the industry standards that are applicable, and the Nuclear Regulatory Commission\u27s rules for designing and operating nuclear plants.
Electrical Systems for Nuclear Power Plants offers in-depth chapters covering: elements of a power system; special regulations and requirements; unique requirements of a Class 1E power system; nuclear plants containment electrical penetration assemblies; on-site emergency AC sources; on-site emergency DC sources; protective relaying; interface of the nuclear plant with the grid; station blackout (SBO) issues and regulations; review of electric power calculations; equipment aging and decommissioning; and electrical and control systems inspections
- …
