16,278 research outputs found
EW‐7197 prevents ulcerative colitis‐associated fibrosis and inflammation
No full textEW-7197 is a transforming growth factor-ß type I receptor kinase inhibitor with potential anti-inflammatory and antifibrotic properties. Here, we investigate the potential therapeutic effects of EW-7197 in a murine model of ulcerative colitis. EW-7197 attenuated the colitis disease activity index by improving rectal bleeding, body weight, and degree of stool consistency. EW-7197 also reduced colorectal tissue damage and the colon histopathological score by reducing crypt loss, mucosal damage, and tissue inflammation. Moreover, EW-7197 appeared to ameliorate the inflammatory and fibrotic responses by reducing oxidative stress, reducing submucosal edema and inflammatory cell infiltration, downregulating proinflammatory and pro-fibrotic genes, and inhibiting excessive collagen deposition in inflamed and fibrotic ulcerative colitis tissues. These results suggest that EW-7197 has potentially useful therapeutic properties against colitis, with clinically translational potential of inhibiting key pathological responses of inflammation and fibrosis in patients with colitis
EW-7197 prevents ulcerative colitis-associated fibrosis and inflammation
No full textEW-7197 is a transforming growth factor-ß type I receptor kinase inhibitor with potential anti-inflammatory and antifibrotic properties. Here, we investigate the potential therapeutic effects of EW-7197 in a murine model of ulcerative colitis. EW-7197 attenuated the colitis disease activity index by improving rectal bleeding, body weight, and degree of stool consistency. EW-7197 also reduced colorectal tissue damage and the colon histopathological score by reducing crypt loss, mucosal damage, and tissue inflammation. Moreover, EW-7197 appeared to ameliorate the inflammatory and fibrotic responses by reducing oxidative stress, reducing submucosal edema and inflammatory cell infiltration, downregulating proinflammatory and pro-fibrotic genes, and inhibiting excessive collagen deposition in inflamed and fibrotic ulcerative colitis tissues. These results suggest that EW-7197 has potentially useful therapeutic properties against colitis, with clinically translational potential of inhibiting key pathological responses of inflammation and fibrosis in patients with colitis
Light-time effect in two eclipsing binaries: NO Vul and EW Lyr
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYIn this study, orbital period variations of two eclipsing binary systems (NO Vul and EW Lyr) were discussed. Possible light time effects due to third bodies in these systems were re-examined. The mass function and orbital period of hypothetical third bodies were calculated to be 0.000627 +/- 1.000003 M-circle dot, 26.17 +/- 0.05 years and 0.12682 +/- 0.00003 M-circle dot, 77.23 +/- 0.72 years for NO Vul and EW Lyr, respectively.Turkish Phys So
Exact analytical solutions of the fractional biological population model, fractional EW and modified EW equations
No full textIn this paper, exact analytical solutions of the biological population model, the EW and the modified EW equations with a conformable derivative operator have been examined by means of the trial solution algorithm and the complete discrimination system. Dark, bright and singular traveling wave solutions of the equations have been obtained by algorithm. Also, revealed singular periodic solutions have been listed. All solutions were verified by substituting them into their corresponding equation via Mathematica package program. © 2021 Balikesir University. All rights reserved.The author would like to thank to Ege University, Scientific Research Project (BAP) for the support on the Project 17-TKMYO-002
Logarithmic EW corrections at one-loop
No full textAbstract We present a fully automated implementation of next-to-leading order electroweak (NLO EW) corrections in the logarithmic approximation in OpenLoops. For energies above the electroweak scale NLO EW corrections are logarithmically enhanced and in tails of kinematic distributions of crucial LHC processes yield correction factors of several tens of percent. The implementation of the logarithmic Sudakov EW approximation in the amplitude generator OpenLoops is fully general, largely model independent, it supports the computation of EW corrections to resonant processes, and it is suitable for extensions to the two-loop NNLO EW level. The implementation is based on an efficient representation of the logarithmic approximation in terms of an effective vertex approach. Investigating a set of representative LHC processes we find excellent agreement between the logarithmic approximation and full one-loop results in observables where the assumptions of the EW Sudakov approximation are fulfilled
Dataset references for EW-MFA study on Jura canton
No full textSources for datasets used for EW-MFA project on Jura canton. If a data source is confidential or doesn't have a link, please contact the author
The tumble mode - where test pilots fear to tread
No full textFollowing a fatal accident in 1997 and identification of common patterns in several (usually fatal) previous accidents the AAIB (United Kingdom Air Accidents Investigation Branch) asked the BMAA (British Microlight Aircraft Association) to pursue a course of investigation into the tumble mode, which had been attributed as the primary cause of that fatal accident.
The tumble mode is a peculiarity of weightshift controlled aircraft - that is flexwing microlights and hang-gliders. It is a departure from controlled flight leading to a nose-down pitch autorotation: pitch rates of 400°/s are known. When a tumble occurs in a microlight aeroplane, it is rare for the crew to survive and loss of the aircraft is universal
Magnetic fields and the EW phase transition
No full textLaine M. Magnetic fields and the EW phase transition. In: Ambjørn J, Damgaard PH, Kainulainen K, Rummukainen K, eds. Strong and Electroweak Matter '98, Proceedings of a conference held in Copenhagen, Denmark, 2-5 December. World Scientific Publishers; 1998: 319
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