51,681 research outputs found
Edward C. M. Chen, oral history interview and transcript
No full textThis recording and transcript form part of a collection of oral history interviews conducted by the Chao Center for Asian Studies at Rice University. This collection includes audio recordings and transcripts of interviews with Asian Americans native to Houston.Edward C. M. Chen, interviewed by Juean Chen and Clarissa Cox, June 4, 2010, in Houston, Texas
Cox, C M, NX36980
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/379261Surname: COX
Given Name(s) or Initials: C M
Military Service Number or Last Known Location: NX36980
Missing, Wounded and Prisoner of War Enquiry Card Index Number: 15797193073
Item: [2016.0049.11554] "Cox, C M, NX36980
Selective COX-2 inhibitors and risk of myocardial infarction
No full textSelective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids. Recently some coxibs, which were designed to exploit the advantageous effects of non- steroidal anti-inflammatory drugs while evading their side effects, have been reported to increase the risk of myocardial infarction and atherothrombotic events. This has led to the withdrawal of rofecoxib from global markets, and warnings have been issued by drug authorities about similar events during the use of celecoxib or valdecoxib/ parecoxib, bringing about questions of an inherent atherothrombotic risk of all coxibs and consequences that should be drawn by health care professionals. These questions need to be addressed in light of the known effects of selective inhibition of COX- 2 on the cardiovascular system. Although COX- 2, in contrast to the cyclooxygenase-1 ( COX- 1) isoform, is regarded as an inducible enzyme that only has a role in pathophysiological processes like pain and inflammation, experimental and clinical studies have shown that COX- 2 is constitutively expressed in tissues like the kidney or vascular endothelium, where it executes important physiological functions. COX- 2- dependent formation of prostanoids not only results in the mediation of pain or inflammatory signals but also in the maintenance of vascular integrity. Especially prostacyclin ( PGI(2)), which exerts vasodilatory and antiplatelet properties, is formed to a significant extent by COX- 2, and its levels are reduced to less than half of normal when COX- 2 is inhibited. This review outlines the rationale for the development of selective COX- 2 inhibitors and the pathophysiological consequences of selective inhibition of COX- 2 with special regard to vasoactive prostaglandins. It describes coxibs that are currently available, evaluates the current knowledge on the risk of atherothrombotic events associated with their intake and critically discusses the consequences that should be drawn from these insights. Copyright (C) 2005 S. Karger AG, Basel
Samuel S. Cox portrait
No full textPortrait of Samuel S. Cox, ca. 1890-1899. Cox strongly opposed slavery's expansion into new territory during the 1850s. As an Ohioan, he served in the United States House of Representatives from 1857 to 1865. Cox also served New York as a U.S. representative from 1869 to 1885 and from 1887 to 1889. He died in office in 1889. This cabinet card may have been created after his death as a memorial
Mary Ann Cox Index: Royal Society Collection
No full textBurton-Wood: in a series of letters, by a lady (Mrs. - Cox nee Wight), London (printed for the author by H.D.Steel) 1783, vol.11
(octovo vol, leather bound)
Enclosed: note The book Burtonwood was written by the mother of
Mary Ann Cox who ran the first coach from Hobart to Launceston.
It was passed on to me by her grand-daughter Miss Dora Clerk of Malahide.
I also am a grand-daughter of Mrs. Cox. Joan Harvey
(John Edward Cox m. Mary Ann Halls
V.D.L. 1821 J.E.C. started Hobart-Launceston coach) - (note - Mrs.
Harvey's identification of the author of the volume was based on family
tradition although not confirmed - no details are known of John Edward
Cox's parents)
Poems by C(harles) Best c 1847 - 1849
Includes poems to Miss Wilmot (Georgiana Wilmot, - Mrs. C. Butler)
and Mary Wilmot.
Enclosed: note by Joan Harvey
Article on Mrs. Mary Ann Cox 1950.
A pioneer career woman (on coach service between Hobart - Launceston)
from "Woman's Day" Aug. 21, 1950 (news clipping)
R.S. 14
Leukocyte infiltration in COX-2<sup>−M/−M</sup> and COX-2<sup>+/+</sup> mice.
No full text<p>MPO enzymatic activity (panel A) was statistically similar in COX-2<sup>−M/−M</sup> and COX-2<sup>+/+</sup> livers at 6 h and 24 h post-IRI. Ly-6G<sup>+</sup> neutrophil (panel B) and granulocyte (panel C) infiltration were also comparable in COX-2<sup>−M/−M</sup> and COX-2<sup>+/+</sup> livers after IRI. Mac-1<sup>+</sup> (panel D) and CD68 (panel E) infiltrating macrophages were significantly reduced in COX-2<sup>−M/−M</sup> livers at 24 h post-reperfusion, but were statistically indistinguishable in COX-2<sup>−M/−M</sup> and COX-2<sup>+/+</sup> livers at 6 h after IRI. No statistical differences in MMP-9 expression (panel F) could be demonstrated in livers of COX-2<sup>−M/−M</sup> and COX-2<sup>+/+</sup> mice post-IRI. Representative immunostaining (panel G) of infiltrating Ly-6G<sup>+</sup> (a,b,e,f) and Mac-1<sup>+</sup> (c,d,g,h) leukocytes in livers of COX-2<sup>+/+</sup> (a,c,e,g) and COX-2<sup>−M/−M</sup> (b,d,f,h) mice at 6 h (a to d) and 24 h (e to h) post IRI; (n = 5–6/group; * indicates p<0.05).</p
Histology and serum transaminase levels in COX-2<sup>−M/−M</sup> and COX-2<sup>+/+</sup> mice.
No full text<p>H&E staining of liver sections (panel A) from COX-2<sup>+/+</sup> mice (a, c, e) and COX-2<sup>-M/-M</sup> mice (b, d, f) revealed good histological preservation in naïve livers (a, b) and comparable extensive hepatic necrosis, vascular congestion, and disruption of liver architecture in COX-2<sup>+/+</sup> livers (c, e) and COX-2<sup>−M/−M</sup> livers (d, f) at 6h (c, d), and 24h (e, f) after IRI. Serum AST and ALT levels (panel B) were also similar in COX-2<sup>+/+</sup> mice (black bars) and COX-2<sup>−M/−M</sup> mice (white bars) after IRI; (n = 5-6/group).</p
Celecoxib inhibition of hepatic IRI for both COX-2<sup>−M/−M</sup> mice and COX-2<sup>+/+</sup> mice.
No full text<p>Liver H&E staining (panel A) demonstrated that administration of celecoxib, a selective COX-2 inhibitor, markedly reduced hepatocellular necrosis and vascular congestion in both COX-2<sup>+/+</sup> mice (c) and COX-2<sup>−M/−M</sup> mice (d), when compared with respective vehicle treated COX-2<sup>+/+</sup> mice (a) and COX-2<sup>−M/−M</sup> mice (b) controls 6 h post IRI. Celecoxib therapy significantly reduced the serum AST (panel B) and ALT (panel C) levels in both COX-2<sup>+/+</sup> mice (dark grey bars) and COX-2<sup>−M/−M</sup> mice (light grey bars), when compared to respective vehicle treated control COX-2<sup>+/+</sup> mice (black bars) and COX-2<sup>−M/−M</sup> mice (white bars) after 6 h of hepatic IRI (n = 5/group; * indicates p<0.05).</p
Concentration in Knowledge Output: A case of Economics Journals
No full textThis paper assesses the degree of author concentration in seven economics journals, which were published in India during 1990-2002. To measure the degree of author concentration, Lotka's Law was used. Moreover, we also make an exploratory analysis of the geographic, economics subfield and institutional concentration in 704 economics journals. An important finding of this paper is that specialized journals in the sample report the highest degree of author concentration. This result is quite similar to the findings by Cox and Chung (1991). Furthermore, there are several instances showing that the journals lean towards certain norms; this may affect the flow of innovative ideas into economics. We conclude that a knowledge activity, involving the high degree of concentration and a biased publication process, may affect the flow of new ideas into the discipline.Concentration, Lotka's Law
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Folder 3: Model engine data sheets and operating instructions, C - D, 1946, 1950, 1960
No full textOwner's manual for the Cox Sandblaster .049 engine powered car. Document from The Wesley Pettinger Engine Model Collection
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