1,721,015 research outputs found
Responsabilità sociale e strategia d'impresa
No full textPartendo dal modello della formula imprenditoriale sviluppato da Coda nel 1984, il capitolo presenta alcune proposizioni volte a collegare le strategie competitive e di crescita, da una parte, con le relazioni con gli stakeholder, dall'altra. In particolare, seguendo una logica di tipo comparativo, si riflette sull'impatto che le scelte della strategia competitiva di base e del tipo di crescita (interna o esterna) hanno sulla coesione sociale, nonchè sull'impatto che il livello di coesione sociale ha sulla fattibilità e sulle possibilità di successo delle strategie competitive di base e delle strategie di crescita
Differential expression of circular RNAs in a mouse model of autism spectrum disorders
Full text linkAutism spectrum disorder (ASD) comprises a heterogeneous group of pervasive developmental disabilities characterized by compromised social interactions and communication skills, and by restrictive and repetitive behaviors. Emerging evidence suggests the involvement of non-coding RNAs (ncRNAs) in the pathophysiology of ASD. circRNAs arisen in the last decades as a novel class of ncRNAs and recent reports have shown their implication in the pathogenesis of several human neurological diseases. circRNAs are endogenous stable molecules, characterized by a covalently closed structure resulting from a backpslicing reaction. They are evolutionary conserved, abundant and significantly enriched in the brain. Although the biological function is still unknown, specific circRNAs are regulated by neuronal activity and have been implicated in plasticity mechanisms.
In this study, we present the expression profile of circRNAs in the hippocampus of BTBR T + tf/J (BTBR) mouse model for Autism Spectrum Disorder (ASD), compared to age-matched C57BL/6J (B6) mice. We identified several circRNAs whose expression is consistently altered, and 12 circRNAs and their corresponding linear counterparts were validated by RT-qPCR analysis. The ASD-related circCdh9 and circRmst have been further characterized in terms of molecular structure and expression. To evaluate their functional role in a physiological context, we characterized their expression during mouse development, neuronal differentiation and homeostatic plasticity. Interestingly, our results suggest a possible involvement of circCdh9 and circRmst in brain development and neuronal differentiation. Moreover, to comprehensively investigate the transcriptomic profile of the hippocampus of BTBR mice, we analyzed the gene and miRNA expression patterns. We performed enrichment analysis of BTBR differentially expressed RNA species and found interesting biological and molecular pathways associated to ASD phenotype. Lastly, we compared the circRNAs and gene expression profiles and we identified 6 genes highly modulated as circular and linear isoforms, indicative of a low correlation in the expression of circRNAs and their host genes.
In conclusion, our study has identified and analyzed differentially expressed circRNAs in the BTBR hippocampus, and we deepen characterized two ASD-associated circRNAs candidates. By integrating the circRNAs and gene expression profiles, we found a coregulation in the expression of specific genes ASD related. Moreover, we explored for the first time the miRNA expression profile in the hippocampus of BTBR mice, and we found 18 significantly modulated miRNAs. Functional studies are in progress to shed more light on the physiological function of circCdh9 and circRmst and their putative role in the pathophysiology of ASD
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Small worlds evolving: governance reforms, privatizations and ownership networks in Italy
No full textHow do ownership networks among business enterprises evolve over time? What roles do corporate governance reforms and privatization programs play in shaping the structural characteristics of these networks? This article addresses these questions by leveraging on small-world analysis techniques applied to the ownership networks among Italian enterprises in 1990 and 2000. Italy underwent a significant program of privatizations over the decade under study, coupled with changes in the corporate law aimed at strengthening the defense of minority shareholders. The data show signs of significant fragmentation of the overall network, but at the same time of stability in the structure of its main component, as measured by small-world coefficients. Further, the role of the key players in the network seems to remain relatively stable despite the major turbulence at the institutional level as well as in the structural characteristics of the complete network
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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