803 research outputs found

    Effects of long-term use of clonazepam on nonrapid eye movement sleep patterns in rapid eye movement sleep behavior disorder

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    When this paper was originally published the affiliation for Giuseppe Plazzi was incorrect. See doi: 10.1016/j.sleep.2013.10.001 for the correct one.Abstract not availableRaffaele Ferri, Marco Zucconi, Sara Marelli, Giuseppe Plazzi, Carlos H. Schenck, Luigi Ferini-Stramb

    Video polysomnography and dentofacial features in a case of sleep-disordered breathing and bruxism

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    Aims Obstructive sleep apnea (OSA) is the most common condition among a group of disorders, called sleep-disordered breathing, that can affect both adults and children. It is characterized by repeated episodes of airway obstruction for more than 10 seconds during sleep, resulting in pauses in breathing. OSA is associated with significant metabolic, cardiovascular, and neurocognitive sequelae in children. Children with OSA have increased upper airway resistance during sleep due to a combination of soft tissue hypertrophy, craniofacial dysmorphology, and/or obesity. Sleep bruxism (SB) is a sleep-movement disorder. It is characterized by rhythmic masticatory muscle activity (RMMA), which consists of recurrent episodes of phasic or tonic jaw muscle contractions during sleep with or without tooth grinding. The gold standard for diagnosis of OSA and SB is overnight polysomnographic testing. Case report MB is a 10-year-old boy with loud snoring, pauses in breathing while asleep, agitated sleep with frequent awakenings, bizarre sleeping positions, bruxism, and poor academic performance in whom pharmacotherapy is being considered. Past medical history includes adenotonsillectomy and seasonal respiratory infections. BMI 18,1 (healthy weight). A parent school-aged children questionnaire is filled in. The orthodontic examination shows a narrow skeletal upper jaw, mandibular retrognathism and tooth wear. The patient underwent comprehensive polysomnography with video/audio recording. Results Sleep macrostructure was characterized by sleep fragmentation with high number of awakenings/arousals and prolonged REM latency. Some arousals were associated with RMMA, withoud tooth grinding but with oro-buccal activity semiologically similar to bruxism. Microstructure of sleep was instable, with increase in CAP rate. The apnea hypopnea index (AHI) was 5,7/h per hour (normal < 1.0 per hour in children), min SaO2 96,7%. The patient was treated with rapid maxillary expansion followed by a jaw advancement device. Conclusions When there is residual OSA after T & A is performed, other factors should be evaluated to decide the next course of action. For children with a high arched palate, rapid maxillary expansion has been shown to improve AHI. To manage sleep disorders optimally in school-aged children and to improve quality of sleep and academic performance, it is to be hoped that dentists and sleep specialist cooperate

    c-fos spontaneous expression during wakefulness is reversed during sleep in neuronal subsets of the rat cortex

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    c-fos is a transcriptional regulatory factor that can be rapidly and transiently induced in brain cells in response to a variety of stimuli. However, we observed that c-fos mRNA, in absence of exogenous stimulation, oscillates in different regions of the rat brain in relation to the rest-activity and sleep-wake circadian cycle (Grassi-Zucconi et al, 1993).This previous study was based on Northern blot analysis and did not provide any information on the neuronal cell populations subserving the circadian c-fos oscillation. Therefore, we used immuno- cytochemistry to detect in the rat brain the cells that express the Fos nuclear protein, encoded by the c-fos gene, during spontaneous wakefulness and sleep.The present report derives from analysis of the cerebral cortex; the findings observed at subcortical levels will be described elsewhere

    International Commercial Courts: An Introductory Overview

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    On July 14th, 2022, the Universities of Bologna, Milan, and Verona jointly organized a webinar on the topic: “International commercial courts: a paradigm for the future of adjudication?”. The interest aroused by the individual speeches, the numerous ideas that emerged from the debate between the speakers, and the rich exchange of opinions among the participants suggested deepening the analysis of such a topical subject matter in a collective volume, to which further eminent specialists in the field of international litigation and arbitration contributed. The editors are thus honored to present this volume, which they hope will assist academics and practitioners in navigating the diverse and dynamic world of international commercial courts, with a view to triggering further analysis and insights

    A lexicon for Italian cinema: A conversation about history, theory and critique

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    This article represents the outcome of a round table organized and conducted by Giacomo Tagliani about the Lessico del cinema Italiano/Lexicon of Italian Cinema (2014–2016). This research and editorial project comprises three volumes and 21 entries that address the history of Italian cinema through an original and challenging approach, namely to detect a list of conceptual clusters able to provide new perspectives over the heritage of Italian films. In this refined version, the authors who took part in that round table, that is, Roberto De Gaetano (also editor of the volumes), Massimiliano Coviello, Luca Venzi and Francesco Zucconi, outline their involvement in the research project, their specific methodological references, their peculiar vision of the history of Italian cinema and eventually their point of view onto its current situation. This written conversation offers a broad survey of Lessico’s key aspects and addresses important methodological, theoretical and critical issues, trying to establish an interdisciplinary dialogue among different fields of studies

    Commento agli artt. 838 bis–838 quinquies

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    Commento agli artt. 838 bis–838 quinquies alla luce della riform
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